I'm a veterinary pathologist, working at the university of Teramo as Assistant Professor. I graduated with a Doctor of Veterinary Medicine from the University of Teramo (Italy) in 2003. After completing a residency program at the School of Veterinary Medicine of Bern (Switzerlands), I became a Diplomate of the European College of Veterinary Pathologists (ECVP) in 2011. Before joining Utrecht University, where I worked form January 2017 to January 2021, I was Assistant professor in Veterinary Pathology and teacher of Cellular Pathophysiology at the University of Teramo (Italy), from 2005 to 2016.

My main research interests are veterinary and comparative oncology and dermatopathology. My research is now focused on finding new therapeutic approaches and biomarkers based on extracellular vesicles for canine tumours and on the study of spontaneous canine melanoma as a model for the study of human melanoma.

I also have a strong interest on the pathology of laboratory animals and pathological analysis of animal models, with expertise on liver pathology (cancer, nonalcoholic fatty liver disease) and age-related lesions, gained working at the Dutch Molecular Pathology Center, Utrecht University.

Dr. Laura Bongiovanni, DVM, PhD, Dipl.ECVP

Veterinary Pathologist

 

Main fileds of interest: Veterinary and comparative oncology, extracellular vesicles, pathology of laboratory animals, dermatopathology, pathology of wild and exotic animals, molecular biology, histopathology.

Publications: 53 papers on international journals with referees, most of them concerning oncology, dermato-histopathology, experimental pathology and pathology of exotic animals, 4 book chapters, 12 meeting abstracts published on normal or special issues of referred journals indexed on ISI Web of Knowledge; 48 abstracts (in proceedings of Italian and international conferences with referees), oral communications, posters.

Language: Italian (mother tongue), English, French, basic Dutch.

 

Education

2016-2020: PhD Program Veterinary Health and Experimental Sciences, University of Perugia, Perugia, Italy. Tutor: Dr. Chiara Brachelente, University of Perugia (IT); Supervisor: Prof Alain de Bruin, Utrecht University (NL).

2007-2010: Residency Program for the European College of Veterinary Pathologists (ECVP) at the Institute of Veterinary Pathology of the University of Bern (CH), supervisors Prof Maja Suter and Dr Horst Posthaus, obtaining the ECVP qualification on February 2011.

2003-2006: Postgraduate Degree Specialization School "Animal health, breeding and zootechnical productions", Teramo University, with a thesis on "Papillomavirus and neoplastic skin diseases".

2003: Degree in Veterinary Medicine (110/110 cum laude) with experimental research thesis on "Evaluation of Apoptosis in Canine Intracutaneous Cornifying Epitheliomas and Squamous Cell Carcinomas"

1998: Secondary School certificate at the State Secondary School "M. Curie" (Giulianova, Italy) with marks 60/60.

Licence to practice and professional specialities

2020: PhD in "Veterinary Health and Experimental Sciences"

2011: Diplomate of the European College of Veterinary Pathologists

2006: Postgraduate Degree Specialization School "Animal health, breeding and zootechnical productions"

2003: Licence to practice (Italian state exam)

 

Professional activities

Jan 2021-present: Assistant Professor in Veterinary Pathology University of Teramo, Faculty of Veterinary Medicine, Teramo (Italy).

2019-2021: Researcher, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen (The Netherlands).

Jan 2017-Jan 2021: Assistant Professor/Researcher in Veterinary Pathology, Department of Biomolecular Health Sciences, Dutch Molecular Pathology Center (DMPC), Utrecht University, Utrecht (the Netherlands). Professional activity: research, DMPC service.

2005- Jan 2017: Assistant Professor/University Researcher in Veterinary Pathology, Faculty of Veterinary Medicine, Teramo University, Teramo (Italy). Professional activity: research, diagnostic service, teaching.

2004: Postgraduate fellowship, University of Teramo, research on "Evaluation of apoptosis in intracutaneous cornifying epitheliomas and cutaneous squamous cell carcinoma of dog. Correlation with Heat Shock Protein expression in the same tumours". Tutor Prof. Leonardo Della Salda.

2001-2002: Part-time student activity (150 hours) at the Veterinari Pathology Unit, Faculty of Veterinari Pathology, University of Teramo (Italy)

Offices Held

2014-present: member of the Oncology-Pathology Working group - Canine Melanoma Subgroup; co-authors of the OPWG melanoma consensus (http://vetcancersociety.org/wp-content/uploads/2020/11/Melanoma-Consensus-Final_10AUG2020.pdf), and of the Veterinary Cancer guidelines and protocols on cutaneous and oral melanoma (https://www.vcgp.org/).

2017-2021: veterinary pathologist at the DMPC, Dutch Moelcular Pathology Center, Utrecht University, Utrecht (The Netherlands)

2014-2017: Vice-president ISVD (International Society of Veterinary Dermatopathology)

2016: Scientific Program Chair of the ISVD Meeting and sessions at the 8th WCVD, May 31 – June 4 2016, Bordeaux, France.

2014: Organization of the ISVD Workshop "Mystery Cases in Veterinary Dermatopathology" at the ESVP/ECVP/ESTP Annual Meeting, 27^th-30^th August, Berlin, Germany

2010-2014: Board member at large of the ISVD (International Society of Veterinary Dermatopathology)

2013: May 29-31: Organization officies X National Meeting of the Italian Society of Veterinary Pathologists (AIPVet), Giulianova, Teramo, Italy

2005/2006: Tutor of the Postgraduate Master on "Veterinary Dermatology", University of Teramo.

2005: May 10-12 and June 9-11 2005: Organization officies of the Course "Veterinary Cytopathology", University of Teramo, Teramo, Italy

 

 Research interests

- Veterinary and comparative oncology: Canine Melanoma; Skin cancers; Role of Extracellular Vesicles in cancer in diseases; Mechanisms of cancer progression: the epithelial to mesenchymal transition; the contribution of stem cells in tumour development and progression; deregulation of cell cycle in cancer cells; Role of apoptosis and anti-apoptotic molecules in carcinogenesis.

- Veterinary and comparative dermatopathology.

- Experimenthal pathology, Pathology of Laboratory animals: age-related lesions; liver pathology.

- Pathology of exotic, wild and zoo animals.

 Specific skills

Histopathology; Immunohistochemistry; Immunofluorescence;  extracellular vesicles isolation techniques; biomolecular techniques (RNA analysis); basic knowlwdge on cell culture; Necropsy techniques (small, large, laboratory and exotic animals); Cytologic techniques.

 

 Teaching experience

 Undergraduate students

2012-2017: Cellular Pathophysiology, Biotechnology First Degree Course, University of Teramo (80h)

2012-2016: Dermatopathology, Faculty of Veterinary Medicine, University of Teramo (8h)

2012-2015: Descriptive Pathology, Faculty of Veterinary Medicine, University of Teramo (5h)

2005-2012: Production of monoclonal antibodies, Biotechnology First Degree Course, University of Teramo (30h)

2004-2017: Assistant in teaching of Veterinary Pathology on gross pathology and necropsy techniques; thesis assistant in a research setting; member of Veterinary Pathology exam commission, Faculty of Veterinary Medicine, University of Teramo

 Postgraduate students

2017-2018: Workshops on mouse necropsy technique, DMPC, Utrecht University, Groningen University (NL).  

2007: Histopathological patterns of cutaneous vasculitis, Postgraduate Master on Veterinary Dermatology, University of Teramo (IT).

2005-2006: Skin Cytology, Postgraduate Master on Veterinary Dermatology, University of Teramo (IT).

 

 Coordination of students in research projects

2018-2020: Daily supervisors Master student. Utrecht University (NL). 

2020-2021: Daily Supervisor HP (Honours Program) veterinary student: reserach on Novel biomarker in canine and feline cancer research Utrecht University (NL).

2017-2018: Daily Supervisor HP (Honours Program) veterinary student: reserach on New biomarkers in canine melanoma: role of cell cycle gene transcripts contained in blood extracellular vesicles as cancer biomarkers. Utrecht University (NL).

2011-2015: Teacher-Tutor of PhD student: PhD "Epidemiology and advanced diagnostic in comparative pathology", research thesis "Progression, invasion and metastasis in human and canine cutaneous tumours: morphological and pathogenetic study for the identification of the molecular pathways implicated as potential therapeutic targets".

Undergraduated students: 

From 2017-present: supervisor of students of Veterinary Medicine and Biomedical Sciences, Utrecht University for research theses.

From 2009 to 2017: supervisor of students of Biotechnology and Veterinary Medicine courses for research theses, University of Teramo (IT). 

 

 Memberships

From 2018: NLSEV (Netherlands Society of Extracellular Vesicles)

From 2014: OPWG (Oncology-Pathology Working Group)

From 2011: ECVP (European College Veterinary Pathologists)

From 2007: ISVD (International Society of Veterinary Dermatopathology)

From 2004: ESVP (European Society of Veterinary Pathology)

From 2004: AIPVet (Italian Society Veterinary Pathologists)

From 2005-2015: ESVD (European Society of Veterinary Dermatology)

 

Awards

2015: Woman Award City of Teramo 2015 - Research (Premio Donna città di Teramo per la ricerca 2015), European women - housewives federation. Teramo, 30th May 2015.

2013: George Fleming Prize 2013 The Veterinary Journal: L Maniscalco, S Iussich, E Morello, M Martano, P Buracco, B Biolatti, F Riondato, L Della Salda, M Romanucci, D Malatesta, F Tirrito, L Bongiovanni, R De Maria. PDGFs/PDGFRs in canine osteosarcoma: new targets for innovative therapeutic strategies in comparative oncology. The Veterinary Journal. 2013 Jan;195(1):41-7.

2012: Selected as a Supporting Original Study 7^th World Congress of Veterinary Dermatology, Vancouver, Canada, July 25 - 28, 2012:

• Bongiovanni L., D'Andrea A., Romanucci M., Malatesta D., Candolini M., Della Salda L., Mechelli L., Sforna M., Brachelente C. Epithelial to mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours..

2012: Selected as a Supporting Original Study 7^th World Congress of Veterinary Dermatology, Vancouver, Canada, July 25 - 28, 2012:

• C. Brachelente, I. Porcellato, M. Sforna, E. Lepri, L. Mechelli, L. Bongiovanni. Contribution of stem cells to epidermal and hair follicle tumors in the dog.

2011: Best poster Award "R. PREZIOSI" 2011 at the 8^th National Meeting of the Italian Society of Veterinary Pathology (AIPVet) 2011, Padova (Italy), 15-17 Giugno 2011: 

• Bongiovanni L, Romanucci Mariarita, Liberatori Silvia, Oevermann Anna, Della salda Leonardo. Beta-catenin and Survivin expression in canine peripheral nerve sheath tumours.

2008: Selected as a Supporting Original Study, 6^th World Congress of Veterinary Dermatology, Hong Kong, 19-22 November 2008:

• Bongiovanni L., Colombi I., Fortunato C., Della Salda L. Survivin expression in normal canine epidermis and in human and canine cutaneous squamous cell carcinomas.

 

Funded Research Projects

2017-2021: participation as specialized, ECVP board certified,veterinary pathologist: PAT LS PB DMPC, Utrecht University, Utrecht (NL). Ref. n. DE. 120116.2.1.

2017-2021: participation as researcher: PAT LS BP Onderzoek TR, Utrecht University, Utrecht (NL). Ref. n. DE 120115.2.1. 

2017-2018: Co-applicant: "Application of the 3D cell culture techniques to the study of canine melanoma as a comparative model for human melanoma” Fondazione Cassa di Risparmio di Perugia (Perugia, Italy).

2010- 2017: Perticipation in the project RECAL “RECupero e Analisi post-mortem di esemplari di Lontra (Lutra lutra)” (Recovery and post-mortem analysis of otters (Lutra lutra), together with Lutria, Wildlife research and consulting, National Parc of Cilento, Vallo di Diano and Alburni, Servizio Sanità Animale (ASL).

2014: Principal investigator, together with Prof Monika Welle (University of Bern): "Identification of stem cell markers in canine hair follicle tumours". Swiss National Science Foundation - International Short Visit Program -University of Bern, Institute of Veterinary Pathology (Bern, Switzerland). "

2013-2014: As one of the principal investigators: "Analysis of the molecular pathways involved in metastatization of canine melanoma and its applicability in the study of human melanoma". Fondazione Cassa di Risparmio di Perugia (Perugia, Italy). 

2009: Co-applicant: "Evaluation of the expression of the Hsp72 and some stress indicators in captive marine mammals serum". University of Teramo Scientific Project 2009.

2008: Co-applicant: "Evaluation of the expression of heat shock proteins (HSPs) and correlation with Hsp-clinet proteins as molecular target in canine osteosarcoma therapy". National Program of Scientific Research PRIN.

2006: Co-applicant: "Study of the oncogenetic mechanisms of papillomavirus in cutaneous and ocular neoplasms of goat" as part of the National Project: "Viral Oncogenesis in small and large ruminants: role of papillomavirus and considerations on food safety". National Program of Scientific Research PRIN.

2006: Co-applicant: "Evaluation and identification of marker of tumour progression in mammary carcinoma of dog". University of Teramo Scientific Project 2006.

2005: Co-applicant: Study of female gamete nuclear functions of prepubertal lamb. University of Teramo Scientific Project 2005.

 

Advanced Courses attended

2017: Pathology of Laboratory animals in Biomedical Research. Module 1: Pathology of the Mouse and Rat. Fondazione G. Bernardini. 1-3 May 2017, Leiden University Medical Center, Leiden (the Netherlands).

2009: AFIP descriptive course, Barcelona (Spain) May 18-22 2009

2008: ECVP/ESVP Summer School in Veterinary Pathology, Jaca (Spain) July 13-25 2008

2007: ECVP/ESVP Summer School in Veterinary Pathology, Helsinki (Finland) July 23-August 2 2007

2007: ESVD-ECVD Workshop on Skin Oncology, Bern (Switzerland) July 5-7 2007

2006: ESVD-ECVD Workshop on Dermatology and Endocrinology, Spa (Belgium) June 8-10 2006

2005: "Veterinary Cytopathology" University of Teramo, Teramo (Italy) May 10-12 and June 9-11 2005

2003: Postgraduate Professional Training Course "Operators in the investigation of domestic and wild animals predation cases", Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale", Teramo. September-November 2003

 

International Meeting attended

2019: Third annual meeting of the Netherlands Society for Extracellular Vesicles (NLSEV), November 8th 2019, Utrecht, De Zalen van Zeven, NL.

2019: JOINT CONGRESS OF VETERINARY PATHOLOGY AND VETERINARY CLINICAL PATHOLOGY on 25-28 September 2019 at Burgers’ Zoo Arnhem, the Netherlands.

2018: Second annual meeting of the Netherlands Society for Extracellular Vesicles (NLSEV), Nov 9th 2018, Amsterdam UMC, NL.

2018: BSAVA Congress, 5-8 April, Birmingam, UK. Invited speaker, oral presentations.

2016: WCVD, Bordeaux (FR), 31 May- 4 June, 2016. Oral presentation. ISVD Annual Meeting.

2014: II Joint European Congress of the ESVP, ECVP, ESTP- Berlin, 27th - 30th August 2014.

Invited Speaker; oral presentation; organizer of the session "Mystery cases in Veterinary Dermatopathology".

2013: ISVD Annual Meeting at the 31^st ESVP/ECVP Annual Meeting, September 4-7 2013, London (UK). Oral presentation

2012: 7^th World Congress of Veterinary Dermatology, Vancouver (Canada) July 24-28, 2012. Oral presentation of a Supporting Original Study and chairperson

2011: 29^th Meeting of the European Society of Veterinary Pathology (ESVP), Uppsala (Sweden). September 7-10 2011. Oral presentation

2010: ISVD Annual Meeting, Pre-Congress Day Session at the American Veterinary Dermatology Forum, Portland (Oregon, USA). April 14 2010.

2010: 24^th Meeting of European Society of Veterinary Dermatology (ESVD) and European College of Veterinary Dermatologists (ECVD), Firenze (Italy). September 23-25 2010.

2009: 27^th Meeting of the European Society of Veterinary Pathology (ESVP), Krakow (Poland). September 9-13 2009. Poster presentation.

2008: Precongress Day International Society of Veterinary Dermatopathology (ISVD), Hong Kong November 19 2008.

2008: 6^th World Congress of Veterinary Dermatology, Hong Kong November 19-22 2008. Oral presentation of a Supporting Original Study and chairperson

2007: 25^th Meeting of the European Society of Veterinary Pathology (ESVP), Munich (Germany) August 29- September 1 2007. Oral presentation

2006: 21^st Meeting European Society of Veterinary Dermatology (ESVD), Lisbon (Portugal) September 7-9 2006. Poster presentation

2006: Precongress Day International Society of Veterinary Dermatopathology (ISVD), Lisbon (Portugal) September 6 2006.

2005: 23^rd Meeting of the European Society of Veterinary Pathology (ESVP), Naples (Italy), September 7-10 2005. Oral presentation

 

 Invited speaker

JOINT CONGRESS OF VETERINARY PATHOLOGY AND VETERINARY CLINICAL PATHOLOGY 2019: Liquid biopsies; The Potential Role of EVs as Biomarkers in Veterinary Medicine. 25-28 September 2019, Burgers’ Zoo Arnhem, the Netherlands.

BSAVA Congress 2018: Controversies in the histopathological diagnosis of skin disease (together with Dr Tim Nuttall), What your pathologist is trying to tell you and questions you should ask them, How to do a post mortem examination in general practice and get diagnostic results, 5-8 April 2018, Birmingam, UK.

Research Seminar, Canine Melanoma as a model for the study of human melanoma. University of Perugia, 18th June 2015, Perugia (Italy)

Comparative Pathology Joint Seminar University of Bern (Switzerland), 20-01-2015, together with Dr Yara Banz (Pathology Unit, University of Bern): Naturally occurring melanoma in dogs as a model for human melanoma.

II Joint European Congress of the ESVP, ECVP, ESTP- Berlin, 27th - 30th August 2014: The International Society of Veterinary Dermatopathology: objective, goals and future prospects.

 

Invited reviewer for the scientific journals

Journal Current Medicinal Chemistry; Research in Veterinary Science; Molecular Medicine; British Journal of Dermatology; Technology in Cancer Research and Treatment; Asian Pacific Journal of Tropical Biomedicine; British Journal of Cancer; Veterinary and Comparative Oncology; Journal of Veterinary Medicine: Research and Reports; Disease Markers; Veterinary Pathology; Journal of Veterinary Diagnostic Investigation; International Journal of Molecular Sciences; JAVMA; Veterinarski arhiv.

Executive member of Editorial Board 

Journal of Coastal Life Medicine.

Guest Editor - Frontiers in Veterinary Science

Research Topic "Canine Melanoma in comparative oncology: translate research advances to develp new diagnostic and therapeutic options". Editor team: Chiara Brachelente, Philip Bergman, Steven Dow. 

https://www.frontiersin.org/research-topics/16379/canine-melanoma-in-comparative-oncology-translate-research-advances-to-develop-new-diagnostic-and-th

 

Invited review for Scientific Project Proposals:

2012-2015: ISVD (Interanational Society Veterinary Dermatopathology)

2015: ISF (Israel Science Foundation)

2013: SIDEV(Italian Society of Veterinary Dermatology)

 

 

Articles - 2020

Bongiovanni, Laura, Brachelente, Chiara, Moreno, Eva & Welle, Monika M. (01.06.2020). Canine epithelial skin tumours - Expression of the stem cell markers Lgr5, Lgr6 and Sox9 in light of new cancer stem cell theories. Veterinary Sciences, 7 (2) (15 p.).

Moreno, Eva, Toussaint, Mathilda J M, van Essen, Saskia C, Bongiovanni, Laura, van Liere, Elsbeth A, Koster, Mirjam H, Yuan, Ruixue, van Deursen, Jan, Westendorp, Bart & de Bruin, Alain (2020). E2F7 is a potent inhibitor of liver tumor growth in adult mice. Hepatology This article is protected by copyright. All rights reserved..

Sladky, Valentina C, Knapp, Katja, Soratroi, Claudia, Heppke, Julia, Eichin, Felix, Rocamora-Reverte, Lourdes, Szabo, Tamas G, Bongiovanni, Laura, Westendorp, Bart, Moreno, Eva, van Liere, Elsbeth A, Bakker, Bjorn, Spierings, Diana C J, Wardenaar, René, Pereyra, David, Starlinger, Patrick, Schultze, Simon, Trauner, Michael, Stojakovic, Tatjana, Scharnagl, Hubert, Fava, Luca L, Foijer, Floris, de Bruin, Alain & Villunger, Andreas (13.01.2020). E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Developmental Cell Copyright © 2019 Elsevier Inc. All rights reserved..

Sladky, Valentina C., Knapp, Katja, Soratroi, Claudia, Heppke, Julia, Eichin, Felix, Rocamora-Reverte, Lourdes, Szabo, Tamas G., Bongiovanni, Laura, Westendorp, Bart, Moreno, Eva, van Liere, Elsbeth A., Bakker, Bjorn, Spierings, Diana C.J., Wardenaar, René, Pereyra, David, Starlinger, Patrick, Schultze, Simon, Trauner, Michael, Stojakovic, Tatjana, Scharnagl, Hubert, Fava, Luca L., Foijer, Floris, de Bruin, Alain & Villunger, Andreas (10.02.2020). E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Developmental Cell, 52 (3), (pp. 335-349.e7) (22 p.).

Silvestri, Serenella, Porcellato, Ilaria, Mechelli, Luca, Menchetti, Laura, Iussich, Selina, De Maria, Raffaella, Sforna, Monica, Bongiovanni, Laura & Brachelente, Chiara (01.09.2020). E-Cadherin Expression in Canine Melanocytic Tumors - Histological, Immunohistochemical, and Survival Analysis. Veterinary Pathology, 57 (5), (pp. 608-619) (12 p.).

Verboom, Lien, Martens, Arne, Priem, Dario, Hoste, Esther, Sze, Mozes, Vikkula, Hanna, Van Hove, Lisette, Voet, Sofie, Roels, Jana, Maelfait, Jonathan, Bongiovanni, Laura, de Bruin, Alain, Scott, Charlotte L, Saeys, Yvan, Pasparakis, Manolis, Bertrand, Mathieu J M & van Loo, Geert (18.02.2020). OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Reports, 30 (7), (pp. 2237–2247.e1–e6) (17 p.). Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved..

Sladky, Valentina C., Knapp, Katja, Szabo, Tamas G., Braun, Vincent Z., Bongiovanni, Laura, van den Bos, Hilda, Spierings, Diana C.J., Westendorp, Bart, Curinha, Ana, Stojakovic, Tatjana, Scharnagl, Hubert, Timelthaler, Gerald, Tsuchia, Kaoru, Pinter, Matthias, Semmler, Georg, Foijer, Floris, de Bruin, Alain, Reiberger, Thomas, Rohr-Udilova, Nataliya & Villunger, Andreas (01.01.2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports

Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy & Kuball, Jürgen (05.02.2020). TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. Journal of Leukocyte Biology (11 p.). ©2020 Society for Leukocyte Biology..

van de Peppel, Ivo P, Rao, Anuradha, Dommerholt, Marleen B, Bongiovanni, Laura, Thomas, Rachel, de Bruin, Alain, Karpen, Saul J, Dawson, Paul A, Verkade, Henkjan J & Jonker, Johan W (2020). The Beneficial Effects of Apical Sodium-Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition. Molecular Nutrition and Food Research, 64 (24) (12 p.). This article is protected by copyright. All rights reserved..

Articles - 2019

Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Håkan, Bongiovanni, Laura, de Bruin, Alain, Sebestyen, Zsolt & Kuball, Jürgen (2019). Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells. Journal for ImmunoTherapy of Cancer, 7 (1), (pp. 69).

Kierkels, G J J, Scheper, W, Meringa, A D, Johanna, I, Beringer, D X, Janssen, A, Schiffler, M, Aarts-Riemens, T, Kramer, L, Straetemans, T, Heijhuurs, S, Leusen, J H W, San José, E, Fuchs, K, Griffioen, M, Falkenburg, J H, Bongiovanni, L, de Bruin, A, Vargas-Diaz, D, Altelaar, M, Heck, A J R, Shultz, L D, Ishikawa, F, Nishimura, M I, Sebestyén, Z & Kuball, J (2019). Identification of a tumor-specific allo-HLA-restricted γδTCR. Blood advances, 3 (19), (pp. 2870-2882) (13 p.). © 2019 by The American Society of Hematology..

van der Schoor, Lori W E, Hulzebos, Christian V, van Faassen, Martijn H, Kema, Ido, de Bruin, Alain, Havinga, Rick, Koster, Mirjam, Youssef, Sameh A, Bongiovanni, Laura, Jonker, Johan W & Verkade, Henkjan J (2019). LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats. Pediatric Research, 85, (pp. 1041-1047).

Mihajlovic, Milos, Hariri, Sam, Westphal, Koen C.G., Janssen, Manoe J., Oost, Miriam J., Bongiovanni, Laura, Van Den Heuvel, Lambertus P., De Bruin, Alain, Hilbrands, Luuk B. & Masereeuw, Rosalinde (03.09.2019). Safety evaluation of conditionally immortalized cells for renal replacement therapy. Oncotarget, 10 (51), (pp. 5332-5348) (17 p.).

Bongiovanni, Laura, Caposano, Francesca, Romanucci, Mariarita, Grieco, Valeria, Malatesta, Daniela, Brachelente, Chiara, Massimini, Marcella, Benazzi, Cinzia, Thomas, Rachel E. & Salda, Leonardo Della (2019). Survivin and Sox9 - Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate. Veterinary Pathology, 56 (2), (pp. 200-207).

Drescher, Hannah K, Weiskirchen, Ralf, Fülöp, Annabelle, Hopf, Carsten, de San Román, Estibaliz González, Huesgen, Pitter F, de Bruin, Alain, Bongiovanni, Laura, Christ, Annette, Tolba, René, Trautwein, Christian & Kroy, Daniela C (25.06.2019). The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH). Frontiers in Physiology, 10 (17 p.).

Martines, Anne-Claire M F, Gerding, Albert, Stolle, Sarah, Vieira-Lara, Marcel A, Wolters, Justina C, Jurdzinski, Angelika, Bongiovanni, Laura, de Bruin, Alain, van der Vlies, Pieter, van der Vries, Gerben, Bloks, Vincent W, Derks, Terry G J, Reijngoud, Dirk-Jan & Bakker, Barbara M (2019). Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Scientific Reports, 9 (1) (11 p.).

Porcellato, Ilaria, Silvestri, Serenella, Menchetti, Laura, Recupero, Francesca, Mechelli, Luca, Sforna, Monica, Iussich, Selina, Bongiovanni, Laura, Lepri, Elvio & Brachelente, Chiara (21.11.2019). Tumour-infiltrating lymphocytes in canine melanocytic tumours - An investigation on the prognostic role of CD3+ and CD20+ lymphocytic populations. Veterinary and Comparative Oncology © 2019 John Wiley & Sons Ltd..

Articles - 2018

Matondo, Ramadhan B, Moreno, Eva, Toussaint, Mathilda J M, Tooten, Peter C J, van Essen, Saskia C, van Liere, Elsbeth A, Youssef, Sameh A, Bongiovanni, Laura & de Bruin, Alain (2018). Atypical E2f functions are critical for pancreas polyploidization. PLoS One, 13 (1).

Di Girolamo, Nicola, Fecteau, Kellie, Carnimeo, Alessandra, Bongiovanni, Laura, Fracassi, Federico, Isani, Gloria & Selleri, Paolo (01.06.2018). Variability of serum aldosterone concentrations in pet ferrets (Mustela putorius furo). Journal of the American Veterinary Medical Association, 252 (11), (pp. 1372-1376) (5 p.).

Articles - 2017

Massimini, M., Palmieri, C., De Maria, R., Romanucci, M., Malatesta, D., De Martinis, M., Maniscalco, L., Ciccarelli, A., Ginaldi, L., Buracco, P., Bongiovanni, L. & Salda, L. Della (01.05.2017). 17-AAG and Apoptosis, Autophagy, and Mitophagy in Canine Osteosarcoma Cell Lines. Veterinary Pathology, 54 (3), (pp. 405-412) (8 p.).

Di Girolamo, Nicola, Bongiovanni, Laura, Ferro, Silvia, Melidone, Raffaele, Nicoletti, Annalisa, Del Duca, Valeria, Donnelly, Thomas M. & Selleri, Paolo (01.07.2017). Cystoscopic diagnosis of polypoid cystitis in two pet rabbits. Journal of the American Veterinary Medical Association, 251 (1), (pp. 84-89) (6 p.).

Romanucci, M., Massimini, M., Ciccarelli, A., Malatesta, D., Bongiovanni, L., Gasbarre, A. & Della Salda, L. (01.03.2017). HSP32 and HSP90 Immunoexpression, in Relation to Kit Pattern, Grading, and Mitotic Count in Canine Cutaneous Mast Cell Tumors. Veterinary Pathology, 54 (2), (pp. 222-225) (4 p.).

Brachelente, Chiara, Cappelli, Katia, Capomaccio, Stefano, Porcellato, Ilaria, Silvestri, Serenella, Bongiovanni, Laura, De Maria, Raffaella, Verini Supplizi, Andrea, Mechelli, Luca & Sforna, Monica (01.12.2017). Transcriptome Analysis of Canine Cutaneous Melanoma and Melanocytoma Reveals a Modulation of Genes Regulating Extracellular Matrix Metabolism and Cell Cycle. Scientific Reports, 7 (1).

Romanucci, M., Defourny, S. V.P., Massimini, M., Valerii, V., Arbuatti, A., Giordano, V., Bongiovanni, L., Perrone, C. & Della Salda, L. (01.01.2017). Unexpected Cardiac Death During Anaesthesia of a Young Rabbit Associated with Fibro-fatty Replacement of the Right Ventricular Myocardium. Journal of Comparative Pathology, 156 (1), (pp. 33-36) (4 p.).

Articles - 2016

Brachelente, C., Affolter, V. K., Fondati, A., Porcellato, I., Sforna, M., Lepri, E., Mechelli, L. & Bongiovanni, L. (01.01.2016). CD3 and CD20 Coexpression in a Case of Canine Cutaneous Epitheliotropic T-Cell Lymphoma (Mycosis Fungoides). Veterinary Pathology, 53 (3), (pp. 563-566) (4 p.).

Romanucci, M., Frattone, L., Ciccarelli, A., Bongiovanni, L., Malatesta, D., Benazzi, C., Brachelente, C. & Della Salda, L. (01.12.2016). Immunohistochemical expression of heat shock proteins, p63 and androgen receptor in benign prostatic hyperplasia and prostatic carcinoma in the dog. Veterinary and Comparative Oncology, 14 (4), (pp. 337-349) (13 p.).

Bongiovann, Laura, Di Girolamo, Nicola, Della Salda, Leonardo, Massimi, Marcella, Romanucci, Mariarita & Selleri, Paolo (01.04.2016). Sudden death in a captive meerkat (Suricata suricatta) with arterial medial and myocardial calcification. Asian Pacific Journal of Tropical Biomedicine, 6 (4), (pp. 357-359) (3 p.).

Articles - 2015

Bongiovanni, Laura, D'Andrea, Alessandra, Porcellato, Ilaria, Ciccarelli, Andrea, Malatesta, Daniela, Romanucci, Mariarita, Salda, Leonardo Della, Mechelli, Luca & Brachelente, Chiara (01.01.2015). Canine cutaneous melanocytic tumours - Significance of β-catenin and survivin immunohistochemical expression. Veterinary Dermatology, 26 (4).

Di Cesare, Angela, Di Francesco, Gabriella, Frangipane di Regalbono, Antonio, Eleni, Claudia, De Liberato, Claudio, Marruchella, Giuseppe, Iorio, Raffaella, Malatesta, Daniela, Romanucci, Maria Rita, Bongiovanni, Laura, Cassini, Rudi & Traversa, Donato (01.02.2015). Retrospective study on the occurrence of the feline lungworms Aelurostrongylus abstrusus and Troglostrongylus spp. in endemic areas of Italy. Veterinary Journal, 203 (2), (pp. 233-238) (6 p.).

Bongiovanni, L., Romanucci, M., Malatesta, D., D’Andrea, A., Ciccarelli, A. & Della Salda, L. (01.01.2015). Survivin and Related Proteins in Canine Mammary Tumors - Immunohistochemical Expression. Veterinary Pathology, 52 (2), (pp. 269-275) (7 p.).

Articles - 2014

Porcellato, Ilaria, Brachelente, Chiara, Guelfi, Gabriella, Reginato, Alice, Sforna, Monica, Bongiovanni, Laura & Mechelli, Luca (17.11.2014). A retrospective investigation on canine papillomavirus 1 (CPV1) in oral oncogenesis reveals dogs are not a suitable animal model for high-risk HPV-induced oral cancer. PLoS One, 9 (11).

Di Girolamo, Nicola, Selleri, Paolo, Nardini, Giordano, Corlazzoli, Daniele, Fonti, Paolo, Rossier, Christophe, Salda, Leonardo Della, Schilliger, Lionel, Vignoli, Massimo & Bongiovanni, Laura (01.01.2014). Computed tomography-guided bone biopsies for evaluation of proliferative vertebral lesions in two boa constrictors (Boa constrictor imperator). Journal of Zoo and Wildlife Medicine, 45 (4), (pp. 973-978) (6 p.).

Selleri, Paolo, Di Girolamo, Nicola, Vögtlin, Andrea, Fileccia, Ivan, Hoop, Richard & Bongiovanni, Laura (01.01.2014). Cutaneous lesions in pet rabbits following subcutaneous administration of a novel bivalent vaccine against myxomatosis and rabbit haemorrhagic disease. Veterinary Dermatology, 25 (6), (pp. 563-e100).

Laura, Bongiovanni, Nicola, Di Girolamo, Alessandro, Montani, Leonardo, Della Salda & Paolo, Selleri (01.01.2014). Fatal hemorrhagic-necrotizing pancreatitis associated with pancreatic and hepatic lipidosis in an obese Asian palm civet (Paradoxurus hermaphroditus). Asian Pacific Journal of Tropical Biomedicine, 4, (pp. S62-S65).

Bongiovanni, Laura, Di Diodoro, Francesca, Della Salda, Leonardo & Brachelente, Chiara (01.01.2014). On the role of survivin as a stem cell biomarker of canine hair follicle and related tumours. Veterinary Dermatology, 25 (2).

Malatesta, Daniela, Simpson, Vic R., Fusillo, Romina, Marcelli, Manlio, Bongiovanni, Laura, Romanucci, Mariarita, Palmieri, Chiara & Salda, Leonardo Della (01.01.2014). Prima descrizione di un caso di adiaspiromicosi in lontra eurasiatica (Lutra lutra) in Italia. Veterinaria italiana, 50 (3), (pp. 199-202) (4 p.).

Articles - 2013

Bongiovanni, Laura, D'Andrea, Alessandra, Romanucci, Mariarita, Malatesta, Daniela, Candolini, Melissa, Salda, Leonardo D., Mechelli, Luca, Sforna, Monica & Brachelente, Chiara (2013). Epithelial-to-mesenchymal transition - Immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours. Veterinary Dermatology, 24 (1), (pp. 195-203) (11 p.).

Romanucci, M., Berardi, I., Ciccarelli, A., Bongiovanni, L., Malatesta, D., Oevermann, A. & Della Salda, L. (01.08.2013). Immunohistochemical evaluation of heat shock protein expression in normal canine nerve and peripheral nerve sheath tumours. Journal of Comparative Pathology, 149 (2-3), (pp. 216-220) (5 p.).

Bongiovanni, L., Selleri, P. & Della Saida, L. (01.01.2013). Necrosi cutanea ed epatica in un coniglio domestico - Un caso sospetto di reazione avversa a farmaco. Acta Veterinaria Hungarica, 27 (2), (pp. 31-34) (4 p.).

Maniscalco, Lorella, Iussich, Selina, Morello, Emanuela, Martano, Marina, Biolatti, Bartolomeo, Riondato, Fulvio, Salda, Leonardo Della, Romanucci, Mariarita, Malatesta, Daniela, Bongiovanni, Laura, Tirrito, Federica, Gattino, Francesca, Buracco, Paolo & De Maria, Raffaella (01.01.2013). PDGFs and PDGFRs in canine osteosarcoma - New targets for innovative therapeutic strategies in comparative oncology. Veterinary Journal, 195 (1), (pp. 41-47) (7 p.).

Brachelente, Chiara, Porcellato, Ilaria, Sforna, Monica, Lepri, Elvio, Mechelli, Luca & Bongiovanni, Laura (2013). The contribution of stem cells to epidermal and hair follicle tumours in the dog. Veterinary Dermatology, 24 (1), (pp. 188-195) (8 p.).

Articles - 2012

Romanucci, Mariarita, Malatesta, Daniela, Ciccarelli, Andrea, Bongiovanni, Laura, Palmieri, Chiara, Borzacchiello, Giuseppe, Roperto, Franco, Altamura, Gennaro & Della Salda, Leonardo (01.11.2012). Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder. Cell Stress and Chaperones, 17 (6), (pp. 683-692) (10 p.).

Romanucci, Mariarita, D'Amato, Giuliana, Malatesta, Daniela, Bongiovanni, Laura, Palmieri, Chiara, Ciccarelli, Andrea, Buracco, Paolo, Morello, Emanuela, Maniscalco, Lorella, De Maria, Raffaella, Martano, Marina & Salda, Leonardo Della (01.01.2012). Heat shock protein expression in canine osteosarcoma. Cell Stress and Chaperones, 17 (1), (pp. 131-138) (8 p.).

Bongiovanni, Laura, Mazzocchetti, Francesca, Malatesta, Daniela, Romanucci, Mariarita, Ciccarelli, Andrea, Buracco, Paolo, De Maria, Raffaella, Palmieri, Chiara, Martano, Marina, Morello, Emanuela, Maniscalco, Lorella & Salda, Leonardo D. (11.06.2012). Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, β-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma. BMC Veterinary Research, 8.

Bongiovanni, Laura, Suter, Maja M., Malatesta, Daniela, Ordinelli, Alessandra, Ciccarelli, Andrea, Romanucci, Mariarita, Brenner, Ori & Della Salda, Leonardo (01.10.2012). Nuclear survivin expression as a potentially useful tool for the diagnosis of canine cutaneous sebaceous lesions. Veterinary Dermatology, 23 (5).

Articles - 2011

Romanucci, Mariarita, Bongiovanni, Laura, Russo, Anita, Capuccini, Silvia, Mechelli, Luca, Ordeix, Laura & Della Salda, Leonardo (01.02.2011). Oxidative stress in the pathogenesis of canine zinc-responsive dermatosis. Veterinary Dermatology, 22 (1), (pp. 31-38) (8 p.).

Bongiovanni, L., Malatesta, D., Brachelente, C., D'Egidio, S. & Della Salda, L. (01.08.2011). β-Catenin in Canine Skin - Immunohistochemical Pattern of Expression in Normal Skin and Cutaneous Epithelial Tumours. Journal of Comparative Pathology, 145 (2-3), (pp. 138-147) (10 p.).

Articles - 2009

Bongiovanni, Laura, Colombi, Isabella, Fortunato, Carmine & Salda, Leonardo Della (01.10.2009). Survivin expression in canine epidermis and in canine and human cutaneous squamous cell carcinomas. Veterinary Dermatology, 20 (5-6), (pp. 369-376) (8 p.).

Articles - 2008

Bongiovanni, Laura, Romanucci, Mariarita, Fant, Pierluigi, Lagadic, Marie & Della Salda, Leonardo (01.10.2008). Apoptosis and anti-apoptotic heat shock proteins in canine cutaneous infundibular keratinizing acanthomas and squamous cell carcinomas. Veterinary Dermatology, 19 (5), (pp. 271-279) (9 p.).

Articles - 2005

Romanucci, Mariarita, Bongiovanni, Laura, Petrizzi, Lucio & Della Salda, Leonardo (01.04.2005). Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat. Veterinary Dermatology, 16 (2), (pp. 121-124) (4 p.).

Romanucci, Mariarita, Bongiovanni, Laura, Marruchella, Giuseppe, Marà, Marino, Di Guardo, Giovanni, Preziosi, Rosario & Della Salda, Leonardo (01.04.2005). Heat shock proteins expression in canine intracutaneous cornifying epithelioma and squamous cell carcinoma. Veterinary Dermatology, 16 (2), (pp. 108-116) (9 p.).

Editorial activity - 2020

Bongiovanni, L. (2020 2021) Peer reviewer Frontiers in Veterinary Science (Journal) Research Topic:
Canine Melanoma in Comparative Oncology: Translate Research Advances to Develop New Diagnostic and Therapeutic Options
Topic Editors: Laura Bongiovanni, Chiara Brachelente, Philip Bergman, Steven Dow.

Invited talk - 2019

Bongiovanni, L. (27.09.2019) Invited speaker ESVP-ECVP conference 2019 Arnhem Liquid biopsies; The Potential Role of EVs as Biomarkers in Veterinary Medicine

Bongiovanni Laura - Attività di ricerca

 

Oncologia Veterinaria e Comparata:

 

Studio dei meccanismi di carcinogenesi, progressione e invasività tumorale nell'ambito dei tumori cutanei (carcinoma squamoso, tumori follicolari, tumori delle ghiandole sebacee, melanomi), tumori mammari, prostatici, osteosarcoma del cane.

In particolare,

 

1 - studio dell'espressione, del ruolo e del significato diagnostico/prognostico di alcune proteine antiapototiche e regolatori del ciclo cellulare (survivina, β-catenina); in particolare, studio dei meccanismi di invasività e metastatizzazione (processo di transizione epitelio-mesenchimale).

 

Pubblicazioni:

 

-          Bongiovanni L, D'Andrea A., Porcellano I., Ciccarelli A., Malatesta D., Romanucci M., Della Salda L., Mechelli L., Brachelente C. Canine cutaneous melanocytic tumours: significance of β-catenin and survivin immunohistochemical expression. Veterinary Dermatology.

-          Bongiovanni L, Romanucci M, Malatesta D, D'Andrea A, Ciccarelli A, Della Salda L.  Immunohistochemical expression of survivin and related proteins in canine mammary carcinomas. Veterinary Pathology.

-          L. Bongiovanni, A. D'Andrea, M. Romanucci, D. Malatesta, M. Candolini, L. Della Salda, L. Mechelli, M. Sforna, C. Brachelente. Epithelial to mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours. Vet Dermatol. 2013 Feb;24(1):195-e43. 

-          Bongiovanni L, Mazzocchetti F, Malatesta D, Romanucci M, Ciccarelli A, Buracco P, De Maria R, Palmieri C, Martano M, Morello E, Maniscalco L, Della Salda L.  Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, beta-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma. BMC Veterinary Research. 2012; 8(1):78.

-          Bongiovanni L, Suter M M, Malatesta D, Ordinelli A, Romanucci M, Brenner O, Della Salda L. Nuclear survivin expression as a potentially useful tool for the diagnosis of canine cutaneous sebaceous lesions. Vet Dermatol. 2012 Oct;23(5):394-e73.

-          Bongiovanni L, Müller EJ, and Della Salda L. (2011) Survivin In Skin Pathologies Experimental Dermatol. 2011; 20(6):457-63.

-          Bongiovanni L., Malatesta D., Brachelente C., D'Egidio S., Della Salda L. (2011). β-Catenin In Canine Skin: Immunohistochemical Pattern Of Expression In Normal Skin And Cutaneous Epithelial Tumors. J Comp Pathol. 2011; 145(2-3):138-47.

-          Bongiovanni L., Colombi I, Fortunato C, Della Salda L (2009). Survivin expression in canine epidermis and in canine and human cutaneous squamous cell carcinomas. Veterinary Dermatology, 20:369-376.

-          Bongiovanni L., Romanucci M, Fant P, Lagadic M, Della Salda L (2008). Apoptosis and anti-apoptotic heat shock proteins in canine cutaneous infundibular keratinizing acanthomas and squamous cell carcinomas. Veterinary Dermatology, 19(5); p. 271-279.

-          Bongiovanni L, Di Antonio M, Romanucci M, Malatesta D, Sforna M, Mechelli L, Della Salda L, Brachelente C (2011) Tumour epithelial vimentin expression in canine cutaneous squamous cell carcinoma Proceedings 29th Annual Meeting of the European Society of Veterinary Pathology, 175. 7-10 September 2011.

 

Progetti di ricerca correnti:

 

2013-2014: As one of the principal investigators, together with Dr Chiara Brachelente (University of Perugia): "Analysis of the molecular pathways involved in metastatization of canine melanoma and its applicability in the study of human melanoma". Fondazione Cassa di Risparmio di Perugia (Perugia, Italy).

 

2 - identificazione dell'espressione di alcuni marker di cellule staminali nella cute normale e in alcuni tumori cutanei (tumori follicolari, tumori delle ghiandole sebacee) e tumori prostatici del cane: Sox9, CD200, nestina, citocheratina15, survivina.

 

Pubblicazioni:

-          Bongiovanni L, Di Diodoro F, Della Salda L , Brachelente C. On The Role Of Survivin As A Stem Cell Biomarker Of Canine Hair Follicle And Related Tumours. Veterinary Dermatology. 2014 DOI: 10.1111/vde.12114.

-          C. Brachelente, I. Porcellato, M. Sforna, E. Lepri, L. Mechelli, L. Bongiovanni. Contribution of stem cells to epidermal and hair follicle tumors in the dog. Vet Dermatol. 2013 Feb;24(1):188-e41.

-          L Bongiovanni, MM Suter, A Inverso, D Malatesta, M Romanucci, L Della Salda, C Brachelente. SOX9 AND CK15: STEM CELL MARKERS IN CANINE CUTANEOUS SEBACEOUS LESIONS. Abstract accepted for the 2nd joint European Congress of the ESVP, ECVP and ESTP, Berlin, 27 to 30 August, 2014.

-          L. Bongiovanni, F. Caposano, A. Ciccarelli, M. Romanucci, D. Malatesta, C. Benazzi, C. Brachelente, M. Massimini, and L. Della Salda. CONTRIBUTION OF STEM CELLS TO BENIGN AND MALIGNANT CANINE PROSTATE TISSUES. Abstract accepted for the 2nd joint European Congress of the ESVP, ECVP and ESTP, Berlin, 27 to 30 August, 2014.

 

Progetti di ricerca:

 

1 Oct-31Dec 2014: Principal investigator, together with Prof Monika Welle (University of Bern): Identification of stem cell markers in canine hair follicle tumours. Swiss National Science Foundation - International Short Visit Program -University of Bern, Institute of Veterinary Pathology (Bern, Switzerland).

 

 

3 - Studio dei meccanismi di carcinogenesi delle neoplasie indotte da papillomavirus.

 

Pubblicazioni:

 

-          Simeone P, Romanucci M, Rizzo C, Brandi R, Malatesta D, Di Guardo G, Bongiovanni L., Della Salda L, Venuti A (2008). Papillomaviruses in Multiple Tumours of Twin Goats. The Open Veterinary Science Journal, 2; p. 33-36.

-          Porcellato I, Brachelente C, Guelfi G, Reginato A, Sforna M, Bongiovanni L, Mechelli L. A Retrospective Investigation on Canine Papillomavirus 1 (CPV1) in Oral Oncogenesis Reveals Dogs Are Not a Suitable Animal Model for High-Risk HPV-Induced Oral Cancer. PLoS One. 2014 Nov 17;9(11):e112833.

 

4 - Caratterizzazione di nuovi markers diagnostici e prognostici tumorali.

 

Pubblicazioni:

 

-          C. Brachelente, V.K. Affolter, A. Fondati, I. Porcellato, M. Sforna, E. Lepri, L. Mechelli, and L. Bongiovanni. Coexpression of CD3 and CD20 in a case of canine cutaneous epitheliotropic T cell lymphoma (mycosis fungoides) Veterinary Pathology. Sent for publication.

-          Romanucci M., Frattone L., Ciccarelli A., Bongiovanni L., Malatesta D., Benazzi C., Brachelente C., Della Salda L. Relevance of heat shock protein immunoexpression in benign and malignant canine prostate tissues. Veterinary and Comparative Oncology. 2014 Jul 25. doi: 10.1111/vco.12113.

-          M. Romanucci, I. Berardi, L. Bongiovanni, D. Malatesta, A. Ciccarelli, A. Oevermann, L. Della Salda. Heat shock protein expression in canine peripheral nerve sheath tumours. J Comp Pathol. 2013 Aug-Oct;149(2-3):216-20.

-          Romanucci Mariarita, D'Amato Giuliana, Malatesta Daniela, Bongiovanni Laura, Palmieri Chiara, Ciccarelli Andrea, Buracco Paolo, Morello Emanuela, Maniscalco Lorella, De Maria Raffaella, Martano Marina, Della Salda Leonardo. Heat shock protein expression in canine osteosarcoma. Cell Stress and Chaperones. 2012; 17(1):131-8.

 

 

Progetti di ricerca correnti:

 

2015-2017:       As one of the principal investigators: "Significato prognostico dell'espressioni immunocitochimica dei markers Ki-67 e c-Kit nel mastocitoma cutaneo del cane". Borsa di Studio SIDEV 2015 - Società Italiana Dermatologia Veterinaria.

 

 

Patologia degli animali esotici e da zoo

 

Pubblicazioni

-          Di Girolamo N, Selleri P, Cardini G, Corlazzoli D, Fonti P, Dossier C, Della Salda L, Schilliger L, Vignoli M, Bongiovanni L. CT-guided bone biopsies for evaluation of proliferative vertebral lesions in two boa constrictors (boa constrictor imperator). Journal of Zoo and Wildlife Medicine.2014 Dec;45(4):973-8.

-          Selleri P, Di Girolamo N, Vögtlin A, Fileccia I, Hoop R, Bongiovanni L. Cutaneous lesions in pet rabbits following subcutaneous administration of a novel bivalent vaccine against myxomatosis and rabbit hemorrhagic disease. Vet Dermatol. 2014 Dec;25(6):563-e100.

-          Malatesta D, Simpson VR, Fusillo R, Marcelli M, Bongiovanni L, Romanucci M, Palmieri C, Della Salda L. Pulmonary Adiaspiromycosis in an eurasian otter (lutra lutra): first description in Italy. Vet Ital. 2014 Jul-Sep;50(3):199-202. doi: 10.12834/VetIt.40.1916.8.

-          Bongiovanni L, Di Girolamo N, Montani A, Della Salda L, Selleri P. Fatal acute hemorrhagic-necrotizing pancreatitis associated with pancreatic and hepatic lipidosis in an Asian Palm Civet (Paradoxurus hermaphroditus). Asian Pac J Trop Biomed 2014; 4(1): 930-33.

-          Bongiovanni L., Selleri P., Della Salda L. Necrosi cutanea ed epatica in un coniglio domestico: un caso sospetto di reazione avversa a farmaco. (Cutaneous and hepatic necrosis in a pet rabbit: a case of suspected adverse drug reaction). Veterinaria. 2013; 27(2):31-34.

-          N. Di Girolamo, L. Bongiovanni, S. Pagliarani, S. Cristina, C. Spizzica, P. Selleri, F. Tommaso, M. Trotta. Mycobacteriosis in a pet african hedgehog (Atelerix albiventris) . International Conference on Avian Herpetology and Exotic mammal medicine, April 18-23, 2015, Paris, France.

-          Di Girolamo N, Bongiovanni L, Selleri P. Catheterization of the coccygeal vein in lizards and tail necrosis. ARAV, AEMV, AAZV Concurrent Annual Conferences, October 18-24, 2014, Orlando, Florida, USA

-          Bongiovanni L. Di Girolamo N, Selleri P. Mystery Cases in Veterinary Dermatopathology: Olivia, localised papulo-crustous dermatitis. II Joint European Congress of the ESVP, ECVP, ESTP- Berlin, 27th - 30th August 2014.

-          Selleri P., Di Girolamo N, Voetglin A, Filaccia I, Hoop R., Bongiovanni L. Atypical Myxomatous lesions in a pet rabbit following administration of a bivalent vaccine. Association of Exotic mammal veterinarians (AEMV) 2013 Annual Conference, Indianapolis, Indiana, September 14-19, 2013.

-          Di Guardo G., Marruchella G., Della Salda L., Benazzi C., Marsilio F., Zucca P., Fichtel L., Furlati S., Garcia Hartmann M., Marà M., Bongiovanni L., Iorio R., Perugini M., Ligios C., Kennedy S. Post-mortem findings in cetaceans stranded on the italian coastline. Proceedings of the 23^rd Meeting of the European Society of Veterinary Pathology (ESVP), Naples (Italy), 7/10 September 2005, p. 62.

-          Di Guardo G., Agrimi U., Delle Salda L., Terracciano G., Marruchella G., Bongiovanni L., Malatesta D., Romanucci M., Marà M., Palmieri C., Kennedy S. Morbillivirus infections in free-living sea mammals: an overview. Proceedings of the 21th Meeting of the European Society of Veterinary Pathology (2003); Dublin (Ireland), 10/13 September.