Prof. D'ADDARIO Claudio
Prof. D'ADDARIO Claudio

Email: cdaddario@unite.it

Telefono: 0861-266877

Facoltà di appartenenza: BIOSCIENZE E TECNOLOGIE AGRO-ALIMENTARI E AMBIENTALI


 
 
 
 

Curriculum accademico

 


Studi


1993 Diploma presso il Liceo Scientifico "L. da Vinci" di Pescara.
2000 Laurea in Chimica e Tecnologia Farmaceutiche, Facoltà di Farmacia Università degli Studi di Bologna,
2005 Dottore di Ricerca in Farmacologia e Tossicologia, Università degli Studi di Bologna,
2008 Diploma di studi Post-dottorato presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden


Carriera Professionale

1999 - 2000 tesi di laurea presso la "School of Medicine, National Parkinson Foundation, University of Miami", Miami, FL, USA, supervisor Prof.
Izenwasser.
2002 periodo di Ricerca presso il Dipartimento di Farmacologia e Farmacoterapia alla "Semmelweis University", Budapest, Hungary, partecipante progetto
intergovernamentale Italia-Ungheria.
2003 - 2004 Ricercatore ospite presso NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA , supervisor Prof. George R. Uhl.
2006 - 2008 Ricercatore ospite presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden, supervisor Prof. Lars
Terenius.
2007 - 2009 Participante progetto AFA presso il Karolinska Institute, Stockholm, Sweden intitolato "Molecular and neurochemical mechanisms in
alcohol dependence", Principal Investigator: Prof. Sven Ove Ogren.

2009 - 2010 Borsista post-dottorato ed assegnista senior dell' Universitá degli Studi di Bologna

da dicembre 2010 Ricercatore Biologia Molecolare (BIO/11), Facoltà di Agraria, Università degli Studi di Teramo

2013-2014 Ricercatore ospite presso il Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden

da settembre 2013 Ricercatore affiliato al Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden


Premi Ricevuti

° Vincitore Borse di Studio Marco Polo, Bologna 2003 e 2006
° Miglior Poster XIV SINPF; Bologna. 1-4 Giugno, 2004.
° Miglior Poster Premio "Emilio Marmo". 32° Congresso SIF; Napoli, 1-4 Giugno 2005.
° Vincitore della Borsa di Studio "C.M. Lerici" dell' Istituto di Cultura Italiana a Stoccolma, Settembre 2006,
° Fellowship Award 22nd ECNP Congress; Istanbul, Turkey, 12 -16 September 2009
° Miglior Poster INNOPSY09; Milano, 18-20 Novembre, 2009ù
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, ricevuto a WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.

° Miglior Poster ricerca clinica XVII SINPF; Cagliari 22-25 Settembre 2010.

° Vincitore della "C.M. Lerici" per ricercatori' Istituto di Cultura Italiana a Stoccolma, Settembre 2013,

 

Conoscenze Tecniche
- Analisi di acidi nucleici (RNA e DNA): purificazione di RNA e DNA da tessuti e cellule
- PCR, RT-PCR, Real Time PCR, primer extension
- Northern blotting e immunoblotting (Western blotting)
- Studi di Epigenetica (Chromatin Immunoprecipitation e DNA methylation)
- Pyrosequencing
- Confocal Laser Scanning Microscopy/Fluorescence Correlation Spectroscopy (CLSM/FCS) e Fluorescence Cross-Correlation Spectroscopy (FCCS)
- spettrometria di massa, analisi MALDI-TOF
- Linkage Disequilibrium analysis
- sodium dodecyl sulfatepolyacrylimide gel electrophoresis (SDS-PAGE)
- studi di Binding recettoriale
- radioimmunoassay (RIA)
- Analisi di secondi messaggeri (IP3, cAMP, Ca2+...) e secrezione di neurotrasmettitori.
- Animal Care, Animal surgery e studi comportamentali (ratti, topi)
- mantenimento di linee cellulari in coltura
- Basi di bioinformatica.

Conoscenze Linguistiche
- Inglese
- Svedese base


Curriculum english version

 

Education

1993 Scientific High School 

2000 Degree in Chemistry and Pharmaceutical Technology, Faculty of Pharmacy at the University of Bologna, Italy

2005 PhD in Pharmacology and Toxicology, University of Bologna, Italy

2008 Diploma Post-doc Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden, supervisor Prof. Lars Terenius

Experience and Occupations


1999 - 2000 period of research in the School of Medicine, National Parkinson Foundation, University of Miami, USA, joining Prof. Izenwasser
laboratory.
2002 Period of Research in the Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary, as an Italian participant of the
Italian-Hungarian Intergovernmental S&T Project.
2003 - 2004 Guest Researcher at NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA. Chief: Prof. George R. Uhl.
2006 - 2008Postdoc fellow at Department of Clinical Neuroscience - Karolinska Institutet, Stockholm (Sweden). Chief: Prof. Lars Terenius.
2007-2009Participant in the AFA project entitled "Molecular and neurochemical mechanisms in alcohol dependence", Karolinska Institutet, Stockholm (Sweden).
Principal Investigators: Sven Ove Ogren
2009 - 2010 Postdoctoral senior fellow at Department of Pharmacology, University of Bologna, Italy

since december 2010 Researcher in Molecular Biology at the University of Teramo

2013-2014 Guest Researcher Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden

since september 2013 Affiliated Reseacher Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden



Awards


° Best Poster XIV SINPF; 1-4 June, 2004, Bologna, Italy.
° Best Poster Price "Emilio Marmo". 32° Congress of the Italian Society of Pharmacology; 1-4 June 2005, Napoli, Italy.
° Research Fellowship Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2006.
° Research Fellowship of the University of Bologna "Marco Polo" for the promotion in foreign country of young researcher (2003 and 2006).
° Fellowship Award 22nd ECNP Congress. 12 -16 September 2009 Istanbul, Turkey.
° Best Poster INNOPSY09; 18-20 Novembe 2009, Milano, Italy
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.

° Best poster Clinical Research XVII SINPF; 20-24 September, 2010, Cagliari, Italy.

° Research Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2013.


Technical skills and competences
- Purification of genetic materials (DNA, RNA) from tissues and cells
- PCR, RT-PCR, Real Time PCR, primer extension
- Northern blotting e immunoblotting (Western blotting)
- Epigenetic (Chromatin Immunoprecipitation and DNA methylation)
- Pyrosequencing
- Confocal Laser Scanning Microscopy/Fluorescence Correlation Spectroscopy (CLSM/FCS) and Fluorescence Cross-Correlation Spectroscopy (FCCS)
- Mass spettrometry, analisi MALDI-TOF
- Linkage Disequilibrium analysis
- sodium dodecyl sulfatepolyacrylimide gel electrophoresis (SDS-PAGE)
- Binding studies
- radioimmunoassay (RIA)
- Second messangers analysis (IP3, cAMP, Ca2+...).
- Animal Care, Animal surgery and behavioural studies (rats and mice) (Course No. 1131, October 2-13, 2006 on Laboratory Animal Science, Karolinska Institutet,
Stockholm, Sweden)
- Cell line coltures
- Bases of bioinformatics.

Languages
- Mother tongue: italian
- English
- Basic Swedish


Pubblicazioni

 

Pubblicazioni scientifiche su riviste internazionali con Imapct Factor:

List of Peer-reviewed Publications

 

1.     Romualdi P, D'Addario C, Ferri S, Cox BM, Izenwasser S. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur. J. Pharmacol. 2001;413: 207-212

2.     Collins SL, D'Addario C, Izenwasser S. Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. Eur J Pharmacol. 2001; 426: 25-34.

3.     Collins SL, Gerdes RM, D'Addario C, Izenwasser S. Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity. Behav Pharmacol. 2001 Jul; 12(4):237-45.

4.     Collins S, D'Addario C, Romualdi P, Candeletti S, Izenwasser S. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. Neuroreport. 2002; 13: 107-109.

5.     Romualdi P, Landuzzi D, D'Addario C, Candeletti S. Modulation of proorphaninFQ/N gene expression by morphine in the rat mesocorticolimbic system. Neuroreport. 2002;13(5):645-8.

6.     Bregola G, Zucchini S, Candeletti S, Rodi D, Binaschi A, D'Addario C, Landuzzi D, Reinscheid R, Romualdi P, Simonato M. Involvement of the Neuropeptide Nociceptin/Orphanin FQ in Kainate Seizures. J. of Neuroscience. 2002; 22: 10030-10038.

7.     Di Benedetto M, D'Addario C, Collins S, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. J. Mol. Neurosci. 2004; 22: 213-222.

8.     D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Differential time course of the effects of Kappa-Opioid agonist treatment on dynorphin A levels and on Kappa-Opioid receptor density. J. Mol. Neurosci. 2004; 24: 307-314.

9.     Di Benedetto M, D'Addario C, Feliciani D, Izenwasser S, Candeletti S, Romualdi P. Effects of the selective norepinephrine uptake inhibitor on the prodynorphin gene expression in rat CNS. Mol. Brain Res. 2004; 127: 115-120.

10.  D'Addario C, Di Benedetto M, Candeletti S, Romualdi P, Effects of MDMA administration on the prodynorphin system activity in the rat brain, Neuroscience 2006; 137: 187-196.

11.  Drgon T, D'Addario C, Uhl GR, Linkage Disequilibrium and haplotype analysis of polymorphisms in the GABA receptor cluster on chromosome 4: association study, Am J Med Genet B Neuropsychiatr Genet. 2006; 141: 854-860.

12.  Király KP, Riba P, D'Addario C, Di Benedetto M, Candeletti S, Romualdi P and Furst, Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxy-metopon and oxycodone-6-oxime, Brain Res. Bull, 2006; 70: 233-239.

13.  D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS, Neuroscience 2007; 144: 157-164.

14.  Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Alterations of CREB and DARPP-32 activation following cocaine and monoaminergic uptake inhibitors, Brain Res. 2007; 1128: 33-39.

15.  D'Addario C, Di Benedetto M, Candeletti S, Romualdi P. The k-opioid receptor agonist U-69593 prevents cocaine-induced DARPP-32 activation in the rat brain, Brain Res. Bull, 2007; 73: 34-9.

16.  Romualdi P, Di Benedetto M, D'Addario C, Collins SL, Wade D, Candeletti S, Izenwasser S, Chronic cocaine produces decreases in nociceptin in select brain regions. J Mol Neurosci. 2007; 31: 159-164

17.  Vukojevic V, Ming Y, D'Addario C, Johansson B, Rigler R, Terenius L. Fluorescence Correlation Spectroscopy (FCS) study of mu-opioid receptor dynamics in live cells; FEBS JOURNAL Volume: 274 Pages: 107-107, 2007

18.  D'Addario C§, Ming Y, Ögren SO, Terenius L, Effects of Ethanol and Role of Acetaldehyde on the Expression of endogenous opioid System Genes in SH-SY5Y Cells. FASEB J, 2008; 22: 662-670. § corresponding author

19.  Vukojević V, Ming Y, D'Addario C, Rigler R, Johansson B, Terenius L. Ethanol/naltrexone interactions at the mu-opioid receptor. CLSM/FCS study in live cells. PLoS One. 2008;3(12):e4008.

20.  Vukojević V, Ming Y, D'Addario C, Hansen M, Langel U, Schulz R, Johansson B, Rigler R, Terenius L. Mu-opioid receptor activation in live cells. FASEB J. 2008 Oct;22(10):3537-48.

21.  Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O. The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res. 2008 Dec 16;195(1):54-77.

22.  Di Benedetto M, Cavina C, D'Addario C, Leoni G, Candeletti S, Cox BM, Romualdi P. Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. Neuropharmacology. 2009 Mar;56(4):761-77

23.  D'Addario C§, Johansson S, Romualdi P, Ogren SO, Terenius L, Ekstrom TJ. Epigenetic effects of ethanol and acetaldehyde exposure in the prodynorphin gene promoter in a human neuroblastoma cell line. FASEB J 2011 Mar;25(3):1069-75. § corresponding author

24.  Di Benedetto M, Bastías Candia SC, D'Addario C Porticella E, Cavina C, Candeletti S and Romualdi P.Regulation of opioid genes expression in the rat brainstem by 3,4-Methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade Naunyn-Schmiedeberg Archives of Pharmacology 2011383(2):169-78

25.  D'Addario C§, Caputi FF, Candeletti S, Rimondini R, Romualdi P. Different Alcohol exposures induce selective alterations on the expression of Dynorphin and Nociceptin Systems Related Genes in Rat Brain. Addiction Biology 18(3):425-33. § corresponding author

26.  D'Addario, C§; Caputi, FF; Candeletti, S; et al. A role for epigenetic mechanisms in the regulation of prodynorphin expression by alcohol. Pharmacological Reports 2011; 63: 208-209. § corresponding author

27.  Di Benedetto, M; D'Addario, C§; Dell'Osso, B; et al. Investigation on DNA methylation status of opioid peptides promoters in PBMCs of subjects with bipolar disorder Pharmacological Reports 2011; 63: 263-264. § corresponding author

28.  Arosio B*, Bulbarelli A, Bastias Candia S, Lonati E, Mastronardi L, Romualdi P, Candeletti S, Gussago  C, Galimberti D, Scarpini E, Dell'Osso B, Altamura AC, Maccarrone M, Bergamaschini L, D'Addario C*, Mari D. Pin1 Contribution to Alzheimer's Disease: Transcriptional and Epigenetic Mechanisms in Patients with Late-Onset Alzheimer's Disease. * equal contribution. Neurodegenerative Dis 2012; 10: 207-211.

29.  D'Addario C§, Dell'Osso B, Palazzo MC, Benatti B, Lietti L, Cattaneo E, Galimberti D, Fenoglio C,  Cortini F, Scarpini E, Arosio B, Di Francesco A, Di Benedetto M,  Romualdi P, Candeletti S, Mari D, Bergamaschini L, Bresolin N, Maccarrone M, Altamura AC. Selective DNA methylation of BDNF promoter in Bipolar Disorder: differences among patients with BDI and BDII. Neuropsychopharmacology 2012 37: 1647-1655. § corresponding author

30.  D'Addario C§, Di Francesco A, Arosio B, Gussago C, Dell'osso B, Bari M, Galimberti D, Scarpini E, Altamura AC, Mari D, Maccarrone M§. Epigenetic regulation of Fatty Acid amide hydrolase in Alzheimer disease. PLoS One. 2012;7(6):e39186. § corresponding author

31.  Maccarrone M*, D'Addario C*, Di Francesco A, Trabace L, Finazzi Agrò A, Cuomo V Modulation of the endocannabinoid system in Alzheimer's disease. * equal contribution. European J of Neurodeg dis 1, 67-78.

32.  Galimberti D, D'Addario C, Dell'osso B, Fenoglio C, Marcone A, Cerami C, Cappa SF, Palazzo MC, Arosio B, Mari D, Maccarrone M, Bresolin N, Altamura AC, Scarpini E. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Neurol Sci. 2013 Jun;34(6):899-903

33.  D'Addario C§, Caputi FF, Ekström TJ, Di Benedetto M, Maccarrone M, Romualdi P, Candeletti S. Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci. 2013; 49(2):312-9. § corresponding author

34.  D'Addario C§, Dell'Osso B§, Galimberti D, Palazzo MC, Benatti B, Di Francesco A, Altamura AC, Maccarrone M. Epigenetic Modulation of BDNF gene in Patients with Major Depressive Disorder. Biol Psych 2013 Jan 15;73(2):e6-7. § corresponding authors

35.  D'Addario C§, Di Francesco A, Pucci M, Finazzi Agrò A, Maccarrone M§. Epigenetic mechanisms and endocannabinoid signalling. FEBS J. 2013 May; 280(9):1905-17. § corresponding author

36.  Di Francesco A, Arosio B, Gussago C, Dainese E, Mari D, D'Addario C§, Maccarrone M*. J Alzheimers Dis. 2013;37(1):3-8. Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation. § corresponding authors

37.  Pucci M, Rapino C, Di Francesco A, Dainese E, D'Addario C§, Maccarrone M§. Epigenetic control of skin differentiation genes by phytocannabinoids. Br J Pharmacol. 2013 Oct;170(3):581-91. § corresponding authors

38.  Caputi FF, Di Benedetto M, Carretta D, Bastias del Carmen Candia S, D'Addario C, Cavina C, Candeletti S, Romualdi P. Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:36-46.

39.  Bastías-Candia S, Di Benedetto M, D'Addario C, Candeletti S, Romualdi P. Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease. Environ Toxicol. 2013 Dec 23. doi: 10.1002/tox.21943.

40.  D' Addario C§, Di Francesco A, Trabace L, Finazzi Agro' A, Cuomo V, Maccarrone M§. Endocannabinoid signaling in Alzheimer's disease: current knowledge and future directions. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2 Suppl):61-73.

41.  Arosio B*, D'Addario C*, Gussago C, Casati M, Tedone E, Ferri E, Nicolini P, Rossi PD, Maccarrone M, Mari D. Peripheral blood mononuclear cells as alaboratory to study dementia in the elderly. Biomed Res Int. 2014;2014:169203. * equal contribution

42.  Dell'Osso B*§, D'Addario C*§, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Di Francesco A, Maccarrone M, Altamura AC. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014 Sep;166:330-3. * equal contribution

43.  D'Addario C§, Micioni Di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M§. Endocannabinoid signaling and food addiction. Neurosci Biobehav Rev. 2014 Aug 27;47C:203-224.

44. Di Francesco A, Falconi A, Di Germanio C, Micioni Di Bonaventura MV, Costa A, Caramuta S, Del Carlo M, Compagnone D, Dainese E, Cifani C, Maccarrone M, D'Addario C. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J Nutr Biochem. 2015 Mar;26(3):250-

45. Di Francesco A, Arosio B, Falconi A, Micioni Di Bonaventura MV, Karimi M, Mari D, Casati M, Maccarrone M, D'Addario C. Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells. Brain Behav Immun. 2015 Mar;45:139-44

46. Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D'Addario C. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addict Biol. 2015 Sep 21. doi: 10.1111/adb.12303.

47. Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P. Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015 Oct 1;155:68-75.

48. Cifani C, Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Di Francesco A, Maccarrone M, D'Addario C. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? Front Neurosci. 2015 Jun 8;9:187.

49. Mancino S, Burokas A, Gutiérrez-Cuesta J, Gutiérrez-Martos M, Martín-García E, Pucci M, Falconi A, D'Addario C, Maccarrone M, Maldonado R. Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior. Neuropsychopharmacology. 2015 May 6. doi: 10.1038/npp.2015.129.

49. Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D'Addario C. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addict Biol. 2016, 21(6):1168-1185.

50. Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P.Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015; 155: 68-75.

51. Pucci M, D'Addario C. Assessing Gene Expression of the Endocannabinoid System.

Methods Mol Biol. 2016;1412:237-46. doi: 10.1007/978-1-4939-3539-0_24.

52. Ferri E, Arosio B, D'Addario C, Galimberti D, Gussago C, Pucci M, Casati M, Fenoglio C, Abbate C, Rossi PD, Scarpini E, Maccarrone M, Mari D. Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. J Neurol Sci. 2016 Mar 15;362:283-6.

53. Catanzaro G, Pucci M, Viscomi MT, Lanuti M, Feole M, Angeletti S, Grasselli G, Mandolesi G, Bari M, Centonze D, D'Addario C, Maccarrone M. Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis. J Neuroimmunol. 2016 May 15;294:32-40.

54. Zoratto F, Romano E, Pascale E, Pucci M, Falconi A, Dell'Osso B, Maccarrone M, Laviola G, D'Addario C, Adriani W. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. Neuroscience. 2017 Jan 6;340:101-116.

55. D'Addario C, Shchetynsky K, Pucci M, Cifani C, Gunnar A, Vukojević V, Padyukov L, Terenius L. Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Mar 21;76:195-203.

56. D'Addario C, Micale V, Di Bartolomeo M, Stark T, Pucci M, Sulcova A, Palazzo M, Babinska Z, Cremaschi L, Drago F, Carlo Altamura A, Maccarrone M, Dell'Osso B. A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia. Schizophr Res. 2017 Jan 17. pii: S0920-9964(17)30031-2.

57. D'Addario C, Candia SB, Arosio B, Di Bartolomeo M, Abbate C, Casè A, Candeletti S, Romualdi P, Damanti S, Maccarrone M, Bergamaschini L, Mari D. Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer's disease, a case report. J Neurol Sci. 2017 Jan 15;372:211-216. doi: 10.1016/j.jns.2016.11.052.

 

 

 

Prodotti della ricerca

 

1)     D'Addario C, Vukojevic V, Ekstrom T, Romualdi P, Ogren SO, Terenius L. A new approach to study alcoholism: molecular imaging and epigenetic analysis of ethanol dependence mechanisms. 3rd International Forum Innovation in Psychiatry. November 18-20th 2009, Milan. POSTER AWARD

2)     D'Addario C, Candeletti S, Romualdi P. Basal expression of endogenous opioid genes in mice neuronal tissues involved in pain control. 34° Congresso Nazionale della Società Italiana di Farmacologia, Rimini, 14-17 Ottobre 2009. P 1/5/1

3)     D'Addario C, Caputi FF, Candeletti S, Vukojevic V, Ogren SO, Terenius L. New Insight for a therapeutical approach to alcoholism: study of toxicity, tolerance and ethanol dependence mechanisms by regulation of transcription, molecular imaging, and epigenetic analysis.  34° Congresso Nazionale della Società Italiana di Farmacologia, Rimini, 14-17 Ottobre 2009. C 2/6/6

4)     D'Addario C, Ekstrom TJ, Ogren SO, Romualdi P, Terenius L. Prodynorphin gene regulation by epigenetic mechanisms following ethanol and acetaldehyde exposure in SH-SY5Y cells. 22nd European College of Neuropsychopharmacology Congress, 12-16 September 2009, Istanbul P6 b 008. FELLOWSHIP AWARD

5)     D'Addario C, Ming Y, Ogren SO, Terenius L. Effects of ethanol and acetaldehyde on the expression of the endogenous opioid system genes in SH-SY5Y cells. 36° INRC, Berlin, 8-13 July 2007.

6)     Di Benedetto M, D'Addario C, Candeletti S, Romualdi P. Role of CREB in the prodynorphin gene expression regulation by MDMA. 36° INRC, Berlin, 8-13 July 2007.

7)     Vukojevic V, Ming Y, D'Addario C, Johansson B, Terenius L. Intracellular trafficking of the mu-opioid receptor. 9 th Carl Zeiss sponsored workshop on Fluorescence Correlation Spectroscopy and related methods, 4-6 December 2006, p. 29.

8)     D'Addario C, Drgon T, Romualdi P, Uhl GR, Linkage Disequilibrium and haplotype analysis of polymorphisms in the GABA receptor cluster on chromosome 4: association study. XI Convegno monotematico SIF, Neurofarmacologia e Neurobiologia delle dipendenze, Bologna, 9/9/2005, p. 47.

9)     Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Effects of 3,4-Methylendioxy-N-methylamphetamine (MDMA, "ecstasy") administration on the dynorphinergic system in the rat brain. XI Convegno monotematico SIF, Neurofarmacologia e Neurobiologia delle dipendenze, Bologna, 9/9/2005, p. 40.

10)  Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Role of different neurotransmitters on cocaine-mediated effects on prodynorphin gene expression and CREB activation in the rat brain. XI Convegno monotematico SIF, Neurofarmacologia e Neurobiologia delle dipendenze, Bologna, 9/9/2005, p. 39.

11)  Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Possible role of nociception/OFQ-NOP system in experimental models of Parkinson's disease. 32° Congresso Nazionale della Società Italiana di Farmacologia Napoli, 1-4 Giugno 2005. BEST POSTER WINNER Premio "Emilio Marmo".

12)  D'Addario C, Di Benedetto M, Candeletti S, Romualdi P, Involvement of serotini in dynorphinergic system regulation by kappa-opioid agonist and cocaina treatments. 32° Congresso Nazionale della Società Italiana di Farmacologia Napoli, 1-4 Giugno 2005.

13)  C. D'Addario. VIII National Congress for PhD students in Pharmacology, Siena (Italy), September 24-27, 2004.

14)  M. Di Benedetto, D. Landuzzi, C. D'Addario, G. Lopetuso, S. Candeletti, P. Romualdi, Alterations in prodynorphin gene expression in 6-OHDA lesioned rat brain. XIV SINPF Bologna, June 1-4, 2004.  BEST POSTER WINNER

15)  K. Királi, C. D'Addario, M. Di Benedetto, D. Landuzzi, P. Riba, S. Candeletti, P. Romualdi, S. Fürst, Alterations of the dynorphinergic system during tolerance development in rat brain by novel opioid compounds. EOC, Visegrad, Hungary, April -7, 2004, p.23.

16)  Simonato M., Aparicio L., Bregola G., Zucchini S., Rodi D., Binaschi A., Mazzuferi M., D'Addario C., Landuzzi D., Di Benedetto M., Reinscheid R., Romualdi P. Candeletti S.: Involvement of the Neuropeptide Nociceptin/Orphanin FQ in Kainate Seizures. XLVI Congreso Nacional de Ciencias Fisiologicas. Aguascalientes, Mexico, 3-6 Agosto 2003.

17)  P. Romualdi, C. D'Addario, M. Di Benedetto, S. Izenwasser, S. Candeletti, Differential time corse of the effects of kappa-opioid agonist treatment on dynorphin A and on kappa-opioid receptor density. 34° INRC, Perpignan, France, July 6-11, 2003, p. 70.

18)  S. Candeletti, D. Landuzzi, C. D'Addario, M. Di Benedetto, P. Romualdi, Chronic morphine markedly affects the NOCICEPTIN/ORPHANIN FQ system in the rat hippocampus. 34° INRC, Perpignan, France, July 6-11, 2003, p. 78.

19)  D. Landuzzi, C. D'Addario, M. Di Benedetto, A. Cevolani, P. Romualdi, S. Candeletti, Hippocampal N/OFQ and NOP receptor alterations induced by morphin tolerance. XXXI SIF, Trieste (Italy) June 26-29, 2003.

20)  M. Di Benedetto, C. D'Addario, D. Feliciani, S. Candeletti, P. Romualdi, Effects of chronic treatment with nisoxetine on prodynorphin gene expression in rat CNS. XXXI SIF, Trieste (Italy) June 26-29, 2003.

21)  S.L. Collins, C. D'Addario, P. Romualdi, S. Candeletti, S. Izenwasser. Regulation of dynorphin gene expression by kappa-opioid agonists and cocaine. 33° INRC, Asilomar, Pacific Grove, CA (USA), July 9-14, 2002, p. 70.

22)  S. Izenwasser, S. Candeletti, C. D'Addario, M. Di Benedetto, S.L. Collins, P. Romualdi. Depletion of serotonin blocks the regulation of dynorphin by kappa-opioid agonists. 33° INRC, Asilomar, Pacific Grove, CA (USA), July 9-14, 2002, p. 31.

23)  C. D'Addario, S. Izenwasser, P. Romualdi, S. Candeletti. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. Capri (Italy), September 20, 2002.

24)  C. D'Addario. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. VI National Congress for PhD students in Pharmacology, Siena (Italy), September 23-26, 2002.

25)  S. Izenwasser, C. D'Addario, S. Candeletti, S.L. Collins, M. Di Benedetto, and P. Romualdi. Cocaine and fluoxetine produce opposite effects on dynorphin gene expression. 32° SFN, Orlando, CA (USA), Novembre 2-7, 2002, program number 608.10.

26)  C. D'Addario. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. V National Congress for PhD students in Pharmacology, Siena (Italy), September 24-27, 2001.

27)  S. Candeletti, D. Landuzzi, C. D'Addario, P. Romualdi. Acute and chronic morphine affect proOFQ/N gene expression in different rat brain areas. XXX SIF, Genova (Italy), May 30- June 2, 2001.

28)  C. D'Addario, D. Landuzzi, E. Fusconi, P. Romualdi, S. Candeletti, Biosynthesis alterations of proOFQ/N after acute and chronic morphine in rat CNS. VII National Congress of young neuroscientists, Pisa (Italy), 5-7 December 2000, p.54.

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Ultimo aggiornamento: 05-10-2017
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