Email:
cdaddario@unite.it
Telefono: 0861-266877
Facoltà di appartenenza: BIOSCIENZE E TECNOLOGIE AGRO-ALIMENTARI E AMBIENTALI
Studi
1993 Diploma presso il Liceo Scientifico "L. da Vinci" di Pescara.
2000 Laurea in Chimica e Tecnologia Farmaceutiche, Facoltà di Farmacia Università degli Studi di Bologna,
2005 Dottore di Ricerca in Farmacologia e Tossicologia, Università degli Studi di Bologna,
2008 Diploma di studi Post-dottorato presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden
Carriera Professionale
1999 - 2000 tesi di laurea presso la "School of Medicine, National Parkinson Foundation, University of Miami", Miami, FL, USA, supervisor Prof.
Izenwasser.
2002 periodo di Ricerca presso il Dipartimento di Farmacologia e Farmacoterapia alla "Semmelweis University", Budapest, Hungary, partecipante progetto
intergovernamentale Italia-Ungheria.
2003 - 2004 Ricercatore ospite presso NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA , supervisor Prof. George R. Uhl.
2006 - 2008 Ricercatore ospite presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden, supervisor Prof. Lars
Terenius.
2007 - 2009 Participante progetto AFA presso il Karolinska Institute, Stockholm, Sweden intitolato "Molecular and neurochemical mechanisms in
alcohol dependence", Principal Investigator: Prof. Sven Ove Ogren.
2009 - 2010 Borsista post-dottorato ed assegnista senior dell' Universitá degli Studi di Bologna
da dicembre 2010 Ricercatore Biologia Molecolare (BIO/11), Facoltà di Agraria, Università degli Studi di Teramo
2013-2014 Ricercatore ospite presso il Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden
Novembre 2019 Guest Professor, University of Cordoba, Cordoba, Argentina.
da settembre 2013 Ricercatore affiliato al Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden
da gennaio 2019 Professore Associato di Biologia Molecolare (BIO/11), Facoltà di Bioscienze, Università degli Studi di Teramo
Premi Ricevuti
° Vincitore Borse di Studio Marco Polo, Bologna 2003 e 2006
° Miglior Poster XIV SINPF; Bologna. 1-4 Giugno, 2004.
° Miglior Poster Premio "Emilio Marmo". 32° Congresso SIF; Napoli, 1-4 Giugno 2005.
° Vincitore della Borsa di Studio "C.M. Lerici" dell' Istituto di Cultura Italiana a Stoccolma, Settembre 2006,
° Fellowship Award 22nd ECNP Congress; Istanbul, Turkey, 12 -16 September 2009
° Miglior Poster INNOPSY09; Milano, 18-20 Novembre, 2009ù
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, ricevuto a WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.
° Miglior Poster ricerca clinica XVII SINPF; Cagliari 22-25 Settembre 2010.
° Vincitore della "C.M. Lerici" per ricercatori' Istituto di Cultura Italiana a Stoccolma, Settembre 2013,
Conoscenze Tecniche
- Analisi di acidi nucleici (RNA e DNA): purificazione di RNA e DNA da tessuti e cellule
- PCR, RT-PCR, Real Time PCR, primer extension
- Northern blotting e immunoblotting (Western blotting)
- Studi di Epigenetica (Chromatin Immunoprecipitation e DNA methylation)
- Pyrosequencing
- Confocal Laser Scanning Microscopy/Fluorescence Correlation Spectroscopy (CLSM/FCS) e Fluorescence Cross-Correlation Spectroscopy (FCCS)
- spettrometria di massa, analisi MALDI-TOF
- Linkage Disequilibrium analysis
- sodium dodecyl sulfatepolyacrylimide gel electrophoresis (SDS-PAGE)
- studi di Binding recettoriale
- radioimmunoassay (RIA)
- Analisi di secondi messaggeri (IP3, cAMP, Ca2+...) e secrezione di neurotrasmettitori.
- Animal Care, Animal surgery e studi comportamentali (ratti, topi)
- mantenimento di linee cellulari in coltura
- Basi di bioinformatica.
Conoscenze Linguistiche
- Inglese
- Svedese base
What do you want to do ? New mailCopy
What do you want to do ? New mailCopyEducation
1993 Scientific High School
2000 Degree in Chemistry and Pharmaceutical Technology, Faculty of Pharmacy at the University of Bologna, Italy
2005 PhD in Pharmacology and Toxicology, University of Bologna, Italy
2008 Diploma Post-doc Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden, supervisor Prof. Lars Terenius
Experience and Occupations
1999 - 2000 period of research in the School of Medicine, National Parkinson Foundation, University of Miami, USA, joining Prof. Izenwasser
laboratory.
2002 Period of Research in the Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary, as an Italian participant of the
Italian-Hungarian Intergovernmental S&T Project.
2003 - 2004 Guest Researcher at NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA. Chief: Prof. George R. Uhl.
2006 - 2008Postdoc fellow at Department of Clinical Neuroscience - Karolinska Institutet, Stockholm (Sweden). Chief: Prof. Lars Terenius.
2007-2009Participant in the AFA project entitled "Molecular and neurochemical mechanisms in alcohol dependence", Karolinska Institutet, Stockholm (Sweden).
Principal Investigators: Sven Ove Ogren
2009 - 2010 Postdoctoral senior fellow at Department of Pharmacology, University of Bologna, Italy
since december 2010 Researcher in Molecular Biology at the University of Teramo
November 2019 Guest Professor, University of Cordoba, Cordoba, Argentina.
2013-2014 Guest Researcher Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden
since september 2013 Affiliated Reseacher Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden
since January 2019 Associate Professor Molecular Biology, University of Teramo
Awards
° Best Poster XIV SINPF; 1-4 June, 2004, Bologna, Italy.
° Best Poster Price "Emilio Marmo". 32° Congress of the Italian Society of Pharmacology; 1-4 June 2005, Napoli, Italy.
° Research Fellowship Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2006.
° Research Fellowship of the University of Bologna "Marco Polo" for the promotion in foreign country of young researcher (2003 and 2006).
° Fellowship Award 22nd ECNP Congress. 12 -16 September 2009 Istanbul, Turkey.
° Best Poster INNOPSY09; 18-20 Novembe 2009, Milano, Italy
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.
° Best poster Clinical Research XVII SINPF; 20-24 September, 2010, Cagliari, Italy.
° Research Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2013.
Technical skills and competences
- Purification of genetic materials (DNA, RNA) from tissues and cells
- PCR, RT-PCR, Real Time PCR, primer extension
- Northern blotting e immunoblotting (Western blotting)
- Epigenetic (Chromatin Immunoprecipitation and DNA methylation)
- Pyrosequencing
- Confocal Laser Scanning Microscopy/Fluorescence Correlation Spectroscopy (CLSM/FCS) and Fluorescence Cross-Correlation Spectroscopy (FCCS)
- Mass spettrometry, analisi MALDI-TOF
- Linkage Disequilibrium analysis
- sodium dodecyl sulfatepolyacrylimide gel electrophoresis (SDS-PAGE)
- Binding studies
- radioimmunoassay (RIA)
- Second messangers analysis (IP3, cAMP, Ca2+...).
- Animal Care, Animal surgery and behavioural studies (rats and mice) (Course No. 1131, October 2-13, 2006 on Laboratory Animal Science, Karolinska Institutet,
Stockholm, Sweden)
- Cell line coltures
- Bases of bioinformatics.
Languages
- Mother tongue: italian
- English
- Basic Swedish
What do you want to do ? New mailCopy
What do you want to do ? New mailCopyPubblicazioni scientifiche su riviste internazionali con Imapct Factor:
List of Peer-reviewed Publications
Romualdi P, D'Addario C, Ferri S, Cox BM, Izenwasser S. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur. J. Pharmacol. 2001;413: 207-212
Collins SL, D'Addario C, Izenwasser S. Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. Eur J Pharmacol. 2001; 426: 25-34.
Collins SL, Gerdes RM, D'Addario C, Izenwasser S. Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity. Behav Pharmacol. 2001 Jul; 12(4):237-45.
Collins S, D'Addario C, Romualdi P, Candeletti S, Izenwasser S. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. Neuroreport. 2002; 13: 107-109.
Romualdi P, Landuzzi D, D'Addario C, Candeletti S. Modulation of proorphaninFQ/N gene expression by morphine in the rat mesocorticolimbic system. Neuroreport. 2002;13(5):645-8.
Bregola G, Zucchini S, Candeletti S, Rodi D, Binaschi A, D'Addario C, Landuzzi D, Reinscheid R, Romualdi P, Simonato M. Involvement of the Neuropeptide Nociceptin/Orphanin FQ in Kainate Seizures. J. of Neuroscience. 2002; 22: 10030-10038.
Di Benedetto M, D'Addario C, Collins S, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. J. Mol. Neurosci. 2004; 22: 213-222.
D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Differential time course of the effects of Kappa-Opioid agonist treatment on dynorphin A levels and on Kappa-Opioid receptor density. J. Mol. Neurosci. 2004; 24: 307-314.
Di Benedetto M, D'Addario C, Feliciani D, Izenwasser S, Candeletti S, Romualdi P. Effects of the selective norepinephrine uptake inhibitor on the prodynorphin gene expression in rat CNS. Mol. Brain Res. 2004; 127: 115-120.
D'Addario C, Di Benedetto M, Candeletti S, Romualdi P, Effects of MDMA administration on the prodynorphin system activity in the rat brain, Neuroscience 2006; 137: 187-196.
Drgon T, D'Addario C, Uhl GR, Linkage Disequilibrium and haplotype analysis of polymorphisms in the GABA receptor cluster on chromosome 4: association study, Am J Med Genet B Neuropsychiatr Genet. 2006; 141: 854-860.
Király KP, Riba P, D'Addario C, Di Benedetto M, Candeletti S, Romualdi P and Furst, Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxy-metopon and oxycodone-6-oxime, Brain Res. Bull, 2006; 70: 233-239.
D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS, Neuroscience 2007; 144: 157-164.
Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Alterations of CREB and DARPP-32 activation following cocaine and monoaminergic uptake inhibitors, Brain Res. 2007; 1128: 33-39.
D'Addario C, Di Benedetto M, Candeletti S, Romualdi P. The k-opioid receptor agonist U-69593 prevents cocaine-induced DARPP-32 activation in the rat brain, Brain Res. Bull, 2007; 73: 34-9.
Romualdi P, Di Benedetto M, D'Addario C, Collins SL, Wade D, Candeletti S, Izenwasser S, Chronic cocaine produces decreases in nociceptin in select brain regions. J Mol Neurosci. 2007; 31: 159-164
Vukojevic V, Ming Y, D'Addario C, Johansson B, Rigler R, Terenius L. Fluorescence Correlation Spectroscopy (FCS) study of mu-opioid receptor dynamics in live cells; FEBS JOURNAL Volume: 274 Pages: 107-107, 2007.
D'Addario C§, Ming Y, Ögren SO, Terenius L, Effects of Ethanol and Role of Acetaldehyde on the Expression of endogenous opioid System Genes in SH-SY5Y Cells. FASEB J, 2008; 22: 662-670. § corresponding author
Vukojević V, Ming Y, D'Addario C, Rigler R, Johansson B, Terenius L. Ethanol/naltrexone interactions at the mu-opioid receptor. CLSM/FCS study in live cells. PLoS One. 2008;3(12):e4008.
Vukojević V, Ming Y, D'Addario C, Hansen M, Langel U, Schulz R, Johansson B, Rigler R, Terenius L. Mu-opioid receptor activation in live cells. FASEB J. 2008 Oct;22(10):3537-48.
Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O. The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res. 2008 Dec 16;195(1):54-77.
Di Benedetto M, Cavina C, D'Addario C, Leoni G, Candeletti S, Cox BM, Romualdi P. Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. Neuropharmacology. 2009 Mar;56(4):761-77.
D'Addario C§, Johansson S, Romualdi P, Ogren SO, Terenius L, Ekstrom TJ. Epigenetic effects of ethanol and acetaldehyde exposure in the prodynorphin gene promoter in a human neuroblastoma cell line. FASEB J 2011 Mar;25(3):1069-75. § corresponding author
Di Benedetto M, Bastías Candia SC, D'Addario C Porticella E, Cavina C, Candeletti S and Romualdi P.Regulation of opioid genes expression in the rat brainstem by 3,4-Methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade Naunyn-Schmiedeberg Archives of Pharmacology 2011383(2):169-78.
D'Addario C§, Caputi FF, Candeletti S, Rimondini R, Romualdi P. Different Alcohol exposures induce selective alterations on the expression of Dynorphin and Nociceptin Systems Related Genes in Rat Brain. Addiction Biology 18(3):425-33. § corresponding author
D'Addario, C§; Caputi, FF; Candeletti, S; et al. A role for epigenetic mechanisms in the regulation of prodynorphin expression by alcohol. Pharmacological Reports 2011; 63: 208-209. § corresponding author
Di Benedetto, M; D'Addario, C§; Dell'Osso, B; et al. Investigation on DNA methylation status of opioid peptides promoters in PBMCs of subjects with bipolar disorder Pharmacological Reports 2011; 63: 263-264. § corresponding author
Arosio B*, Bulbarelli A, Bastias Candia S, Lonati E, Mastronardi L, Romualdi P, Candeletti S, Gussago C, Galimberti D, Scarpini E, Dell’Osso B, Altamura AC, Maccarrone M, Bergamaschini L, D’Addario C*, Mari D. Pin1 Contribution to Alzheimer’s Disease: Transcriptional and Epigenetic Mechanisms in Patients with Late-Onset Alzheimer’s Disease. * equal contribution. Neurodegenerative Dis 2012; 10: 207-211.
D'Addario C§, Dell'Osso B, Palazzo MC, Benatti B, Lietti L, Cattaneo E, Galimberti D, Fenoglio C, Cortini F, Scarpini E, Arosio B, Di Francesco A, Di Benedetto M, Romualdi P, Candeletti S, Mari D, Bergamaschini L, Bresolin N, Maccarrone M, Altamura AC. Selective DNA methylation of BDNF promoter in Bipolar Disorder: differences among patients with BDI and BDII. Neuropsychopharmacology 2012 37: 1647-1655. § corresponding author
D'Addario C§, Di Francesco A, Arosio B, Gussago C, Dell'osso B, Bari M, Galimberti D, Scarpini E, Altamura AC, Mari D, Maccarrone M§. Epigenetic regulation of Fatty Acid amide hydrolase in Alzheimer disease. PLoS One. 2012;7(6):e39186. § corresponding author
Maccarrone M*, D’Addario C*, Di Francesco A, Trabace L, Finazzi Agrò A, Cuomo V Modulation of the endocannabinoid system in Alzheimer’s disease. * equal contribution. European J of Neurodeg dis 1, 67-78.
Galimberti D, D'Addario C, Dell'osso B, Fenoglio C, Marcone A, Cerami C, Cappa SF, Palazzo MC, Arosio B, Mari D, Maccarrone M, Bresolin N, Altamura AC, Scarpini E. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Neurol Sci. 2013 Jun;34(6):899-903
D'Addario C§, Caputi FF, Ekström TJ, Di Benedetto M, Maccarrone M, Romualdi P, Candeletti S. Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci. 2013; 49(2):312-9. § corresponding author
D’Addario C§, Dell’Osso B§, Galimberti D, Palazzo MC, Benatti B, Di Francesco A, Altamura AC, Maccarrone M. Epigenetic Modulation of BDNF gene in Patients with Major Depressive Disorder. Biol Psych 2013 Jan 15;73(2):e6-7. § corresponding authors
D'Addario C§, Di Francesco A, Pucci M, Finazzi Agrò A, Maccarrone M§. Epigenetic mechanisms and endocannabinoid signalling. FEBS J. 2013 May; 280(9):1905-17. § corresponding author
Di Francesco A, Arosio B, Gussago C, Dainese E, Mari D, D'Addario C§, Maccarrone M*. J Alzheimers Dis. 2013;37(1):3-8. Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation. § corresponding authors
Pucci M, Rapino C, Di Francesco A, Dainese E, D'Addario C§, Maccarrone M§. Epigenetic control of skin differentiation genes by phytocannabinoids. Br J Pharmacol. 2013 Oct;170(3):581-91. § corresponding authors
Caputi FF, Di Benedetto M, Carretta D, Bastias del Carmen Candia S, D'Addario C, Cavina C, Candeletti S, Romualdi P. Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:36-46.
Bastías-Candia S, Di Benedetto M, D'Addario C, Candeletti S, Romualdi P. Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease. Environ Toxicol. 2013 Dec 23. doi: 10.1002/tox.21943.
D' Addario C§, Di Francesco A, Trabace L, Finazzi Agro' A, Cuomo V, Maccarrone M§. Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2 Suppl):61-73. § corresponding authors
Arosio B*, D'Addario C*, Gussago C, Casati M, Tedone E, Ferri E, Nicolini P, Rossi PD, Maccarrone M, Mari D. Peripheral blood mononuclear cells as alaboratory to study dementia in the elderly. Biomed Res Int. 2014;2014:169203. * equal contribution
Dell'Osso B*§, D'Addario C*§, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Di Francesco A, Maccarrone M, Altamura AC. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014 Sep;166:330-3. * equal contribution § corresponding authors
D'Addario C§, Micioni Di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M§. Endocannabinoid signaling and food addiction. Neurosci Biobehav Rev. 2014 Aug 27;47C:203-224. § corresponding authors
Di Francesco A, Falconi A, Di Germanio C, Micioni Di Bonaventura MV, Costa A, Caramuta S, Del Carlo M, Compagnone D, Dainese E, Cifani C, Maccarrone M, D'Addario C§. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J Nutr Biochem. 2015 Mar;26(3):250-8. § corresponding authors
Di Francesco A, Arosio B, Falconi A, Micioni Di Bonaventura MV, Karimi M, Mari D, Casati M, Maccarrone M, D'Addario C§. Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells. Brain Behav Immun. 2015 Mar;45:139-44. § corresponding authors
Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P. Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015 Oct 1;155:68-75.
Cifani C, Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Di Francesco A, Maccarrone M, D'Addario C§. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? Front Neurosci. 2015 Jun 8;9:187. § corresponding authors
Mancino S, Burokas A, Gutiérrez-Cuesta J, Gutiérrez-Martos M, Martín-García E, Pucci M, Falconi A, D'Addario C, Maccarrone M, Maldonado R. Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior. Neuropsychopharmacology. 2015 May 6. doi: 10.1038/npp.2015.129.
Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D'Addario C§. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addict Biol. 2016, 21(6):1168-1185. § corresponding authors
Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P.Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015; 155: 68-75.
Pucci M, D'Addario C§. Assessing Gene Expression of the Endocannabinoid System. Methods Mol Biol. 2016;1412:237-46. § corresponding authors
Ferri E, Arosio B, D'Addario C, Galimberti D, Gussago C, Pucci M, Casati M, Fenoglio C, Abbate C, Rossi PD, Scarpini E, Maccarrone M, Mari D. Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. J Neurol Sci. 2016 Mar 15;362:283-6.
Catanzaro G, Pucci M, Viscomi MT, Lanuti M, Feole M, Angeletti S, Grasselli G, Mandolesi G, Bari M, Centonze D, D'Addario C§, Maccarrone M. Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis. J Neuroimmunol. 2016 May 15;294:32-40. § corresponding authors
Zoratto F, Romano E, Pascale E, Pucci M, Falconi A, Dell'Osso B, Maccarrone M, Laviola G, D'Addario C, Adriani W. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. Neuroscience. 2017 Jan 6;340:101-116.
D'Addario C§, Shchetynsky K, Pucci M, Cifani C, Gunnar A, Vukojević V, Padyukov L, Terenius L. Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Mar 21;76:195-203. § corresponding author
Adriani W, Romano E, Pucci M, Pascale E, Cerniglia L, Cimino S, Tambelli R, Curatolo P, Granstrem O, Maccarrone M, Laviola G, D'Addario C. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. Eur Child Adolesc Psychiatry. 2018 Feb;27(2):241-252.
D'Addario C§, Micale V, Di Bartolomeo M, Stark T, Pucci M, Sulcova A, Palazzo M, Babinska Z, Cremaschi L, Drago F, Carlo Altamura A, Maccarrone M, Dell'Osso B. A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia. Schizophr Res. 2017 Jan 17. pii: S0920-9964(17)30031-2. § corresponding author
D'Addario C§, Candia SB, Arosio B, Di Bartolomeo M, Abbate C, Casè A, Candeletti S, Romualdi P, Damanti S, Maccarrone M, Bergamaschini L, Mari D. Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer's disease, a case report. J Neurol Sci. 2017 Jan 15;372:211-216. doi: 10.1016/j.jns.2016.11.052. § corresponding author
Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, D'Addario C§, Pautassi RM. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. § corresponding author
D'Addario C§, Palazzo MC, Benatti B, Grancini B, Pucci M, Di Francesco A, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Altamura AC, Maccarrone M, Dell'Osso B. Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:314-321. § corresponding author
Cimino S, Cerniglia L, Ballarotto G, Marzilli E, Pascale E, D'Addario C, Adriani W, Tambelli R. DNA Methylation at the DAT Promoter and Risk for Psychopathology: Intergenerational Transmission between School-Age Youths and Their Parents in a Community Sample. Front Psychiatry. 2018 Jan 10;8:303.
Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia. Neuropharmacology. 2019 Mar 1;146:212-221.
Pucci M, Micioni Di Bonaventura MV, Wille-Bille A, Fernández MS, Maccarrone M, Pautassi RM, Cifani C, D'Addario C§. Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. Neurosci Biobehav Rev. 2018 Jul 11. pii: S0149-7634(18)30108-8.
Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, D'Addario C§, Pautassi RM. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88.
Pucci M, Micioni Di Bonaventura MV, Zaplatic E, Bellia F, Maccarrone M, Cifani C, D'Addario C§. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. Int J Eat Disord. 2018 Dec 22. doi: 10.1002/eat.22989.
Wille-Bille A, Bellia F, Jiménez García AM, Miranda-Morales RS, D'Addario C§, Pautassi RM. Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake. Neuropharmacology. 2020 Mar 15;165:107917.
Fernández MS, Bellia F, Ferreyra A, Chiner F, Jiménez García AM, D'Addario C§, Pautassi RM. Short-term selection for high and low ethanol intake during adolescence exerts lingering effects in stress-induced ethanol drinking and yields an anxiety-prone phenotype. Behav Brain Res. 2020 Feb 17;380:112445.
Ginés I, Gil-Cardoso K, D'Addario C, Falconi A, Bellia F, Blay MT, Terra X, Ardévol A, Pinent M, Beltrán-Debón R. Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats. Biomolecules. 2019 Dec 12;9(12). pii: E865
Falconi A, Bonito-Oliva A, Di Bartolomeo M, Massimini M, Fattapposta F, Locuratolo N, Dainese E, Pascale E, Fisone G, D'Addario C§. On the Role of Adenosine A2A Receptor Gene Transcriptional Regulation in Parkinson's Disease. Front Neurosci. 2019 Jul 10;13:683
Cimino S, Cerniglia L, Ballarotto G, Marzilli E, Pascale E, D'Addario C, Adriani W, Maremmani AGI, Tambelli R. Children's DAT1 Polymorphism Moderates the Relationship Between Parents' Psychological Profiles, Children's DAT Methylation, and Their Emotional/Behavioral Functioning in a Normative Sample. Int J Environ Res Public Health. 2019 Jul 18;16(14). pii: E2567.
Dufrusine B, Di Francesco A, Oddi S, Scipioni L, Angelucci CB, D'Addario C, Serafini M, Häfner AK, Steinhilber D, Maccarrone M, Dainese E. Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation. Front Immunol. 2019 Jun 28;10:1347. doi: 10.3389/fimmu.2019.01347. eCollection 2019.
Pucci M, Micioni Di Bonaventura MV, Vezzoli V, Zaplatic E, Massimini M, Mai S, Sartorio A, Scacchi M, Persani L, Maccarrone M, Cifani C, D'Addario C§. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Front Genet. 2019 Jun 14;10:523.
Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C§, Cifani C. Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. J Psychopharmacol. 2019 Dec;33(12):1550-1561.
D'Addario C§, Bellia F, Benatti B, Grancini B, Vismara M, Pucci M, De Carlo V, Viganò C, Galimberti D, Fenoglio C, Scarpini E, Maccarrone M, Dell'Osso B. Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder. J Psychiatr Res. 2019 Jul;114:17-23.
Nassan M, Veldic M, Winham S, Frye MA, Larrabee B, Colby C, Biernacka J, Bellia F, Pucci M, Terenius L, Vukojevic V, D'Addario C§. Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder. J Affect Disord. 2020 Apr 15;267:96-102.
Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C, Dell'Osso B, Pariante CM, Perretti M, D'Acquisto F. Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Brain Behav Immun. 2020 Feb 29:S0889-1591(19)31560-0.
D'Addario C§, Zaplatic E, Giunti E, Pucci M, Micioni Di Bonaventura MV, Scherma M, Dainese E, Maccarrone M, Nilsson IA, Cifani C, Fadda P. Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa. Int J Eat Disord. 2020 Apr 10. doi: 10.1002/eat.23271.
Vismara M, Cirnigliaro G, Piccoli E, Giorgetti F, Molteni L, Cremaschi L, Fumagalli GG, D'addario C, Dell'Osso B. Crossing Borders Between Frontotemporal Dementia and Psychiatric Disorders: An Updated Overview. J Alzheimers Dis. 2020 Apr 16. doi: 10.3233/JAD-191333.
Lambacher G, Pascale E, Pucci M, Mangiapelo S, D'Addario C, Adriani W. Search for an epigenetic biomarker in ADHD diagnosis, based on the DAT1 gene 5'-UTR methylation: a new possible approach. Psychiatry Res. 2020;291:113154.
Tonelli E, Pascale E, Troianiello M, D'Addario C, Adriani W. DAT1 Gene Methylation as an Epigenetic Biomarker in Attention Deficit Hyperactivity Disorder: A Commentary. Front Genet. 2020;11:444. doi: 10.3389/fgene.2020.00444.
Bellia F, Fernández MS, Fabio MC, Pucci M, Pautassi RM, D'Addario C§. Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence. Drug Alcohol Depend. 2020;212:108025.
Sabatucci A, Berchet V, Bellia F, Maccarrone M, Dainese E, D'Addario C§, Pucci M. A new methodological approach for in vitro determination of the role of DNA methylation on transcription factor binding using AlphaScreen® analysis: Focus on CREB1 binding at hBDNF promoter IV. J Neurosci Methods. 2020;341:108720.
Rubino A, D'Addario C, Di Bartolomeo M, Michele Salamone E, Locuratolo N, Fattapposta F, Vanacore N, Pascale E. DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients. Acta Neurol Scand. 2020. doi: 10.1111/ane.13279.
Stark T, Di Bartolomeo M, Di Marco R, Drazanova E, Platania CBM, Iannotti FA, Ruda-Kucerova J, D'Addario C, Kratka L, Pekarik V, Piscitelli F, Babinska Z, Fedotova J, Giurdanella G, Salomone S, Sulcova A, Bucolo C, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. Biochem Pharmacol. 2020;177:114004.
§ corresponding author
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Capitoli Libri
Pucci, M., D'Addario, C. Assessing Gene Expression of the Endocannabinoid System. Methods Mol Biol. (2016) 1412:237-46.
D’Addario, C., Maccarrone, M., Alcohol and epigenetic modulations. Molecular Aspects of Alcohol and Nutrition. A Volume in the Molecular Nutrition Series (2016) Chapter 21. ISBN: 978-0-12-800773-0
D’Addario, C L’epigenetica. I radicali liberi e la loro rilevanza in biomedicine (2016). Appendice B
D’Addario C, Pucci M. Basi di epigenetica: focus sullo studio della metilazione del DNA gene-specifica. Metodologie Biochimiche e Biomolecolari. Zanichelli, 2019.
Elenco partecipazione a Congressi nazionali ed internazionali ultimi 10 anni
Alcohol consumption during pregnancy induces altered transcriptional regulation in mothers and offspring partially counteracted by environment enrichment. 17th ESBRA – European Society for Biomedical Research on Alcoholism. September 21-24, 2019 – Lille, France.
On the role of DNA methylation and hydroxymethylation in Obsessive Compulsive Disorder: focus on BDNF.32nd ECNP Congress. September 7-10, 2019 – Copenaghen, Denmark.
DI PSICOPATOLOGIA, 21-24/02/2018, Roma, Italy. INVITED SPEAKER
Università degli Studi di Teramo Campus "Aurelio Saliceti" via R. Balzarini 1 64100 Teramo tel. 0861.2661 P.I. 00898930672 - C.F. 92012890676
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