Prof. PESERICO Alessia
Prof. PESERICO Alessia

Email: apeserico@unite.it

Telefono: -

Facoltà di appartenenza: BIOSCIENZE E TECNOLOGIE AGRO-ALIMENTARI E AMBIENTALI


 
 
 
 

Curriculum accademico

 

Alessia Peserico è RTD-A presso la Facoltà Di Bioscienze e Tecnologie Agro-Alimentari ed Ambientali dell’Università degli Studi di Teramo. Ha conseguito la laurea in Biotecnologie Genomiche presso l’Università Sapienza (Roma) ed ha completato la sua formazione accademica conseguendo il titolo di PhD in Life and Biomolecular Sciences presso la Open University (Regno Unito). L’attività di ricerca è finalizzata alla comprensione dei meccanismi molecolari coinvolti nel signalling intracellulare in contesti fisiologici (follicologenesi ovarica e cellule staminali epiteliali amniotiche) e patologici (tumori).

Le prime attività di ricerca, riconosciute e sostenute a livello nazionale dall’Associazione Italiana per la Ricerca sul Cancro (AIRC) sono state finalizzate allo studio dell’epigenetica dei tumori del colon-retto, ovaio e mammella, con particolare interesse per le modifiche istoniche associate alla acquisizione del fenotipo maligno (ruolo della metiltransferasi istonica SMYD3).  Le sue ricerche sono state inoltre dedicate allo studio di fattori molecolari con ruolo chiave nelle alterazioni metaboliche proprie delle cellule tumorali (AMPK/FoxO3A). Ad oggi, il suo interesse di ricerca si concentra principalmente nel campo della follicologenesi ovarica e dei meccanismi alla base della transizione epitelio-mesenchimale in cellule staminali epiteliali amniotiche in modelli pre-clinici per la loro applicazione nel campo della medicina rigenerativa. Tali studi prevedono l’utilizzo di sistemi colturali 2D e 3D (scaffolds e sferoidi).

Le suddette attività sono state svolte in collaborazione con diversi enti accademici e di ricerca: Università di Teramo, Università di Bari, Open University (UK), IRCCS Saverio De Bellis (Castellana Grotte), IRCCS Istituto Tumori Bari Giovanni Paolo II (Bari), Centro di ricerche farmacologiche e biomediche Mario Negri Sud (Chieti), IZSAM G. Caporale (Teramo).

Complessivamente le ricerche svolte si sono concretizzate in un brevetto e in 16 pubblicazioni su riviste scientifiche internazionali. Di seguito gli indici bibliometrici di riferimento: Numero di citazioni: 553; h-index: 10; IF medio: 5,5 (Scopus). Revisore per la rivista internazionale FEBS Open Bio e membro delle seguenti associazioni:

EACR (European Association of Cancer Research)

ESHRE (European Society of Human Reproduction and Embriology).

Curriculum english version

 

Alessia Peserico is currently a RTD-A in the Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo.  She is a graduate of Sapienza University in Rome, Italy (Bachelor’s degree) and Open University in UK (PhD). Her research primarily focuses on cellular and molecular mechanisms driving physiological processes such as ovarian folliculogenesis and immunomodulatory properties of the amniotic epithelial stem cells. Also, her interests have been focused on pathways related to tumorigenesis.

Her original research, founded by the AIRC association (Italian Association of Cancer Research), aimed to understand the epigenetic events (SMYD3 methyltransferase) driving tumor formation and progression and to investigate transcriptional mechanisms regulating tumor metabolism (AMPK/FoxO3A) in colorectal, ovarian and breast cancer models. She is currently working on gaining understanding on the signalling network orchestrating in vitro and in vivo ovarian folliculogenesis by means of 2D and 3D culture models for pre-clinical studies. Also, she is focused on the comprehension of the amniotic epithelial stem cells mechanisms tuning immune-modulation, crucial for the development of for innovative, cell-based regenerative medicine solutions.

The above mentioned activities have been carried out in collaboration with different research and academic institutions: University of Teramo, University of Bari, Open University (UK), IRCCS Saverio De Bellis (Castellana Grotte), IRCCS Istituto Tumori Bari Giovanni Paolo II (Bari), Mario Negri Sud Foundation(Chieti), National Reference Centre for Whole Genome Sequencing of microbial pathogens at the IZSAM G.Caporale (Italy).

She has published 16 papers in international journals and she has authored one patent. Bibliometrics parameters are: total citations = 553; h-index = 10; average IF = 5,5 (from Scopus). She is invited reviewer for FEBS Open Bio international journal and she is member of the EARC (European Association of cancer Research) and ESHRE (European Society of Human Reproduction and Embriology) societies.

Pubblicazioni

 

Greco L, Russo V, Rapino C, et al. Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response. Cells. 2020;9(4):1008. Published 2020 Apr 18. doi:10.3390/cells9041008.

 

Bottino C, Peserico A, Simone C, Caretti G. SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways. Cancers (Basel). 2020;12(1):142. Published 2020 Jan 6. doi:10.3390/cancers12010142.

 

Ianni A, Di Domenico M, Bennato F, et al. Metagenomic and volatile profiles of ripened cheese obtained from dairy ewes fed a dietary hemp seed supplementation. J Dairy Sci. 2020;103(7):5882-5892. doi:10.3168/jds.2019-17954.

 

Peserico A, Marcacci M, Malatesta D, Di Domenico M, Pratelli A, Mangone I, D'Alterio N, Pizzurro F, Cirone F, Zaccaria G, Cammà C, Lorusso A. Diagnosis and characterization of canine distemper virus through sequencing by MinION nanopore technology. Sci Rep. 2019 Feb 8;9(1):1714. doi: 10.1038/s41598-018-37497-4. PMID: 30737428; PMCID: PMC6368598.

 

Beato MS, Marcacci M, Schiavon E, Bertocchi L, Di Domenico M, Peserico A, Mion M, Zaccaria G, Cavicchio L, Mangone I, Soranzo E, Patavino C, Cammà C, Lorusso A. Identification and genetic characterization of bovine enterovirus by combination of two next generation sequencing platforms. J Virol Methods. 2018 Oct; 260:21-25.

 

Grossi V, Forte G, Sanese P, Peserico A, Tezil T, Lepore Signorile M, Fasano C, Lovaglio R, Bagnulo R, Loconte D, Susca F, Resta N, Simone C.The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. Nucleic Acid Research. 2018 Jun 20;46(11):5587-5600.

 

Celestini V, Tezil T, Russo L, Fasano C, Sanese P, Forte G, Peserico A, Lepore Signorile M, Longo G, De Rasmo D, Signorile A, Gadaleta RM, Scialpi N, Terao M, Garattini E, Cocco T, Villani G, Moschetta A, Grossi V, Simone C.Uncoupling FoxO3A mitochondrial end nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis. 2018 Feb 14.

 

Ranieri C, Di Tommaso S, Loconte DC, et al. In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS). Neurogenetics. 2018;19(2):77-91. doi:10.1007/s10048-018-0540-1.

 

Grossi V, Lucarelli G, Forte G, Peserico A, Germani A, Rutigliano M, Matrone A, Stella A, Bagnulo R, Loconte D, Galleggiante V, Sanguedolce F, Cagiano S, Bufo P, Trabucco S, Maiorano E, Ditonno P, Battaglia M, Resta N, Simone C. Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38α. Autophagy. 2015 Nov 2;11(11):2102-2113.

 

Peserico A, Germani A, Sanese P, Barbosa AJ, Di Virgilio V, Fittipaldi R, Fabini E, Bertucci C, Varchi G, Moyer MP, Caretti G, Del Rio A, and Simone C. A SMYD3 Small- molecule inhibitor impairing cancer cell growth. Journal of Cellular Physiology. 2015 Oct;230(10):2447-60.

 

Germani A, Matrone A, Grossi V, Peserico A, Sanese P, Liuzzi M, Palermo R, Murzilli S, Campese AF, Ingravallo G, Canettieri G, Tezil T, Simone C. Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. Cancer Letters. 2014 Mar 1;344(1):110-8.

 

Grossi V, Peserico A, Tezil T and Simone C. The p38alpha MAPK pathway: a key factor in colorectal cancer therapy and chemoresistence. World Journal of Gastroenterology.2014. Aug 7;20(29):9744-58.

 

Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LWS, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cellular And Molecular Life Sciences. 2013 Jun;70(11):2015-29.

 

Madia F, Grossi V, Peserico A, Simone C. Updates from the intestinal front line: autophagic weapons against inflammation and cancer. Cells. 2012 Aug 21;1(3):535-57.

 

Chiacchiera F, Grossi V, Cappellari M, Peserico A, Simonatto M, Germani A, Russo S, Moyer MP, Resta N, Murzilli S, Simone C. Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. Cancer Letters. 2012 Nov 1;324(1):98-108.

 

Peserico A and Simone C. 2011. Physical and Functional HAT/HDAC interplay regulates protein acetylation balance. Journal of Biomedicine and Biotechnology. 2011;2011:371832.

 

Prodotti della ricerca

 

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Ultimo aggiornamento: 10-06-2019
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