Università degli studi di Teramo

Sei in: Docente

 
Prof. LOI Pasqualino
Prof. LOI Pasqualino
Email: ploi@unite.it

Telefono: 0861-266856

Facoltà di appartenenza: MEDICINA VETERINARIA

Dipartimento:
 
 
 

Curriculum accademico

 

Nato a Pozzomaggiore, SS, Sardegna, il 15 Ottobre 1958,
sposato con Grazyna Ptak, con due figli, Cristina e Pietro Loi.
1980-86- Laurea in Medicina Veterinaria presso l'Università di Sassari con 110 e lode 
Studi Post-Universitari: 1987-1990, Università di Sassari, Istituto di Fisiologia Veterinaria, dottorato di ricerca in Fisiologia della riproduzione 
Posizioni Post-dottorali: 
1990-1991, sperimentatore presso l'Istituto Zootecnico e Caseario (SS)
1992-1994, stage presso il Roslin Institute, Scozia, UK, nel laboratorio dei Profs. Ian Wilmut and Keith Campbell.
1994 -settembre 1995: studi sull'analisi dell'espressione genica mediante la tecnica dell'ibridazione in situ presso l'University of Newcastle upon-tyne, nell'ambito di un corso organizzato dall'EMBO (European Molecular Biology Organization) 
1995-November 2000, coordinatore del laboratorio di biotecnologie dell'Istituto Zootecnico e Caseario (SS).
Dal novembre 2000 professore associato di Fisiologia presso la facoltà di Medicina Veterinaria di Teramo.
La principale linea di ricerca del Prof. Loi è la Fisiologia della Riproduzione, in particolare l'embriologia sperimentale applicata ai ruminanti domestici e selvatici. Il Prof. Loi è membro delle seguenti società: Società delle Scienze Veterinarie, Società dei Fisiologi Italiani, Society for the Study of Fertility, International Embryo Transfer Society,
Society for the Study of Reproduction. La sua linea di ricerca attuale sono i meccanismi di riprogrammazione nucleare di cellule somatiche. 

Incarichi presso Istituzioni di Ricerca Europee/Internazionali:

Vice presidente della sessione Fisiologia della European Association for Animal Production, 1998-2001.

Membro dell'Advisory Board del Centro di Eccellenza "Center of Excellence in Genomic and Biotechnology for Improving Functional Traits in Farm Animals and Theirs Products" dell'Accademia delle Scienze Polacca, (VI programma quadro dalla Comunità Europea).

Membro dell'Advisory Board Centre of Excellence Europeo ANIMBIOGEN - 2009-2012, VII Programma Quadro della EU

Referee (expert list) del VI programma EU

Referee per la l'European Science Foundation (EFS).

Referee della European Research Council (ERC), valutatore dei progetti di ricerca 
del programma IDEAS del VII programma EU.

Referee del programma Marie Curie del VII programma EU.

Referee per l'United States -Israel Binational Science Foundation (BSF)

Membro del Managing Commette del programma EU COST - Gemini, VII programma Quadro - 2008-2011.

Editorial board delle riviste:
Cellular Reprogramming. ISSN: 2152-4971
Animal Science Papers and Reports. ISSN 0860-4037.

Ad hoc referee per seguenti riviste Scientifiche Internazionali:
Biology of Reproduction, Reproduction, Theriogenology, Gene,Trends in Biotechnology Cloning and Stem Cells, Reproduction Fertility and Development, Reproduction in Domestic animals, Genomics, PLoS ONE.

Il Prof. Loi ha coordinato/partecipato come PI (Principal Investigator) a progetti di ricerca finanziati dal MIUR (PRIN e FIRB), Europei, European Science Foundation (ESF) e del VI e VII programma Quadro della EU ed Internazionali United States Deparment of Agriculture (USDA).

Il prof. Loi è autore di oltre 180 lavori scientifici - 74 con peer review - (quasi tutti in collaborazione con prestigiosi Istituzioni di ricerca internazionali).

Curriculum english version

 
Name: Pasqualino 
Surname: Loi
Born: Sardina (Italy), 15.10.1958
Status: married with Grazyna Ptak, two children, Cristina e Pietro Loi.

a. Professional Preparation

1980-1986- DVM Veterinary Medicine, Sassari University (Italy) 
1987-1990, PhD Reproductive Physiology, Sassari University (Italy) 
1990-1991, Post Doc in experimental embryology, Institute for Zootechnics, Olmedo, Sassari, Italy 
1992-1994, Post Doctoral Fellow Roslin Institute, UK 
September 1995 - EMBO Fellow, University of Newcastle Upon-Tyne, UK,


b. Appointments
1995-October 2000, research scientist, Institute for Zootechnics, Olmedo, Sassari, Italy
November 2000 - Present: Associate Professor in Animal Physiology, University of Teramo (Italy)

My main Scientific interest has always been Developmental Biology and particularly all aspects of Biotechnologies applicable on embryos; in vitro maturation and fertilization, in vitro embryo culture, embryo freezing, embryo biopsy and sexing by PCR, embryonic manipulation with special regard to nuclear transfer (cloning). My current area of research is nuclear reprogramming and the epigenetic modification of DNA induced on early embryos by cloning and other in vitro manipulations.

c. Professional Service: Ad hoc reviewer: Biology of Reproduction, Theriogenology, Gene, Trends in Biotechnology, Cloning and Stem Cells, Theriogenology, Reproduction, Fertility and Development, Gene, Genomics, Reproduction in Domestic Animals, PLoS ONE.

Vice President of the Physiology Commission at the European Association for Animal Production from 1999-2002; Advisory Board Member of the European Centre of Excellence founded by the VI FP EU in Genomic and Biotechnology for Improving Functional Traits in Farm Animals and Theirs Products" , Polish Academy of Sciences, Warsaw. 
Member of Board of governors of the centre of excellence "Animibiogen" VII FP EU, Polish Academy of Sciences, Warsaw.
Expert evaluator for the VI and VII EU FrameWork Programmes.
Expert evaluator for the European Science Foundation,
Expert evaluator for the European Research Council (ERC) - remote evaluation.
Expert Evaluator for the Marie Curie programme of the VII EUFramework.
Expert evaluator for the United States -Israel Binational Science Foundation (BSF)
Expert Evaluator for the Polish Academy of Sciences
Expert Evaluator for the Cyprus National Research Council

Editorial Board member of:
Cellular Reprogramming. Mary Ann Liebert inc. ISSN: 2152-4971
Animal Science Papers and Reports" Member of the Managing Committee for the COST action - Gemini (VII FP), and Epiconcept (VII FP)

I have a robust experience in coordinating and participating in Research Projects, both a national level (PRIN, INTERLINK, FIRB) and at international level (Royal Society, British Council, European Science Foundation - ESF - United States Department of Agriculture - USDA; European Research Council - ERC; COST programme). I have published several relevant papers in my field of expertise, nuclear transfer. I have organized many national and international meeting, and I am particularly active in networking with foreign Research Institution. I have published over 80 papers on peer reviewed journals, including excellence ones, like PNAS and Nature Biotechnology.

Pubblicazioni

 
Loi P, Czernik M, Zacchini F, Iuso D, Scapolo PA, Ptak G (in stampa). Sheep: The First Large Animal Model in Nuclear Transfer Research. CELLULAR REPROGRAMMING, ISSN: 2152-4971

S Sampino, G R Juszczak, F Zacchini, A H Swiergiel, J A Modlinski, P Loi, G E Ptak (2014). Grand-paternal age and the development of autism-like symptoms in mice progeny. TRANSLATIONAL PSYCHIATRY, vol. 4, ISSN: 2158-3188, doi: 10.1038/tp.2014.27

Iuso D, Czernik M, Zacchini F, Ptak G, Loi P (2013). A simplified approach for oocyte enucleation in mammalian cloning.. CELLULAR REPROGRAMMING, vol. 15, ISSN: 2152-4971, doi: 10.1089/cell.2013.0051

Czernik M, Fidanza A, Sardi M, Galli C, Brunetti D, Malatesta D, Della Salda L, Matsukawa K, Ptak G, Loi P (2013). Differentiation potential and GFP labeling of sheep bone marrow derived mesenchymal stem cells.. JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 114, p. 134-143, ISSN: 0730-2312, doi: 10.1002/jcb.24310.


Ptak GE, Modlinski JA, Loi P (2013). Embryonic diapause in humans: time to consider?. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 11, ISSN: 1477-7827, doi: 10.1186/1477-7827-11-92



Iuso D, Czernik M, Di Egidio F, Sampino S, Zacchini F, Bochenek M, Smorag Z, Modlinski JA, Ptak G, Loi P (2013). Genomic stability of lyophilized sheep somatic cells before and after nuclear transfer. PLOS ONE, vol. Epub 2013 Jan 8., p. 1-10, ISSN: 1932-6203, doi: 10.1371/journal.pone.0051317


Iuso D, Czernik M, Di Egidio F, Sampino S, Zacchini F, Bochenek M, Smorag Z, Modlinski JA, Ptak G, Loi P (2013). Genomic stability of lyophilized sheep somatic cells before and after nuclear transfer.. PLOS ONE, vol. 8, ISSN: 1932-6203, doi: 10.1371/journal.pone.0051317



Ptak GE, D'Agostino A, Toschi P, Fidanza A, Zacchini F, Czernik M, Monaco F, Loi P (2013). Post-implantation mortality of in vitro produced embryos is associated with DNA methyltransferase 1 dysfunction in sheep placenta. HUMAN REPRODUCTION, vol. 28, p. 298-305, ISSN: 0268-1161, doi: 10.1093/humrep/des397



Ptak GE, D'Agostino A, Toschi P, Fidanza A, Zacchini F, Czernik M, Monaco F, Loi P (2013). Post-implantation mortality of in vitro produced embryos is associated with DNA methyltransferase 1 dysfunction in sheep placenta.. HUMAN REPRODUCTION, vol. 28, ISSN: 0268-1161, doi: 10.1093/humrep/des397



Ptak G, D'Agostino Antonella, Toschi Paola, Fidanza Antonella, Zacchini Federica, Marta Czernik, Monaco Federica, Loi Pasqualino (2013). Postimplantational mortality of in vitro produced embryos is associated with DNA methyltransferase 1 (DNMT1) dysfunction in placenta.. HUMAN REPRODUCTION, ISSN: 0268-1161, doi: 10.1093/humrep/des397

allegati


Loi P, Czernik M, Zacchini F, Iuso D, Scapolo PA, Ptak G (2013). Sheep: the first large animal model in nuclear transfer research.. CELLULAR REPROGRAMMING, vol. 15, ISSN: 2152-4971, doi: 10.1089/cell.2013.0032



Loi P., Czernik M., Zacchini F., Iuso D., Scapolo P.A., Ptak G. (2013). Sheep: the first large model in nuclear transfer research. HUMAN REPRODUCTION, vol. 15, p. 367-373, ISSN: 0268-1161, doi: 10.1089/cell.2013.0032



Fulka J Jr, Langerova A, Loi P, Ptak G, Albertini D, Fulka H (2013). The ups and downs of somatic cell nucleus transfer (SCNT) in humans.. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol. 30, ISSN: 1058-0468, doi: 10.1007/s10815-013-0053-7



Ptak G, Zacchini F, Czernik M, Fidanza A, Palmieri C, Della Salda L, Scapolo PA, Loi P (2012). A short exposure to polychlorinated biphenyls deregulates cellular autophagy in mammalian blastocyst in vitro.. HUMAN REPRODUCTION, vol. 27, p. 1034-1042, ISSN: 0268-1161, doi: 10.1093/humrep/der454

allegati


Ptak G, Tacconi E, Czernik M, Toschi P, Modlinski JA, Loi P (2012). Embryonic diapause is conserved across mammals.. PLOS ONE, vol. 7, p. 1-7, ISSN: 1932-6203, doi: 10.1186/1477-7827-11-92



Loi P, Teruhiko Wakayama, Josef Fulka Jr and Grazyna Ptak. (2011). Biological time machines: a realistic approach for cloning an extinct mammal.. ENDANGERED SPECIES RESEARCH, vol. 14, p. 227-233, ISSN: 1613-4796

Zacchini F, Czernik M, Iuso D, Toschi P, di Egidio F, Scapolo P.A., Loi P, Ptak G (2011). Efficient Production and Cellular Characterization of Sheep Androgenetic Embryos. CELLULAR REPROGRAMMING, vol. Dec;13(6), p. 495-502, ISSN: 2152-4971, doi: 10.1089/cell.2011.0021

Loi P, Fulka J Jr, Hildebrand T, Ptak G (2011). Genome of non-living cells: trash or recycle?. REPRODUCTION, vol. 76, p. 217-228, ISSN: 1470-1626

Loi P, Modlinski JA, Ptak G (2011). Interspecies somatic cell nuclear transfer: a salvage tool seeking first aid.. THERIOGENOLOGY, vol. 76, p. 217-228, ISSN: 0093-691X

Fulka J Jr, Langerova A, Loi P, Martinkova S, Fulka H. (2011). Transplantation of nucleoli into human zygotes: not as simple as expected? . JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol. 28(5), p. 385, ISSN: 1058-0468

FULKA JR J, LOI P, PTAK G, FULKA H, JOHN JS (2009). Hope for the Mammoth?. CLONING AND STEM CELLS, ISSN: 1536-2302



LOI P, BEAUJEAN N, KHOCHBIN S, FULKA J JR, PTAK G (2008). Asymmetric nuclear reprogramming in somatic cell nuclear transfer?. BIOESSAYS, vol. 30, p. 66-74, ISSN: 0265-9247



LOI P, GALLI C, PTAK G (2008). Cloning of endangered mammalian species: any progress?. TRENDS IN BIOTECHNOLOGY, vol. 25, p. 195-200, ISSN: 0167-7799



FULKA J JR, FULKA H, ST JOHN J, GALLI C, LAZZARI G, LAGUTINA I, FULKA J, LOI P (2008). Cybrid human embryos--warranting opportunities to augment embryonic stem cell research. TRENDS IN BIOTECHNOLOGY, vol. 26, p. 469-474, ISSN: 0167-7799



LOI P, MATSUKAWA K, PTAK G, CLINTON M, FULKA J JR, NATHAN Y, ARAV A (2008). Freeze-dried somatic cells direct embryonic development after nuclear transfer. PLOS ONE, vol. e2978., ISSN: 1932-6203



TURCO MY, MATSUKAWA K, CZERNIK M, GASPERI V, BATTISTA N, DELLA SALDA L, SCAPOLO P.A., LOI P, MACCARRONE M, PTAK G. HUMAN REPROD. OCT, - (2008). High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation. HUMAN REPRODUCTION, vol. 23, p. 2331-2338, ISSN: 0268-1161, doi: 10.1093/humrep/den258



Loi P, Matsukawa K, Takahashi S, Akagi S, Ptak G (2008). Nuclear reprogramming: what has been done and potential avenues for improvements. CENTRAL EUROPEAN JOURNAL OF BIOLOGY, vol. 3, p. 211-223, ISSN: 1895-104X



LOI P, MATZUKAWA K, PTAK G, NATAN Y, FULKA J JR, ARAV A (2008). Nuclear transfer of freeze-dried somatic cells into enucleated sheep oocytes. REPRODUCTION IN DOMESTIC ANIMALS, vol. 43, p. 417-422, ISSN: 0936-6768



PALMIERI C, LOI P, PTAK G, DELLA SALDA L (2008). Review paper: a review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice. VETERINARY PATHOLOGY, vol. 45, p. 865-880, ISSN: 0300-9858


LOI P, GALLI C, PTAK G (2007). Cloning of endangered mammalian species: any progress?. TRENDS IN BIOTECHNOLOGY, vol. 25, p. 195-200, ISSN: 0167-7799

Matsukawa K, Turco MY, Scapolo PA, Reynolds L, Ptak G, Loi P (2007). Development of sheep androgenetic embryos is boosted following transfer of male pronuclei into androgenetic hemizygotes. . CLONING AND STEM CELLS, vol. 9, p. 374-381, ISSN: 1536-2302, doi: 10.1089/clo.2006.0016

PALMIERI C, LOI P, REYNOLDS LP, PTAK G, DELLA SALDA (2007). Placental abnormalities in ovine somatic cell clones at term: a light and electron microscopic investigation. PLACENTA, vol. 28, p. 577-584, ISSN: 0143-4004, doi: 10.1016/j.placenta.2006.08.003

PTAK G, MATSUKAWA K, PALMIERI C, DELLA SALDA L, SCAPOLO PA, LOI P (2006). Developmental and functional evidence of nuclear immaturity in prepubertal oocytes. HUMAN REPRODUCTION, vol. 21 (9), p. 2228-2237, ISSN: 0268-1161, doi: 10.1093/humrep/del184



PTAK G, LOPES F., MATSUKAWA K., TISCHNER M., LOI P. (2006). Leukaemia inhibitory factor enhances sheep fertilization in vitro via an influence on the oocyte. THERIOGENOLOGY, vol. 65, p. 1891-1899, ISSN: 0093-691X




GRAZYNA PTAK, LOI P, FEDERICA LOPES, KAZUTSUGU MATSUKAWA, MARIAN TISCHNER, PASQUALINO LOI (2006). Leukemia Inhibitory Factor enhances sheep ferilization in vitro via an influence on the oocyte. THERIOGENOLOGY, p. 1-10, ISSN: 0093-691X



LOI P., CLINTON M., VACKOVA I., FULKA JR., J., FEIL R., PALMIERI, DELLA SALDA L., PTAK G (2006). Placental abnormalities associated with post-natal mortality in sheep somatic cell clones. THERIOGENOLOGY, vol. 65, p. 1110-1121, ISSN: 0093-691X, doi: 10.1016/j.theriogenology.2005.07.016



PASQUALINO LOI, MICHAEL CLINTON, IRENA VACKOVA, JOSEF FULKA JR, ROBERT FEIL, CHIARA PALMIERI, LEONARDO DELLA SALDA, PTAK G (2006). Placental abnormalities associated with post-natal mortality in sheep somatic cell clones. THERIOGENOLOGY, vol. 65, p. 1110-1121, ISSN: 0093-691X, doi: 10.1016/j.theriogenology.2005.07.016



IRENA VACKOVA, RADOMIR KREN, PASQUALINO LOI, VLADIMR KRYLOV AND JOSEF FULKA, LOI P (2006). The absence of DNA replication checkpoint in porcine zygotes. ZYGOTE, vol. 14, p. 33-37, ISSN: 0967-1994




FULKA J JR, MRAZEK M, FULKA H, LOI P (2005). Mammalian oocyte therapies. CLONING AND STEM CELLS, vol. 7, p. 183-188, ISSN: 1536-2302



LOI P (2004). Are there realistic opportunities to apply cloning and the other reproductive biotechnologies for safeguarding endangered species?. ANIMAL SCIENCE PAPERS AND REPORTS, vol. 22, p. 81-89, ISSN: 0860-4037



FULKA J JR, LOI P, FULKA H, PTAK G, NAGAI T. (2004). Nucleus transfer in mammals: noninvasive approaches for the preparation of cytoplasts. TRENDS IN BIOTECHNOLOGY, vol. 22, p. 279-283, ISSN: 0167-7799




Mattioli M, Gioia L, Turriani M, Capacchietti G, Loi P, Ptak G (2004). Oocyte maturation is required for correct sperm chromatin rearrangement. VETERINARY RESEARCH COMMUNICATIONS, vol. 28 (1), p. 205-208, ISSN: 0165-7380



LOI P., DELLA SALDA L, PTAK G (2004). Peri- and post-natal mortality of somatic cell clones in sheep. ANIMAL SCIENCE PAPERS AND REPORTS, vol. 22, suppl. 1, p. 59-70, ISSN: 0860-4037



BEAUJEAN N, TAYLOR JE, MCGARRY M, GARDNER JO, WILMUT I, LOI P, PTAK G, GALLI C, LAZZARI G, BIRD A, YOUNG LE, MEEHAN RR (2004). The effect of interspecific oocytes on demethylation of sperm DNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 20, p. 7636-7640, ISSN: 1091-6490



LOI P, FULKA J JR, PTAK G (2003). Amphibian and mammal somatic-cell cloning: different species, common results? (Cover page). TRENDS IN BIOTECHNOLOGY, vol. 21, p. 471-473, ISSN: 0167-7799


MATTIOLI M, BARBONI B, GIOIA L, LOI P (2003). Cold-induced calcium elevation triggers DNA fragmentation in immature pig oocytes. MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 65(3), p. 289-297, ISSN: 1040-452X, doi: 10.1002/mrd.10275

YOUNG LE, SCHNIEKE AE, MCCREATH KJ, WIECKOWSKI S, KONFORTOVA G, FERNANDES K, PTAK G, KIND AJ, WILMUT I, LOI P, FEIL R. (2003). Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer. MECHANISMS OF DEVELOPMENT, vol. 120, p. 1433-1442, ISSN: 0925-4773

PTAK GRAZYNA, TISCHENR MARIAN, BERNABÒ NICOLA, LOI P (2003). Donor-Dependent Developmental Competence of Oocytes from Lambs Subjected to Repeated Hormonal Stimulation. BIOLOGY OF REPRODUCTION, vol. 69 (1), p. 278-285, ISSN: 0006-3363

FULKA J, MOOR RM, LOI P, FULKA J (2003). Enucleolation of porcine oocytes. THERIOGENOLOGY, vol. 59, p. 1879-1885, ISSN: 0093-691X

FULKA J JR, LOI P, FULKA H, KREN R, DEAN W, MRAZEK M, REIK W (2003). Nucleus replacement in Mammalian oocytes. CLONING AND STEM CELLS, vol. 4, p. 181-187, ISSN: 1536-2302

LOI P, BARBONI B, PTAK G (2002). Cloning advances and challenges for conservation. TRENDS IN BIOTECHNOLOGY, vol. 20, p. 233, ISSN: 0167-7799, doi: 10.1016/S0167-7799(02)01955-8
PTAK G., CLINTON M., TISCHNER M., BARBONI B., MATTIOLI M, LOI P. (2002). Improving delivery and offspring viability of in vitro-produced and cloned sheep embryos. BIOLOGY OF REPRODUCTION, vol. 67(6), p. 1719-1725, ISSN: 0006-3363, doi: 10.1095/biolreprod66.3.796

PLOI P, CLINTON M., BARBONI B., FULKA J. JR., CAPPAI P., FEIL R., MOOR R.H.M., PTAK G. (2002). Nuclei of nonviable ovine somatic cells develop into lambs after nuclear transplantation.. BIOLOGY OF REPRODUCTION, vol. 67, p. 126-132, ISSN: 0006-3363, doi: 10.1095/biolreprod67.1.126

PTAK G., CLINTON M., BARBONI B., MUZZEDDU M., CAPPAI P., TISCHNER M., LOI P (2002). Preservation of the wild European mouflon: the first example of genetic management using a complete program of reproductive biotechnologies. BIOLOGY OF REPRODUCTION, vol. 66, p. 796-801, ISSN: 0006-3363, doi: 10.1095/biolreprod66.3.796

LOI P, PTAK G, BARBONI BARBARA, FULKA JOSEF JR, CAPPAI PIETRO, MICHAEL CLINTON (2001). Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells. NATURE BIOTECHNOLOGY, vol. 19, p. 962-964, ISSN: 1087-0156

FULKA J. JR, LOI P, LEDDA S, MOOR RHM, FULKA J (2001). Nucleus transfer in mammals: how the oocyte cytoplasm modifies the transferred nucleus. THERIOGENOLOGY, vol. 55, p. 1373-1380, ISSN: 0093-691X

J. FULKA JR, J. TESARIK, LOI P, R.M. MOOR (2000). Manipulating the Human embryo: Cell Cycle Checkpoint Controls. CLONING AND STEM CELLS, vol. 2, p. 1-7, ISSN: 1536-2302

FULKA J JR, TESARÍK J, LOI P, MOOR RM (2000). Manipulating the human embryo: cell cycle checkpoint controls. CLONING AND STEM CELLS, vol. 2, p. 1-7, ISSN: 1536-2302

PLOI P, FULKA J.JR., NAITANA S., CAPPAI P. (1999). Cloning by nuclear transfer: experiences in sheep. LIVESTOCK PRODUCTION SCIENCE, vol. 60, p. 281-294, ISSN: 0301-6226

PTAK G, LOI P., DATTENA M., TISCHNER M., CAPPAI P. (1999). Offspring from one-month-old lambs: studies on the developmental capability of prepubertal oocytes. BIOLOGY OF REPRODUCTION, vol. 61, p. 1568-1574, ISSN: 0006-3363


PTAK G., DATTENA M., LOI P, TISCHNER M., CAPPAI P (1999). Ovum pick-up in sheep: efficiency of in vitro embryo production, vitrification and offspring. THERIOGENOLOGY, vol. 52, p. 1105-1114, ISSN: 0093-691X

LOI P, PTAK G., DATTENA M., LEDDA S., NAITANA S., CAPPAI P (1998). 26.Embryo transfer and related technologies in sheep reproduction. REPRODUCTION NUTRITION DEVELOPMENT, vol. 38, p. 615-628, ISSN: 0926-5287

FULKA J. JR. FIRST N. L., LOI P, MOOR R. M (1998). Cloning by somatic cell nuclear transfer. BIOESSAYS, vol. 20, p. 847-851, ISSN: 0265-9247

LOI P, LEDDA S., FULKA J.JR., CAPPAI P., MOOR R.M. (1998). Development of parthenogenetic and cloned ovine embryos: effect of activation protocols. BIOLOGY OF REPRODUCTION, vol. 58, p. 1177-1187, ISSN: 0006-3363

FEIL R, KOSHLA S, CAPPAI P, LOI P (1998). Genomic imprinting in ruminants: allele-specific gene expression in parthenogenetic sheep. MAMMALIAN GENOME, vol. 9, p. 831-834, ISSN: 0938-8990


NAITANA S., LEDDA S., LEONI G., BOGLIOLO L., LOI P, CAPPAI P (1998). Membrane integrity and fertilizing potential of cryopreserved spermatozoa in European mouflon. ANIMAL REPRODUCTION SCIENCE, vol. 52, p. 105-112, ISSN: 0378-4320



LEDDA S, BOGLIOLO L, LEONI G, LOI P, CAPPAI P, NAITANA S (1998). Two culture systems showing a biphasic effect on ovine embryo development from the 1-2 cell stage to hatched blastocysts. REPRODUCTION NUTRITION DEVELOPMENT, vol. 35, p. 629-637, ISSN: 0926-5287


CAMPBELL K.H.S., LOI P, OTAEGUI P., WILMUT I (1997). Cell cycle co-ordination in embryo cloning by nuclear transfer. JOURNAL OF REPRODUCTION AND FERTILITY, vol. 1, p. 40-46, ISSN: 0022-4251

LOI P, BOYAZOGLU S., GALLUS M., BRANCA A., LEDDA S., NAITANA S., WILMUT I., CAPPAI P (1997). Embryo Cloning in Sheep: work in progress. THERIOGENOLOGY, vol. 48, p. 1-10, ISSN: 0093-691X
NAITANA S, LEDDA S, LOI P, LEONI G, BOGLIOLO L, DATTENA M, CAPPAI P (1997). Polyvinyl alcohol as a defined substitute for serum in vitrification and warming solutions to cryopreserve ovine embryos at different stages of development. ANIMAL REPRODUCTION SCIENCE, vol. 48, p. 247-256, ISSN: 0378-4320

CAMPBELL KH, LOI P, OTAEGUI PJ, WILMUT I (1996). Cell cycle co-ordination in embryo cloning by nuclear transfer. REVIEWS OF REPRODUCTION, vol. 1, p. 40-46, ISSN: 1359-6004

NAITANA S, LOI P, LEDDA S, CAPPAI P, DATTENA M, BOGLIOLO L, LEONI G (1996). Effect of biopsy and vitrification on in vitro survival of ovine embryos at different stages of development. THERIOGENOLOGY, vol. 46, p. 813-824, ISSN: 0093-691X

LEDDA S., LOI P, BOGLIOLO L., MOOR R.M. FULKA J. JR. (1996). The effect of 6- Dimethylaminopurine (6-DMAP) on DNA synthesis in activated mammalian oocytes. ZYGOTE, vol. 4, p. 7-9, ISSN: 0967-1994

CAMPBELL K.H.S., LOI P, CAPPAI P., WILMUT I (1994). Improved development to blastocyst of ovine nuclear transfer embryos reconstructed during the presumptive S-Phase of enucleated-activated oocytes. BIOLOGY OF REPRODUCTION, vol. 50, p. 1385-1393, ISSN: 0006-3363

Prodotti della ricerca

 

Projects coordination


  1. Coordinator - FIRB (stands for: Founds for Excellence in Basic Research), founded by the Italian Minister of University - MIUR - 2001-3, Grant (RBNE01HPMX) "Identification of the molecular mechanism regulating the expression of genes and transgenes affecting productive traits for the safe and efficient application of embryo technologies to farm animals", 2.5 million Euro
  1. Coordinator PRIN FIRB, CNR project: GenHome. Genomic resort addressing embryo.maternal interaction: 6 million euro in tota
  2. Coordinator - PRIN (stands for: Project of National Relevance founded by the Italian Minister of the University - MIUR) 2001-3. Differentiative plasticity of adult and embryonic stem cells"219.100Euro

  1. PI - PRIN MIUR 2003-2005 (2003073943_002). "Impact of different environmental contaminants on sheep reproductive efficiency: characterization of the mechanisms involved and of possible interactions". 97.700Euro

  1. Coordinator - PRIN MIUR 2004-2006 "Development of sheep preclinical model for testing efficiency and safety of Cell Therapy (through "Therapeutic cloning"), 78.000 euro.

  1. PI - European Science Foundation grant "Stellar" 2004-007 "Novel approaches to enhance animal embryonic stem cell and nuclear reprogramming research" acronym; EUROCORES Programme EuroSTELLS, supported by funds from the European Commission Sixth Framework Programme under contract no. ERAS-CT-2003-980409; 154000 euros

  1. PI - United States Department of Agriculture (USDA)"Proposal#2007-01215 "Deregulation of Placenta vascular development in ART-derived sheep foetuses-" 350.000 $

  1. Coordinator - University of Teramo grant, former 60%. 2003-2008 "Nuclear functionality in prepubertal lamb oocytes" 28000 euros.

Coordination of Internalization grants and programs for scientific exchanges.
  1. participant, member of the managing committee: Cost Action "Epiconcept", 2012-2017
  2. Coordinator, Cultural and scientific exchange programme of Italian Foreign Affair 2002-2005 between the University of Teramo and the Institute of Animal Production, Prague (Czech Republic) "Biotechnological approaches for the preservation of endangered species" (jointly with Dr. Josef Fulka Jr, Prague).
  3. Participant, British Council/MIUR/ CRUI, 2003-4 "Inducing Cell Plasticity by Epigenetic Reprogramming ex Ovo" - partner; jointly with DR. Lorraine Young, Nottingham University and Dr. Michael Clinton, former Roslin Institute, UK.
  4. Project leader (jointly with Dr. Robert Feil (Then working at Babrham Institute, Cambridge UK), Studies on imprinted gene expression in parthenogenetic sheep foetuses" founded by the Royal Society (UK) 1999-2000.
  5. Coordinator, MIUR, programme Interlink (II04C0H723) 2006-2009. "Epigenetic maturation of prepubertal sheep oocytes", jointly with, Prof. Niemann (Mariensee, Germany)
  6. Local responsible (for Teramo University) for the Programme"Cost Action FA0702 - Gemini, Maternal Interactions with Gametes and Embryos" 7FP.
  7. Participant, British Society/Miur-Crui, 2005-2006 exchange programme, "Epigenetic effects on environmental contaminants on sheep embryos", jointly with Dr. Michael Clinton, former Roslin Institute, UK.

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