Call for application: 3 ESR for P4FIT project

 P4FIT
P4FIT

P4 FIT call will open on 19.02.2021
The deadline for applications by 31.03.2021

 

Info: p4fit@unite.it

 

To apply to P4 FIT call:

  1. Please go to: https://segreteriaonline.unite.it;
  2. Choose in the Menu the English language (en);
  3. Registration: follow the instructions;
  4. Once registered, "Login";
  5. Choose in the Menu "Registrar’s Office";
  6. In the Registrar’s Office choose "Admission test"
  7. Proceed with your application by following;
  8. Download and fill "Application form".
 

ESR profiles details

ESR1 - Stem cell-based immune modulation and regeneration

 

Objectives: To study in depth how amniotic membrane cells and how the bioactive factors can foster tissue resolution by dampening proinflammatory signals (cytokines and cells), thus enhancing anti-inflammatory immune components and contributing to the fabrication of innovative nanovectors (NVs) to develop immune targeting strategies for tendon regeneration.

 

Expected Results: 

  1. Small scale production of immune-modulatory secretomes collected from amniotic derived stem cells/membranes.
  2. In vitro immune-modulatory testing of different secretomes on culture of human macrophages.
  3. Identification of intracellular signalling-mediating immune mechanism.
  4. Molecular characterization of stem cell-derived secretomes.
  5. Identification of storage methods for preserving the immune-influence of secretomes.
  6. Fabrication of NVs enriched with secretomes or their derivates.
  7. Spatio-temporal pharmacokinetics of secretome-derived NV.
  8. In vitro immune-modulatory testing of NV on culture of human macrophage.

Keywords: nanomedicines, immunology, nanoparticles, tendon regeneration, amniotic derived stem cells, secretome.

 

Applicant Profile: Master level in biology, biomedical biotechnology, medicine, veterinary medicine or related field, ideally with background in eukaryote cell biology and biotechnology, immunology, biomedical engineering, biochemistry or tissue engineering. Excellent communication skills (both written and oral) in English.

 

PhD main locations: The recruited ESR is given the opportunity to conduct 3-years of PhD studies at Faculty of Bioscience, Agri-Food and Environmental Technology, University of Teramo (UNITE, Italy) and at Faculty of Pharmacy, University of Helsinki (UH, Finland), and secondments at Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (Italy), and at Biouniversa s.r.l. (Italy),

 

Double PhD Tutors: Prof. B. Barboni and Prof. E. Dainese (Doctoral Programme in Cellular and Molecular Biotechnologies, UNITE) and Prof. H. A. Santos (Doctoral Programme in Drug Research, UH).

 

 

ESR 5- Innovation applied to veterinary regenerative medicine

 

Objectives: To move preclinical proof-of-concepts related to tendon healing effectiveness and safety of different stem cells source or cell-free nanomedicine approaches towards to veterinary clinic.

 

Expected Results: 

  1. In vivo experimental studies of early, middle and long-term tendon healing impact on sheep animal models of different stem cells source (autologous transplantation of adipose derived cells vs. xenotransplantation of amniotic derived cells).
  2. In vivo experimental studies of early tendon healing impact on animal models of functionalized nanodevices with immunomodulatory bioactive molecules alone or in combination with stem cells.
  3. Morphological, biomechanical and biochemistry advanced analysis of stem cells/nanodrug delivery influence on tendon regeneration.
  4. Translation of the results to clinic levels by developing multi-centric trials on spontaneous horses SDFT sub-acute tendinopathies.
  5. Test the wireless biosensors for the prognosis of tendon diseases in horses to improve personalized rehabilitation and clinical outcomes.

Keywords: tendon, tendon regeneration, stem cells, amniotic derived stem cells, nanomedicines, immunology, regenerative medicine.

 

Applicant Profile: Master level in biology, biomedical biotechnology, veterinary medicine, medicine or related
field, ideally with background in eukaryote cell biology and biotechnology, immunology, biochemistry, or tissue
engineering. Excellent communication skills (both written and oral) in English.

 

PhD main locations: The recruited ESR is given the opportunity to conduct 3-years of PhD studies at Faculty of Bioscience, Agri-Food and Environmental Technology, University of Teramo (UNITE, Italy) and at Medical University of Vienna (MUW, Austria), and secondments at Fat-Stem Laboratories BV (Belgium).

 

Double PhD Tutors: Prof. P. Berardinelli and Prof. L. Valbonetti (Doctoral Programme in Cellular and Molecular Biotechnologies, UNITE); Prof. J. Stöckl (Doctoral Programme in Immunology, MUW).

 

 

ESR13 - Personalized diagnosis for orienting tendon clinics

 

Objectives: To identify and characterize in vivo models for the protein profiles during spontaneous vs. stem cell/nanodrug delivery systems-treated tendon healing involving healthy and metabolically diseased/aged animals, and to compare the expression of the potential biomarkers with the profile obtained in microdialysis collected from patients and with patient-reported clinical outcome.
Expected Results:

  1. Experimental model of tendon defect on metabolic diseased mice undergoing spontaneous or amniotic epithelial stem cells or nanodrug delivery systems induced healing to characterize the profiles of neuronal mediators, growth factors and inflammatory molecules.
  2. Characterize the proteomic profiles of ex vivo tissues.
  3. Correlate the tissue profiles with the movement and vital data of the housed mice in the DVC Digi-Lab cages.
  4. Compare the expression of the potential biomarkers in tendon explants collected from experimental animals and human healthy, and metabolically diseased/aged tendon explants.
  5. Compare the tissue identified biomarkers profile with the profile obtained in microdialysis collected from patients and with patient-reported clinical outcome. Test nanobiosensors to detect the prognostic biomarkers finalized for medical health.

Keywords: nanomedicines, nanoparticles, biomedical engineering, tendon, tendon regeneration, tendon biomarkers, stem cells, amniotic epithelial stem cells.


Applicant Profile: Master level in biology, biomedical biotechnology, medicine, veterinary medicine or related field, ideally with background in eukaryote cell biology and biotechnology, immunology, biochemistry or tissue engineering. Excellent communication skills (both written and oral) in English.


PhD main locations: The recruited ESR is given the opportunity to conduct 3-years of PhD studies at Faculty of Bioscience, Agri-Food and Environmental Technology, University of Teramo (UNITE, Italy) and at Faculty of Pharmacy, University of Helsinki (UH, Finland), and secondments at Department. of Molecular Medicine and Surgery, Karolinska Institutet (KI, Sweden), at Consiglio Nazionale delle Riceche (CNR-EMMA, Italy), and Tecniplast (Italy).


Double PhD Tutors: Prof. B. Barboni, Prof. V. Russo, and Prof. L. Valbonetti (Doctoral Programme in Cellular and Molecular Biotechnologies, UNITE); Prof. H. A. Santos (Doctoral Programme in Drug Research, UH).

 

 
 
 

 
Ultimo aggiornamento: 03-06-2021
Seguici su