Esperienza professionale

2025

Abilitazione Scientifica Nazionale a Professore di Prima Fascia (03/CHEM-07 CHIMICA FARMACEUTICA, TOSSICOLOGICA, NUTRACEUTICO-ALIMENTARE, DELLE FERMENTAZIONI E DEI PRODOTTI PER IL BENESSERE E PER LA SALUTE)

2025  

Dipartimento di Bioscienze e Tecnologie Agro-Alimentari e Ambientali, Università degli Studi di Teramo – Teramo, Italia
Professore Associato (Chimica biologica)

2022 - 2025

Dipartimento di Bioscienze e Tecnologie Agro-Alimentari e Ambientali, Università degli Studi di Teramo – Teramo, Italia
RTDB (Chimica biologica)

06/2022 – 11/2022
Visiting Professor nel programma internazionale “Tomás de Iriarte”; Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna – Tenerife, Spagna

06/2021 – 05/2022
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma – Italia
Be-For-ERC international fellowship
Progetto: SulPhenOx

01/2021 – 03/2021
Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna – Tenerife, Spagna
Borsa di studio FEBS

06/2020 – 05/2021
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma – Italia
Assegno di Ricerca
Titolo del progetto: Purificazione di composti bioattivi naturali mediante approccio di chimica verde

01/2020 – 04/2020
Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna – Tenerife, Spagna
Borsa di studio EMBO

12/2018 – 12/2019
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma – Italia
Assegno di Ricerca
Titolo del progetto: Chimica e attività biologica di composti organici naturali e metaboliti contenenti zolfo in modelli cellulari di neurodegenerazione

11/2017 – 11/2018
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry – Halle (Saale), Germania
Post-doctoral international Fellowship Leibniz-DAAD
Titolo del progetto: "Metabolomics-based Elucidation of the Bioactive Principles of Endemic Cuban Medicinal Plants"

02/2017 – 11/2017
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma e "GNOSIS" S.p.A.
Progetto di ricerca post-dottorato: Analisi dei derivati tioesteri del glutatione e determinazione della S-Adenosilmetionina nel plasma umano

01/2016 – 01/2017
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma – Italia
Borsa post-dottorato (Progetto FILAS)
Progetto: Studi chimici e biologici sul β-esaclorocicloesano, inquinante ambientale persistente della Valle del Sacco (Italia)

11/2015 – 11/2017
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Università di Roma – Italia
Tutor di esercitazioni di biochimica per studenti delle scuole superiori
Progetto "Bioform 2015-2017" (Fondazione per l'Avanzamento della Ricerca in Medicina Molecolare - ONLUS)

03/2015 – 09/2015
Facultad de Biología, Departamento de Biología Vegetal, Universidad de La Habana – Cuba
Visiting scientist: Studi di genotossicità e mutagenicità del 2,4,6-triidrossifenantrene prodotto dalla foto-ossidazione del trans-resveratrolo; Estrazione e caratterizzazione di sostanze organiche naturali derivanti da flora endemica tropicale cubana

11/2012 – 11/2015
Sapienza Università di Roma – Italia
Tutor di Biochimica presso il Dipartimento di Scienze Biochimiche

10/2010 – 10/2012
Azienda farmaceutica "NOOS" S.r.l. – Italia
Consulente per lo sviluppo di antiossidanti e prodotti naturali

 

 

Formazione

a.a. 2014/2015
Dottorato di Ricerca in Chimica Biologica, Sapienza Università di Roma

a.a. 2011/2012
Laurea Magistrale in Biotecnologie Farmaceutiche, Sapienza Università di Roma
Votazione: 110/110 con lode

 

Premi e finanziamenti ricevuti

1. Progetto di ricerca PNRR– NextGenerationEU. Progetto COMETA (Studio della risposta a condizioni di stress ambientali e da caldo mediante scienze omiche - Metabolomica, Epigenomica e Trascrittomica - negli animali da reddito), Anno 2024. Responsabile scientifico (PI) per l’Università degli Studi di Teramo – 220.000 €
2. Programma “Maria Zambrano” per il Talento Internazionale nella Ricerca 2022, Ministero della Scienza e dell'Innovazione, Spagna
3. Borsa internazionale “Tomas de Iriarte” 2022 per Professore Visitante, Università di La Laguna, Spagna (15.000 €)
4. Borsa di ricerca Be-For ERC 2021, Università “Sapienza” di Roma, Italia (50.000 €)
5. Borsa della Federazione delle Società Biochimiche Europee (FEBS) 2021 (5.700 €)
6. Riconoscimento "Seal of Excellence" 2020: Marie Skłodowska-Curie actions (MSCA) nell'ambito di Horizon 2020
7. Borsa di ricerca dell'Organizzazione Europea di Biologia Molecolare (EMBO) 2019 (6.000 €)
8. Finanziamento Sapienza Ateneo Starting Grant 2019 – 2020 – 2021, Università “Sapienza” di Roma, Italia (2.000 € ciascuno)
9. Borsa di ricerca Leibniz-DAAD 2017-2018: Università di Halle, Germania (24.000 €)
10. Borsa di ricerca FILAS 2016, Regione Lazio, Italia (19.000 €)
11. Premio per la “Miglior presentazione di poster” al Simposio di Dottorato BeMM (Biology and Molecular Medicine) 2015, Università “Sapienza” di Roma, Italia
12. Finanziamento Sapienza Ateneo Starting Grant 2015, Università “Sapienza” di Roma, Italia (2.000 €)
13. Finanziamento Sapienza Ateneo Starting Grant 2014, Università “Sapienza” di Roma, Italia (2.000 €)
14. Premio “Laureato Eccellente” 2013 conferito dal Rettore dell’Università “Sapienza” di Roma, Italia
15. Borsa di studio 2012, Università “Sapienza” di Roma. Facoltà di Farmacia e Medicina (1.095 €)
16. Borsa di studio 2011, Università “Sapienza” di Roma. Ente per il diritto allo studio Laziodisu (4.400 €)
17. Borsa di studio 2010, Università “Sapienza” di Roma. Ente per il diritto allo studio Laziodisu (4.400 €)
18. Borsa di studio 2009, Università “Sapienza” di Roma. Museo di Anatomia Patologica (1.095 €)
19. Borsa biblioteca 2008, Università “Sapienza” di Roma, Biblioteca di Scienze Biochimiche “A. Rossi Fanelli” (1.095 €)
20. Borsa di studio 2007, Università “Sapienza” di Roma. Ente per il diritto allo studio Laziodisu (4.400 €)

Brevetti

• Extracts in eutectic solvent of olive oil polyphenols, compositions, uses and methods of preparation thereof    
  WO WO2023218391A1.
  Richiedente: Active-Italia S.R.L. Roma (IT)
  Inventori: Federico R., Mosca L., Mattioli R., Francioso A., Miceli E., Berti U.
  Priorità: 11-05-2022 • Deposito: 11-05-2023 • Pubblicazione: 16-11-2023
• Stabilizzazione in soluzione e dopo irraggiamento del trans-resveratrolo e altri polifenoli mediante l’utilizzo di solventi eutettici
  N. IT 102021000025259.
  Richiedente: Noos S.r.l., Roma (IT)
  Inventori: Moretti G., Mosca L., Federico R., Francioso A.
  Priorità: 01-10-2021 • Deposito: 01-10-2021 • Concessione: 22-07-2023
• Metodo per la preparazione di olio di oliva con caratteristiche qualitative, sensoriali e nutrizionali determinate
  N. IT 102023000006075.
  Richiedente: Active-Italia S.R.L. Roma (IT)
  Inventori: Federico R., Mosca L., Francioso A., Mattioli R.
  Priorità: 29-03-2023 • Deposito: 29-03-2023
• Protezione dalla degradazione dell’RNA mediante l’utilizzo di solventi eutettici
  N. IT 102023000009447.
  Richiedente: Active-Italia S.R.L. Roma (IT)
  Inventori: Federico R., Mosca L., Mattioli R., Maggiore A., Francioso A., Miceli E., Berti U.
  Priorità: 11-05-2023 • Deposito: 11-05-2023

 

Partecipazione a progetti di ricerca

1. Progetto di ricerca con l’azienda NOOS srl, Anno 2011, “Messa a punto di un metodo di determinazione cromatografica del resveratrolo applicato all’analisi del prodotto linfovir” – 10.000 €
2. Progetto di ricerca con l’azienda NOOS srl, Anno 2012, “Messa a punto di nuove formulazioni di uno spray nasale a base di Resveratrolo” – 12.000 €
3. Progetto di ricerca con l’azienda NOOS srl, Anno 2013, “Messa a punto di una nuova formulazione in aerosol a base di Resveratrolo” – 18.000 €
4. Estrazione di prodotti naturali dalla flora tropicale cubana (L’Avana, Cuba 2015, Prof. Sanchez-Lamar)
5. Progetto di ricerca con l’azienda GNOSIS spa, Anno 2016, “Messa a punto di metodi cromatografici per la determinazione di S-AdenosilMetionina e Glutatione/S-AcetilGlutatione in plasma mediante cromatografia RP-HPLC e applicazione in studi di farmacocinetica” – 50.000 €
6. Contratto con GNOSIS spa, Anno 2017, “Determinazione della S-adenosilmetionina in campioni di plasma umano e di ratto mediante RP-HPLC” – 40.000 €
7. Progetto con GNOSIS spa, Anno 2017, “Determinazione della S-adenosilmetionina in campioni di plasma di ratto mediante RP-HPLC” – 22.000 €
8. Contratto con NOOS srl, Anno 2018, “Studio dell’attività proteolitica di una miscela di probiotici sulla gliadina e sul peptide 33-Mer” – 17.500 €
9. Progetto di ricerca con GNOSIS spa, Anno 2018, “Assorbimento di una formulazione di SAMe fitato da parte di un monostrato di cellule CaCo-2” – 7.500 €

Affiliazioni a società scientifiche e attività editoriale

1. Phytochemical Society of Europe (PSE)
2. Società Italiana di Biochimica (SIB)
3. Società Chimica Italiana (SCI)
4. Mediterranean Neuroscience Society (MNS)
5. Editor tematico della rivista scientifica Separations (MDPI); curatore del numero speciale “Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds”
6. Guest editor per la rivista Molecules (MDPI); curatore del numero speciale “Resveratrol News & Views: From the Molecular Mechanism to Nutritional and Biomedical Applications”
7. Guest editor del numero speciale “The Search for Antimicrobial Agents from Natural Products” per la rivista Antibiotics
8. Topic editor for the scientific journal Frontiers in Pharmacology. Editor for the Special issue “Phytochemistry and Ethnopharmacology of Natural Bioactive Products against Inflammation and Neurodegeneration”

Attività didattica

1. Membro del Collegio dei Docenti del Dottorato di Ricerca in "Biotecnologie Molecolari e Cellulari", Dipartimento di Bioscienze e Tecnologie Agro-Alimentari e Ambientali, Università di Teramo
2. Membro della Commissione Assicurazione Qualità del Corso di Laurea in Biotecnologie, Università di Teramo
3. Docente titolare del corso “Biochimica Strutturale e Funzionale” (6 CFU), CdL in Biotecnologie, a.a. 2022/2023 e successivi, Università di Teramo
4. Docente titolare del corso “Biomarker Molecolari per la valorizzazione delle produzioni sostenibili” (6 CFU), CdL in Intensificazione sostenibile delle produzioni ortofrutticole di qualità, a.a. 2022/2023 e successivi, Università di Teramo
5. Referente e coordinatore dell accordo Quadro internazionale tra Università di Teramo e Universidad de La Habana (CUBA)
6. Abilitazione Scientifica Nazionale a Professore di Prima Fascia (03/D1 - CHIMICA E TECNOLOGIE FARMACEUTICHE, TOSSICOLOGICHE E NUTRACEUTICO- ALIMENTARI), bando 2023/2025
7. Abilitazione Scientifica Nazionale a Professore di Seconda Fascia (SC:05/E1– BIOCHIMICA GENERALE), bando 2021/2023
8. Cultore della materia e assistente didattico di Biochimica, 2021, Facoltà di Farmacia e Medicina, Università “Sapienza” di Roma
9. Docente di Chimica e Biologia, Liceo Scientifico, Roma, 2019
10. Docente di Scienze, Liceo Scientifico, Roma, 2018
11. Lezioni di: “Biochimica analitica degli inquinanti ambientali”, Università “Sapienza” di Roma, 2017
12. Progetto “Bioform” – Attività pratiche di biochimica e biologia molecolare per studenti delle scuole superiori, Roma, 2015–2017 (Fondazione per l’Avanzamento della Ricerca in Medicina Molecolare – ONLUS)
13. Attività didattica nei laboratori di Biochimica, 2012–2015, Facoltà di Farmacia e Medicina, Dipartimento di Scienze Biochimiche, Università “Sapienza” di Roma

 

ATTIVITA DI RICERCA E INTERESSI SCIENTIFICI:

Antonio Francioso ha focalizzato la sua attività di ricerca sulla chimica e biochimica delle sostanze organiche naturali biologicamente attive. Ha studiato in dettaglio le proprietà fotochimiche dello stilbene naturale bioattivo trans-resveratrolo, identificando per la prima volta il prodotto di fotoconversione 2,4,6-triidrossifenantrene. In collaborazione con l’Università dell’Avana (Cuba), ha successivamente valutato il potenziale genotossico di questo fotoprodotto.

Nel corso dei suoi studi, ha collaborato allo sviluppo una nuova formulazione di resveratrolo in associazione a carbossimetil β-D-glucano, migliorandone la stabilità e valutandone l’attività antivirale. Questa ricerca, condotta in collaborazione ha conivolto aziende farmaceutiche e altri gruppi di ricerca e ha portato al deposito di un brevetto e alla pubblicazione di numerosi articoli scientifici su riviste internazionali di rilievo.

Nel 2017-2018, grazie a una borsa post-dottorato Leibniz-DAAD, ha lavorato presso il Leibniz Institute of Plant Biochemistry in Germania, dove ha isolato e caratterizzato dalla pianta Phyllanthus orbicularis proveniente dalla flora tropicale endemica cubana una nuova sostanza naturale fenolica (3’,4’,5,7-tetrahydroxydihydroflavonol-8-C-β-D-glucopyranoside, Fideloside) dimostrandone il potenziale antinfiammatorio. Questa scoperta ha aperto nuove prospettive nello studio degli enzimi coinvolti nella biosintesi di C-glicosidi, composti rari con promettenti caratteristiche farmacologiche e particolari profili farmacocinetici. Qualche anno dopo il Prof. Francioso nell’ambito di un progetto di ricerca sulle sostanze naturali da flora tropicale e sub-tropicale ha isolato e elucidato la struttura chimica di un altro nuovo prodotto naturale (2″,4″,6″-6-C-triacetyl β-D-glucopyranosyl-(2S)-3′,4′,5,7- tetrahydroxyflavan-4-one, Tenelloside) dalle promettenti attività biologiche proveniente dalla pianta Phyllanthus tenellus Roxb. presente a Tenerife nell’arcipelago delle isole Canarie.

Il Prof. Francioso ha inoltre indagato i composti organici volatili secreti da formiche del genere Tapinoma, identificando sostanze iridoidi e chetoni coinvolti nella comunicazione chimica e difesa della specie. Ha caratterizzato il veleno della nuova specie Tapinoma darioi e sintetizzato alcuni dei principi bioattivi presenti nella frazione volatile.

Un'altra importante linea di ricerca portata avanti, si occupa dello studio dei secoiridoidi fenolici dell’olio d’oliva e delle sostanze naturali solforate, con l’obiettivo di identificare intermedi chiave nel metabolismo dello zolfo organico. Questo filone di ricerca nasce con lo scopo di elucidare le vie e gli intermedi chiave nel metabolismo dello zolfo al fine di colmare aspetti ancora poco chiari sulla biochimica di questo elemento fondamentale per numerose funzioni vitali.

Professional Experience

2025

National Scientific qualification as Full professor for the disciplinary field 03/CHEM-07 MEDICINAL, TOXICOLOGICAL, NUTRACEUTICAL-FOOD, FERMENTATION AND HEALTH AND WELLBEING PRODUCTS CHEMISTRY

2025

Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. Assiociate Professor of Biological Chemistry

2022 - 2025

Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. Assistant Professor of Biological Chemistry

06/2022 – 11/2022

Visiting Professor with the International program “Tomas de Iriarte”; Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain

06/2021 – 05/2022

Department of Biochemical Sciences "A. Rossi Fanelli" Sapienza University of Rome, Italy-International Be-for-ERC post-doctoral fellowship. Project acronym: SulPhenOx

01/2021 – to 03/2021

Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain – FEBS grant.

06/2020 – to 05/2021

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship. Title of the project: "Purification of natural bioactive compounds through a green chemistry approach"

01/2020 – 04/2020

Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain – EMBO grant.

12/2018 – 12/2019

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship. Title of the project: "Chemistry and biological activity of organic natural compounds and sulfur-containing metabolites in cellular models of neurodegeneration"

11/2017 – 11/2018

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB-Halle), Halle (Saale), Germany-Leibniz-DAAD post-doctoral fellowship. Title of the project: "Metabolomics-based Elucidation of the Bioactive Principles of Endemic Cuban Medicinal Plants"

02/2017 - 11/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, and "GNOSIS" S.p.a.- Post-doctoral research project: "Analytical investigations on glutathione thioester derivatives and determination of S-Adenosylmethionine in human plasma"

01/2016 – 01/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship (FILAS project): "Chemical and biological studies on β-hexachlorocyclohexane, a persistent environmental pollutant of Valle del Sacco (ITALY)"

11/2015-11/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Teaching assistant of molecular biology exercises for high school students in "Bioform project 2015-2017" (Foundation for the Advancement of Research in Molecular Medicine - ONLUS)

03/2015- 09/2015

Faculty of Biology, Department of Plant Biology, University of Havana, Cuba - Visiting scientist: Genotoxicity and mutagenicity of 2,4,6-trihydroxyphenantrene; Extraction and characterization of natural products from endemic tropical flora

11/2012- 11/2015

Sapienza University of Rome, Italy- Teaching assistant of Biochemistry at the Department of Biochemical Sciences

10/2010- 10/2012

Pharmaceutical company "NOOS" S.r.l.- Consultant for antioxidants and natural products development

 

Education

a.a. 2014/2015

PhD in Biological Chemistry, “Sapienza” University of Rome

a.a. 2011/2012

MSc in Pharmaceutical Biotechnology, “Sapienza” University of Rome

Results: 110 /110 cum laude

 

Prizes and Awards received.

 

- Research project PNRR– NextGenerationEU. Progetto COMETA "Studio della risposta a Condizioni di stress ambientali e da caldo mediante scienze Omiche - Metabolomica, Epigenomica e Trascrittomica - negli Animali da reddito" Year 2024. PI e responsabile scientifico per Università degli studi di Teramo 220.000 €

- “Maria Zambrano” International Talents 2022, University of La Laguna, Spain (Ministry of Science and Innovation, Government of Spain)

- “Tomas de Iriarte” Visiting Professor grant 2022, University of La Laguna, Spain

- Be-for ERC grant 2021, “Sapienza” University of Rome, Italy (€ 50000)

- Federation of European Biochemical Societies FEBS grant 2021 (€ 5700)

- Seal of Excellence 2020: Marie Skłodowska-Curie actions (MSCA) in Horizon 2020 (European Commission)

- European Molecular Biology Organization EMBO Research grant 2019 (€ 6000).

- Sapienza Ateneo Starting Grant 2019 – 2020 - 2021. “Sapienza” University of Rome, Italy (€ 2000 each)

- Leibniz-DAAD Research Fellowship 2017-18: University of Halle, Germany (€ 24000).

- FILAS research grant 2016. Regione Lazio, Italy (€ 19000)

- Best Poster presentation” award at BeMM (Biology and Molecular Medicine) PhD Symposium 2015 “Sapienza” University of Rome, Italy

- Sapienza Ateneo Starting Grant 2015. “Sapienza” University of Rome, Italy (€ 2000)

- Sapienza Ateneo Starting Grant 2014. “Sapienza” University of Rome, Italy (€ 2000)

- “Graduated Excellent” AWARD 2013 from the Dean of “Sapienza” University of Rome, Italy

- Scholarship 2012 “Sapienza” University of Rome. Faculty of Pharmacy and Medicine (€ 1095).

 

Participation to Research Projects.

1. Research project with the NOOS srl company, Year 2011, “Messa a punto di un metodo di determinazione cromatografica del resveratrolo applicato all’analisi del prodotto linfovir” 10000 €
2. Research project with the NOOS srl company, Year 2012, “Messa a punto di nuove formulazioni di uno spray nasale a base di Resveratrolo” 12000 €
3. Research project with the NOOS srl company, Year 2013, “Messa a punto di una nuova formulazione in aerosol a base di Resveratrolo” 18000 €
4. Extraction of Natural product from Cuban tropical flora, (La Havana, Cuba 2015, Prof. Sanchez-Lamar)
5. Research project with the company GNOSIS spa, Year 2016, “Messa a punto di metodi cromatografici di determinazione della S-AdenosilMetionina e del Glutatione/S-AcetilGlutatione in campioni di plasma mediante cromatografia ad elevata risoluzione in fase inversa (RP-HPLC) e loro utilizzo in studi di farmacocinetica” 50000 €
6. Contract with the company GNOSIS spa, Year 2017, “Determinazione della S-adenosilmetionina in campioni di plasma umano e di ratto mediante cromatografia ad elevata risoluzione in fase inversa (RP-HPLC)” 40000 €
7. Research project with the company GNOSIS spa, Year 2017, “Determinazione della S-adenosilmetionina in campioni di plasma di ratto mediante cromatografia ad elevata risoluzione in fase inversa (RP-HPLC)” 22000 €  
8. Contract with the company NOOS srl, Year 2018, “Studio dell’attività proteolitica di una miscela di probiotici sulla gliadina e sul peptide 33-Mer” 17500 €
9. Research project with the company GNOSIS spa, Year 2018, “Assorbimento di una formulazione di SAMe fitato da parte di un monostrato di cellule CaCo-2” 7500€

 

Patents

 

-  Extracts in eutectic solvent of olive oil polyphenols, compositions, uses and methods of preparation thereof WO WO2023218391A1. Applicant: Active-Italia S.R.L. Roma (IT) Inventors: Federico R., Mosca L., Mattioli, R., Francioso A., Miceli E., Berti U. Priority 2022-05-11 • Filed 2023-05-11 • Published 2023-11-16

- Stabilizzazione in soluzione e dopo irraggiamento del trans-resveratrolo e altri polifenoli mediante l'utilizzo di solventi eutettici, N. IT 102021000025259. Applicant: Noos S.r.l., Roma (IT) Inventors: Moretti G., Mosca L., Federico R., Francioso A. Priority 2021-10-01 • Filed 2021-10-01 • Granted 2023-22-07

- Metodo per la preparazione di olio di oliva con caratteristiche qualitative, sensoriali e nutrizionali determinate. N IT 102023000006075. Applicant Active-Italia S.R.L. Roma (IT) Inventors: Federico R, Mosca L, Francioso A, Mattioli R. Priority 2023-03-29 • Filed 2023-03-29

- Protezione dalla degradazione dell'RNA mediante l'utilizzo di solventi eutettici. N IT 102023000009447. Applicant Active-Italia S.R.L. Roma (IT) Inventors: Federico R., Mosca L., Mattioli, R., Maggiore A., Francioso A., Miceli E., Berti U. Priority 11-05-2023 • Filed 11-05-2023

 

Memberships of scientific societies and editorial activity

 

- Phytochemical Society of Europe (PSE)

- Member of the Italian Society of Biochemistry (SIB)

- Member of the Italian Society of Chemistry (SCI)

- Mediterranean Neuroscience Society (MNS)

- Topic editor for the scientific journal Seaparations MDPI. Editor for the Special issue “Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds”

- Guest editor for the scientific journal Molecules MDPI. Editor for the Special issue “Resveratrol News & Views: From the Molecular Mechanism to Nutritional and Biomedical Applications”

- Guest Editor of Special Issue "The Search for Antimicrobial Agents from Natural Products"

Journal: Antibiotic

- Topic editor for the scientific journal Frontiers in Pharmacology. Editor for the Special issue “Phytochemistry and Ethnopharmacology of Natural Bioactive Products against Inflammation and Neurodegeneration”

 

Teaching activity

 

- Member of the Teaching Board of the PhD Doctoral Course in "Molecular and Cellular Biotechnologies", Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo.

- Member of the Quality Assurance Commission of Degree Course B.Sc. in “Biotechnology”, Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo.

- From a.a. 2022/2023: Course “Structural and Functional Biochemistry” in the B.Sc. “Biotechnology”,  Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo

- From a.a. 2022/2023: Course “Molecular biomarkers in sustainable crop production” in the B.Sc. “Sustainable Intensification Of Quality Horticultural Productions”, Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo

- Teaching assistant in Biochemistry 2021, Faculty of Pharmacy and Medicine, “Sapienza” University of Rome, Italy

- Coordinator of the international Framework Agreement between the University of Teramo and the University of Havana (CUBA)

- National Scientific qualification as Full professor in the Italian higher education system (University), in the call 2023/2025 (Ministerial Decree n. 1796/2023) for the disciplinary field of ex 03/D1 - MEDICINAL, TOXICOLOGICAL, NUTRACEUTICAL-FOOD, FERMENTATION AND HEALTH AND WELLBEING PRODUCTS CHEMISTRY

 - National Scientific qualification as Associate Professor (BIOLOGICAL CHEMISTRY, SSD: BIO/10) in the Italian higher education system (University), call 2021/2023 (Ministerial Decree n. 553/2021 and 589/2021)

- Professor of Chemistry and Biology, Lyceum High School 2019, Roma (Italy).

- Professor of Science, Lyceum High School 2018. Roma (Italy).

- Analytical Biochemistry of Environmental Pollutants, “Sapienza” University of Rome 2017, Rome, Italy (lesson on request)

- Practical Biochemistry and molecular biology for high school students. “Bioform” project 2015-2017, Rome, Italy (Foundation for the Advancement of Research in Molecular Medicine – ONLUS)

- Laboratory of Biochemical Methodologies 2012-2015. Faculty of Pharmacy and Medicine, Department of Biochemical Sciences “Sapienza” University of Rome, Italy

 

Research activity

 

Antonio Francioso interest in the chemistry and biochemistry of natural products led him to investigate in detail the chemical and photochemical properties of the bioactive natural stilbenoid trans-resveratrol (RSV), in particular its photochemical stability and photochemical reaction mechanisms after UV-light irradiation, identifying for the first time the new photochemical reaction product 2,4,6-trihydroxyphenanthrene (THP). During this project Dr. Francioso moved to Cuba at the "Toxicology" group directed by Prof. Angel Lamar-Sanchez (University of Havana, Cuba) to study the possible toxic effects of this newly characterized resveratrol photoproduct (THP), paying particular attention to the genotoxic risk that this product could pose to human health.

The scientific interest on natural product chemistry brought Prof. Francioso to improve significantly the chemical stability of trans-resveratrol by studying the interactions of this stilbene complexed with a modified natural biopolymer, i.e. carboxymethylated (1,3/1,6)-β-D-glucan (CMG). RSV/CMG association was also evaluated for its biological potential, in particular for its antiviral activity and this new formulation was patented by the research group of Sapienza University of Rome (EP2674155B1). These investigations carried out during the PhD, conceived in full autonomy by Dr. Francioso and conducted in collaboration with different research groups, have been published in high-impact international scientific journals (Org. Chem. 2014,79, 93814; Med. Chem. 2014, 10:237-45;J. Agric. Food Chem. 2014,62:1520–15255; Bioorg. Med. Chem.2015,23: 8, 1671-1683; Antiviral Res. 2015,123, 15-21; Int. J. Mol. Sci. 2017,18(9), 2006; Int. J. Mol. Sci. 2017,18(5), 967; Phytochem. Lett. 2019, 30: 362-366).

Prof. Francioso carried out a scientific project titled: "Metabolomics-based Elucidation of the Bioactive Principles of Endemic Cuban Medicinal Plants” in the context of a Leibniz-DAAD 2017 grant of which he was holder (2017-2018) at the Department of Bioorganic Chemistry of the Leibniz-IPB institute in Halle (Saale), Germany. In collaboration with the group of Prof. Dr. Ludger Wessjohann, Antonio Francioso studied the endemic medicinal tropical flora of Cuba and was able to isolate and fully characterize the chemical structure of a novel bioactive natural compound by means of advanced spectrometric techniques. This novel natural product is the major component of Phyllanthus orbicularis medicinal plant and was tested for its anti-inflammatory capacity showing promising pharmacological potential in human monocytes. The new compound, (2R,3R)-(−)-3’,4´,5,7-tetrahydroxydihydroflavonol-8-C-β-D-glucopyranoside (named Fideloside), is a C-glycosyl dihydroflavonol and its discovery represents a very important outcome in the field of phytochemistry and more in general of natural products chemistry. C-linked glycosides, as well as the enzymes involved in their metabolism (C-glycosyltranferases and C-glycosidases), are extremely rare in nature and absent in human metabolism. These features can confer to the molecule a unique pharmacological profile and possible applications in different fields. These modifications of plant secondary metabolites are biochemically and evolutionally not well studied and characterized. Enzymes involved in C-glycosyl bond formation are very little known and only small amounts of C-glycosides are formed as byproduct of O-glycosylation. The elucidation of this new peculiar product from the Cuban endemic Phyllanthus orbicularis can represent a starting point for the study and characterization of novel enzymes involved in C-glycosyl phenolics biosynthesis (Molecules 2019,24 (15), 2855).

Prof. Francioso focused his scientific interest also on organic compounds from natural sources other than plants. He studied and characterized the chemical structures of Volatile organic compounds (VOCs) present in the secretion of particular ants belonging to the genus Tapinoma (Dolichoderinae). VOCs are essential for chemical communication in social insects. Ants, for instance, represent a compelling model not only to deal with exocrine products and their ecological functions, but also to gain further insights into the biosynthesis of different natural products. In their anal glands, Tapinoma (Formicidae: Dolichoderinae) ants are able to synthesize a series of volatile compounds as “chemical weapons”, including iridoids and saturated and unsaturated ketones crucial in self-defence and communication. The reservoir of the anal gland of the living animals contains the raw poison in the liquid state. By opening this reservoir in water, the leaking poison floats and releases a typical odor, which is perceived even by crushing the living worker, and which is called “smell of Tapinoma”. The venom of the newly discovered species Tapinoma Darioi was recently characterized by Prof. Francioso and the main biologically relevant compounds (cyclopentanoids and iridoids) were identified and synthesized in laboratory.

The research investigations of Dr. Francioso are also addressed to another interesting class of metabolites, i.e. Olive oil phenolic secoiridoids and sulfur-containing compounds. Sulfur natural products can play a crucial role in the metabolism of several organisms and are often involved as markers and/or as principal players in different biological conditions. Antonio Francioso studies non-canonical natural sulfur compounds with the aim to isolate and characterize the chemical structures of novel key intermediates in the metabolism of organic sulfur, such as sulfane-sulfur species (“zero-valent” sulfur, S0) and heterocyclic sulfur and nitrogen containing compounds. The scientific research on the chemical evolution and the biochemistry of organic sulfur is an essential field of research that is still unexpolored with respect to the knowledge acquired on the biochemistry of other main chemical elements of living organisms, i.e. carbon, oxygen and nitrogen. In the current scientific context of biochemistry, it is extremely important to gain deeper insight and better understand the role of organic sulfur in the metabolism of different species, given the important role that this element covers in primary and fundamental functions of living beings.

 

Publications in peer-reviewed scientific journals

1. Fuentes-León F, Rubio A, Sánchez L, Carrazco M, Wong-Guerra M, Francioso A, Falcón-Hidalgo B, Piloto J, Spengler I, Menck C, Sánchez-Lamar Á (2025). Assessment of the genotoxic and photoprotective effects of Phyllanthus mirificus (Phyllanthaceae). Revista del Jardín Botánico Nacional, 46, 25-34.
2. Mariano A, Bigioni, I, Conrado AB, Francioso A, D'Abusco, AS, Fontana M.(2025). Thiotaurine Attenuates TNF-α-Induced Inflammation in Human Chondrocytes via NF-κB Pathway Suppression and Thiol-Dependent Persulfidation. International journal of molecular sciences, 26(20), 10208.
3. Damiano A, Caioni G, D’Addario C, Merola C, Francioso A, Amorena A (2025). The Invisible Influence: Can Endocrine Disruptors Reshape Behaviors Across Generations?. Stresses, 5, 3, 46, 2025
4. Di Risola D, Laurenti D, Ferraro F, Ciogli A, Manetto S, Gazzilli Y, Federico R, Francioso A, Mosca L and Mattioli R (2025). Spontaneous Reaction of Oleacein and Oleocanthal with Primary Amines: A Biochemical Perspective. Molecules 2025, 30(7), 1645.
5. D’Alessio G, Maldonado-Valderrama J, del Castillo-Santaella T, Sabatucci A, Francioso A, Pittia P, Di Mattia CD (2025). Pea protein’s interfacial behavior and emulsifying capacity as affected by high-pressure homogenization treatments: an in-depth study with dilatational rheology characterization. Food Hydrocolloids, 111427.
6. Di Risola D, Mattioli R, Federico R, Pascarella G, Fontana M, Dainese E, Dufrusine B, Ciogli A, Gasparrini F, Morea V, Villani C, Mosca L, Francioso A* (2025) Green synthesis and two-step chromatographic separation of thiocanthal and thiocanthol: Two novel biologically active sulfur derivatives of oleocanthal and oleacein from extra virgin olive oil Food Chemistry 2025 https://doi.org/10.1016/j.foodchem.2024.141296 Accepted 13 September 2024,
7. Caioni G, Pérez Reyes C, Laurenti D, Chiaradia C, Dainese E, Mattioli R, Di Risola D, Santavicca E, Francioso A* (2024) Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products Antibiotics 2024, 13(11), 1071; https://doi.org/10.3390/antibiotics13111071
8. Fontana M, Gunaydin Akyildiz A, D’Alonzo C, Giovannercole F, Zicchi A, Francioso A, Capuozzo E, De Biase D (2024) Synthesis and Biological Activity of Homohypotaurine Obtained by the Enzyme-Based Conversion of Homocysteine Sulfinic Acid Using Recombinant Escherichia Coli Glutamate Decarboxylase. Molecules 2024, 29(17), 3985; https://doi.org/10.3390/molecules29173985
9. Francioso A*, Jiménez Díaz I A, Pérez Reyes C , González Montelongo C, Pierini M, Villani C, López Bazzocchi I (2024) Isolation and Chemotaxonomic Implications of Tenelloside, a Novel Unusual C-Glycosyl Flavanone from Phyllanthus tenellus Roxb. in Tenerife Island Separations 2024, 11(1), 15, https://doi.org/10.3390/separations11010015. Ranked as Q2 in Analytical Chemistry

10. Mazzoccanti G, Franzini R, Ciogli A, Pierini M, Buonsenso F, Faggi C, Francioso A, Manetto S, and Villani C (2023): Theoretically Predicted and Experimentally Detected Chirality of Dibenzocyclooctynes and Their Triazole Adducts with Azides. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.3c01557. Ranked as Q1 in Organic Chemistry

11. Mattioli R, Maggiore A, Di Risola D, Federico R, D'Erme M, Francioso A, Mosca L (2023): Natural deep eutectic solvents protect RNA from thermal-induced degradation. Archives of Biochemistry and Biophysics, Volume 745, 1 September 2023, 109714 https://doi.org/10.1016/j.abb.2023.109714. Ranked as Q2 in Biochemistry

12. Meshalkina D, Tsvetkova E, Orlova A, Islamova R, Grashina M, Gorbach D, Babakov V, Francioso A, Birkemeyer C, Mosca L, Tarakhovskaya E, Frolov A (2023): First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata. Antioxidants, 12(3), 696; https://doi.org/10.3390/antiox12030696. Ranked as Q1 in Clinical Biochemistry and Q2 in Biochemistry, Cell Biology, Molecular Biology and Physiology
13. Francioso A* (2023): Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds Separations 10 (2), 67. Ranked as Q2 in Analytical Chemistry
14. Orlova A, Kysil E, Tsvetkova E, Meshalkina D, Whaley A, Whaley A, Laub A, Francioso A, Babich O, Wessjohann L, Mosca L, Frolov A, Povydysh M (2022): Phytochemical Characterization of Water Avens (Geum rivale) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents. Plants, 11(21), 2859; https://doi.org/10.3390/plants11212859. Ranked as Q1 in Plant Science; Q1 in Ecology, Evolution, Behaviour and Systematics
15. Di Risola D, Mattioli R, Mazzoccanti G, Manetto S, Trovato M, Fontana M, Mosca L, Francioso A* (2022): Synthesis and Chromatographic Determination of S-Nitrosopantetheine: Exploring Reactivity and Stability in Different Aqueous Solutions. https://doi.org/10.3390/separations9090237. Ranked as Q2 in Analytical Chemistry
16. Mattioli R, Francioso A, Trovato M, (2022): Proline Affects Flowering Time in Arabidopsis by Modulating FLC Expression: A Clue of Epigenetic Regulation? https://doi.org/10.3390/plants11182348. Ranked as Q1 in Plant Science; Q1 in Ecology, Evolution, Behaviour and Systematics
17. Dinarelli S, Longo G, Francioso A, Mosca L, Girasole M (2022): Mechano-Transduction Boosts the Aging Effects in Human Erythrocytes Submitted to Mechanical Stimulation. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms231710180. Ranked as Q1 in Organic Chemistry and Medicine
18. Calcaterra A, Manetto S, Buonsenso F, Francioso A, Pierini M, Villani C (2022): Separation of Monosaccharide Anomers on Photo-Click Cysteine-Based Stationary Phase: The α/β Interconversion Process Studied by Dynamic Hydrophilic Liquid Chromatography. https://doi.org/10.3390/separations9080203. Ranked as Q2 in Analytical Chemistry
19. Di Risola D, Ricci D, Marrocco I, Giamogante F, Grieco M, Francioso A, Vasco-Vidal A, Mancini P, Colotti G, Mosca L, Altieri F (2022): ERp57 Chaperon Protein Protects Neuronal Cells from Aβ-induced toxicity. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15655. Ranked as Q1 in Neurisciences
20. Mattioli R , Di Risola D, Federico R, Ciogli A , Gasparrini F , Villani C , Fontana M , Maggiore A, d’Erme M, Mosca L, and Francioso A* (2022): Effect of Natural Deep Eutectic Solvents on trans-Resveratrol Photo-Chemical Induced Isomerization and 2,4,6-Trihydroxyphenanthrene Electro-Cyclic Formation. https://doi.org/10.3390/molecules27072348. Ranked as Q1 in Chemistry and Pharmaceutical Sciences.
21. Bauduin S, Latini M, Belleggia I, Migliore M, Biancucci M, Mattioli R, Francioso A, Mosca L, Funck D, Trovato M (2022): Interplay between Proline Metabolism and ROS in the Fine Tuning of Root-Meristem Size in Arabidopsis. Plants. 5;11(11):1512. doi: 10.3390/plants11111512. Ranked as Q1 in Plant Sciences; Q1 in Ecology, Evolution, Behaviour and Systematics
22. Di Pietro M, Filardo M, Mattioli R, Francioso A, Raponi G, Mosca L, Sessa R (2022): Extra Virgin Olive Oil-Based Green Formulations With Promising Antimicrobial Activity Against Drug-Resistant Isolates. Frontiers in Pharmacology.3389/fphar.2022.885735. Ranked as Q1 in Pharmacology.
23. Francioso A* and Fontana M (2022): Chemistry of outlandish natural products belonging to sulfur metabolism: Unrevealed green syntheses and separation strategies from the Cavallini’s old school. doi.org/10.3390/separations9020045. Ranked as Q2 in Analytical Chemistry
24. Lopez-Cabeza R and Francioso A* (2022): Chiral pesticides with Asymmetric Sulfur: Extraction, Separation and Determination in different Environmental matrices. doi.org/10.3390/separations9020029. Ranked as Q2 in Analytical Chemistry
25. Mariano A, Bigioni I, D’abusco AS, Conrado AB, Maina S, Francioso A, Mosca L, Fontana M (2022): Pheomelanin effect on UVB radiation-induced oxidation/nitration of L-tyrosine. International Journal of Molecular Sciences, 23(1), 267, 6430. Ranked as Q1 in Organic Chemistry and Medicine
26. Francioso A*, Fanelli S, Maria d’Erme, Lendaro E, Miraglia N, Fontana M, Cavallaro R, Mosca L (2021): Pharmacokinetic properties of a novel formulation of S-adenosyl-l-methionine phytate Amino Acids. doi: 10.1007/s00726-021-03076-7. Ranked as Q1 in Organic Chemistry
27. Francioso A*, Fanelli S, Cavallaro R, Fontana M, Mattioli R, D'erme M, Mosca L (2021): Fluorometric optimized determination of total glutathione in erythrocytes. (2021): Separations, doi.org/ 10.3390/separations8060083. Ranked as Q2 in Analytical Chemistry
28. Zuliani I, Lanzillotta C, Tramutola A, Francioso A, Pagnotta S, Barone E, Perluigi M, Di Domenico F (2021): The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Neurotherapeutics, doi.org/10.1007/s13311-020-00978-4. Ranked as Q1 in Pharmacology and Neurology
29. Francioso A^#, Baseggio Conrado A^#, Mosca L, Fontana M (2020): Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology. Oxidative Medicine and Cellular Longevity, doi.org/10.1155/2020/8294158. Ranked as Q1 in Biochemistry
30. Mardente S*, Aventaggiato M, Mari E, Francioso A, Tafani M, Mosca L, Zicari A, Malyshev I, Kuznetsova L, Valentini F (2020): GO Nanosheets: Promising Nano Carrier for the S29, 1-(2-chloro-2-(4-chlorophenyl-ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d] pyrimidin-4-amine, Therapeutic Agent in Neuroblastoma. International Journal of Molecular Sciences, 21(17), 6430. Ranked as Q1 in Organic Chemistry and Medicine
31. Mattioli R^#, Francioso A^#, Mosca L*, Silva P* (2020): Anthocyanins: A Comprehensive Review Of Their Chemical Properties And Health Effects On Cardiovascular and Neurodegenerative Diseases. Molecules, 25(17), 3809. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
32. Francioso A*, Federico R, Maggiore A, Fontana M, Boffi A, D´Erme M, Mosca L (2020): Green route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil. Molecules, 25(16), 3654. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
33. De Caris G, Grieco M, Maggi M, Francioso A, Armeli F, Mosca L, Pinto A, D'Erme M, Mancini P, Businaro R (2020): Blueberry counteracts BV-2 microglia morphological and functional switch after LPS challenge. Nutrients, 12(6), 1830. Ranked as Q1 in Food Science and and Nutrition and Dietetics
34. Francioso A*, Baseggio Conrado A, Blarzino C, Foppoli C, Montanari E, Dinarelli S, Giorgi A, Mosca L, Fontana M (2020): One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation. Molecules, 25(4) 961. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
35. Francioso A^#, Laštovičková L^#, Mosca L, Boffi A, Bonamore A and Macone A (2019): Gas chromatographic–mass spectrometric method for the simultaneous determination of resveratrol isomers and 2,4,6-trihydroxyphenanthrene in red wines exposed to UV-light. Journal of Agricultural and Food Chemistry, 67(42) acs.jafc.9b05992. Ranked as Q1 in Chemistry, Agricultural and Biological Sciences
36. Francioso A*, Franke K, Villani C, Mosca L, D’Erme M, Frischbutter S, Brandt W, Sanchez-Lamar A and Wessjohann L* (2019): Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol. Molecules, 24(15), 2855. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
37. Francioso A*, Mosca L, Menéndez-Perdomo I, Fanelli S, Fontana M, D’Erme M, Fuentes-Leon F and Sanchez-Lamar A (2019): 2,4,6-trihydroxyphenanthrene, a trans-resveratrol photoreaction byproduct: first evidences of genotoxic risk. Phytochemistry Letters, 30: 362-366. Ranked as Q2 in Plant Science, Agronomy and Crop Sciences
38. Mattioli R^#, Francioso A^#*, D’Erme M, Trovato M, Mancini P, Piacentini L, Casale A.M., Wessjohann L, Gazzino R, Costantino P and Mosca L (2019). Anti-inflammatory activity of polyphenolic extract from Arabidopsis thaliana in Alzheimer’s disease models. International Journal of Molecular Sciences, 20(3). Ranked as Q1 in Organic Chemistry and Medicine
39. D’Eustacchio D, Centorame M, Fanfani A, Senczuk G, Jiménez-Alemán G, Vasco-Vidal A, Méndez Y, Ehlrich A, Wessjohann L and Francioso A* (2019): Iridoids and volatile pheromones of Tapinoma darioi ant: Chemical differences to the closely related species Tapinoma magnum. Chemoecology pp 1–10. Ranked as Q2 in Ecology, Evolution, Behaviour and Systematics and as Q3 in Biochemistry
40. Baseggio Conrado A, Capuozzo E, Mosca L, Francioso A, Fontana M*(2019): Thiotaurine: from Chemical and Biological Properties to Role in H2S Signaling. Advances in Experimental Medicine and Biology, 1155: 755-771. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
41. Fanelli S, Francioso A, Cavallaro R, D'Erme M, Putignano P, Miraglia N, Mosca L* (2018): Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers. International Journal of Clinical Nutrition & Dietetics, 4(2).
42. Montanari E*, Oates A, Di Meo C, Meade J, Cerrone R, Francioso A, Devine D, Coviello T, Mancini P, Mosca L, Matricardi P (2018): Hyaluronan‐Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes. Advanced Healthcare Material, 1701483. Ranked as Q1 in Biomaterials, Biomedical Engineer and Pharmaceutical Sciences
43. Dinarelli S, Longo G, Dietler G, Francioso A, Mosca L, Pannitteri G, Boumis G, Bellelli A, Girasole M* (2018): Erythrocyte’s aging in microgravity highlights how environmental stimuli shape metabolism and morphology. Scientific Reports, 8 (1) 5277. Ranked as Q1 in Multidisciplinary
44. Francioso A*, Dinarelli S, Girasole M, Cervoni L, d’Erme M, Mura F, Boffi A, Montanari E, Mosca L. (2017): Behind Resveratrol Stabilization by Carboxymethylated (1,3/1,6)-β-d-Glucan: Does the Polyphenol Play a Role in Polymer Structural Organization? International Journal of Molecular Sciences, 18 (9), 2006. Ranked as Q1 in Organic Chemistry and Medicine
45. Francioso A*, Fanelli S, Vigli D, Ricceri L, Cavallaro RA, Baseggio Conrado A, Fontana M, D’Erme M, Mosca L. (2017): HPLC determination of bioactive sulfur compounds, amino acids and biogenic amines in biological specimens. Advances in Experimental Medicine and Biology, Taurine 10, 535-549. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
46. Baseggio A*, Maina S, Moseley H, Francioso A, Mosca L, Capuozzo E, Fontana M. (2017): Carbonate anion radical generated by the peroxidase activity of copper, zinc superoxide dismutase: scavenging of radical and protection of enzyme by hypotaurine and cysteine sulfinic acid. Advances in Experimental Medicine and Biology, Taurine 10, 551-561. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
47. Francioso A*, Cossi R, Fanelli S, Mastromarino P, Mosca L (2017): Studies on Trans-Resveratrol/Carboxymethylated (1, 3/1, 6)-β-D-Glucan Association for Aerosol Pharmaceutical Applications. International Journal of Molecular Sciences. 18 (5), 967. Ranked as Q1 in Organic Chemistry and Medicine
48. Murana E*, Pagani F., Basilico B, Sundukova M, Batti L, Di Angelantonio S, Cortese B, Grimaldi A, Francioso A, Heppenstall P, Bregestovski P, Limatola C, Ragozzino D (2017): ATP release during cell swelling activates a Ca 2+ -dependent Cl- current by autocrine mechanism in mouse hippocampal microglia. Scientific Reports. 7, 4184. Ranked as Q1 in Multidisciplinary
49. Montanari E, Di Meo C, Sennato S, Francioso A, Marinelli AL, Ranzo F, Schippa S, Coviello T, Bordi F, Matricardi P* (2017): Hyaluronan acid-cholesterol nanohydrogels: characterization and effectiveness in carrying Alginate Lyase enzyme. New Biotechnology. 37, 80-89. Ranked as Q1 in Bioengineering, Biotechnology and Molecular Biology
50. Bonamore A*, Gargano M, Calisti L, Francioso A, Mosca L, Boffi A, Federico R (2016): A Novel Direct Method for Determination of Riboflavin in Alcoholic Fermented Beverages. Food Analytical Methods. 9 (4), 840-844. Ranked as Q1 in Safety Research and as Q2 in Analytical Chemistry and Food Science
51. Mastromarino P*, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L. (2015): Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia. Antiviral Research. 123, 15-21. Ranked as Q1 in Pharmacology and Virology
52. Francioso A*, Punzi P, Boffi A, Lori C, Martire S, Giordano C, D’Erme M, Mosca L. (2015): β-Sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis. Bioorganic & Medicinal Chemistry. 23 (8), 1671-1683. Ranked as Q2 in Drug Discovery, Organic Chemistry and Pharmaceutical Science and as Q3 in Molecular Medicine and Biology
53. Lattanzi R*, Congiu C, Onnis V, Deplano A, Salvadori S, Marconi V, Maftei D, Francioso A, Ambrosio C, Casella I, Costa T, Caltabiano G, Matsoukas MT, Balboni G, Negri L (2014): Halogenated triazinediones behave as antagonists of PKR1 : in-vitro and in-vivo pharmacological characterization. International Journal of Pharmaceutical Sciences and Research. 6 (3), 1033-1042.
54. Francioso A*, Boffi A, Villani C., Manzi L, d’Erme M, Macone A, Mosca L (2014): Isolation and identification of 2,4,6-trihydroxyphenanthrene as a byproduct of trans-resveratrol photochemical isomerization and electrocyclization. Journal of Organic Chemistry. 79, 9381-4. Ranked as Q1 in Organic Chemistry
55. Francioso A, Mastromarino P, Restignoli R, Boffi A, d’Erme M, Mosca L* (2014): Improved stability of trans-resveratrol in aqueous solutions by carboxymethylated (1,3/1,6)-β-D-glucan. Journal of Agricultural and Food Chemistry. 62:1520–15255. Ranked as Q1 in Chemistry, Agricultural and Biological Sciences
56. Francioso A*, Mastromarino P, Masci A, d’Erme M, Mosca L. (2014): Chemistry, stability and bioavailability of resveratrol. Medicinal Chemistry. 10, 237-45. Ranked as Q3 in Drug Discovery
57. Aureli C, Cassano T*, Masci A, Francioso A, Martire S., Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d’Erme M, Mosca L (2014): 5-S-Cysteinyldopamine neurotoxicity: influence on the expression of α-Synuclein and of ERp57 in cellular and animal models of Parkinson’s disease. Journal of Neuroscience Research. 92:347-58. Ranked as Q2 in Cellular and Molecular Neuroscience
58. Bertollini C*, Murana E, Mosca L, D’Erme M, Scala F, Francioso A, Catalano M, Limatola C, Bregestovski P, Di Angelantonio S, Ragozzino D (2012): Transient increase in neuronal chloride concentration by neuroactive amino acids released from glioma cells. Frontiers in Molecular Neuroscience. 5:100. Ranked as Q1 in Molecular Biology and Cellular and Molecular Neuroscience

 *= Corresponding author                ^#= Co-authorship

Peer-reviewed conference proceedings

 

• Alessia Mariano, Anna Scotto d’Abusco, Antonio Francioso, Alessia Baseggio Conrado, Serena Crucianelli, Mario Fontana (2025) Thiotaurine and Sulfane Sulfur Signaling: A Redox-Based Strategy Against Osteoarthritis Inflammation. SIB Congress 2025

 

• Daniel Di Risola, Carmen Chiaradia, Davide Laurenti, Valentina Giovannelli, Antonio Francioso, Eugenio Lendaro, Roberto Mattioli, Luciana Mosca (2025) Combating Microglia-Driven Neuroinflammation: Unveiling the Anti-Inflammatory Power of Oleacein in a multi-layer study of microglia activation. SIB Congress 2025

 

• Antonella Damiano, Giulia Caion, Carmine Merola, Roberto Mattioli, Daniel Di Risola, Alessandro Piccinini, Annalaura Sabatucci, Antonio Francioso and Michele Amorena (2025) Toxicological assessment of a green bioactive extra virgin olive oil extract in the zebrafish (Danio rerio) model. ProLyon Roma Wokshop 2025

 

• Francioso A. Invited speaker at the "XI International Congress of Chemistry, Biochemistry and Chemical Engineering QUIMICUBA'2024" Plenary conference at the Quimicuba 2024 Natural Products, Biochemistry and Medicinal Chemistry Session - November 4th to 8th, 2024 at the Havana Convention Center, La Habana, Cuba dal 04-11-2024 al 08-11-2024 Invited Speaker

 

• Damianio A, Caioni G, Merola C, Mattioli R, Di Risola D, Piccinini A, Dainese E, Francioso A, Sabatucci A, Amorena M (2024) Toxicological assessment of a green bioactive extra-virgin olive oil extract in the zebrafish model. Best Poster prize, Convegno SIFTVet 2024. 18-19 Aprile, Messina, Italy

 

• Francioso A, Jiménez Diaz I. A, Lopez Bazzocchi I, Mosca L (2022) Resveratrol, a double-edged sword: long life elixir or father of toxic products?. Sustainable and Precision Agriculture Symposium 2022. San Cristobal de La Laguna, Tenerife, Spain. Invited Speaker

 

• Francioso A (2019) C-linked glycosyl polyphenols as promising therapeutic agents: Fideloside, a novel anti-inflammatory 8-C-glycosyl 2,3-dihydroflavonol from the Cuban endemic medicinal plant Phyllanthus orbicularis. PhytoAD symposium, Halle (Saale), Germany. Invited Speaker

 

• Francioso A, Baseggio Conrado A, Capuozzo E, D'Erme M, Mosca L, Fontana M. (2019) Heme catalyzed synthesis of thiotaurine from hypotaurine and hydrogen sulfide: a possible novel biochemical pathway. SIB 2019 60th Congress, Lecce, Italy

 

• Francioso A, Baseggio Conrado A, Capuozzo E, D'Erme M, Mosca L, Fontana M (2019). Reaction of hypotaurine and hydrogen sulfide in the presence of peroxidase: formation of a sulfane sulfur bond (S⁰). Trends in Enzymology and Biocatalysis,  Roma, Italy

 

• Francioso A, Fanelli S, Vigli D, Cavallaro R, Ricceri L, Napoletani G, Fontana M, Baseggio Conrado A, D’Erme M, Mosca L (2016) HPLC method for the determination of sulfur-containing biogenic amines in biological specimens. International Taurine meeting, Seoul, South Korea

 

• Francioso A, Mastromarino P, Capobianco D, Mattia E, De Leo A, Girasole M, Dinarelli S, Boffi A, d’Erme M, Mosca L (2014) Improved Stability of trans-Resveratrol in Aqueous Solutions by Carboxymethylated (1,3/1,6)-β-D-Glucan and Antiviral Properties of this Combination. Nanoscience & Nanotechnology, Istituto Nazionale di Fisica Nucleare, Frascati, Italy

 

• Mastromarino P, Nardis C, Cannata F, De Leo A, Francioso A, Mosca L (2013) Resveratrol Inhibition of Human Rhinovirus Replication. 2nd Antivirals Congress Cambridge, MA, USA

 

• Nardis C, Mattia E, De Leo A, Francioso A, Mosca L, Mastromarino P (2013) Resveratrol Inhibition of Human Rhinovirus Replication. 5th European Congress of Virology Lyon, France

 

• Mosca L, Consalvi V, Chiaraluce R, Martire S, Buoninfante OA, Masci A, Francioso A, d’Erme M (2012) Cellular response to oxidative stress induced by Amyloid β-peptide: in vitro and in vivo studies. Biophysics & Bioeng. Letters Vol. 5(2) Roma, Italy

 

• Mosca L, Aureli C, Masci A, Francioso A, Faraldi M, Gaetani S, Ferraro A, D’Erme M, Cassano T (2011) 5-s-cysteinyldopamine affects the expression of alpha-synuclein and of the thiol oxidoreductase ERp57. V Meeting on the Molecular Mechanisms of Neurodegeneration, Milan, Italy

 

PATENTS. 

 

• Extracts in eutectic solvent of olive oil polyphenols, compositions, uses and methods of preparation thereof WO WO2023218391A1. Applicant: Active-Italia S.R.L. Roma (IT) Inventors: Federico R., Mosca L., Mattioli, R., Francioso A., Miceli E., Berti U. Priority 2022-05-11 • Filed 2023-05-11 • Published 2023-11-16

 

• Stabilizzazione in soluzione e dopo irraggiamento del trans-resveratrolo e altri polifenoli mediante l'utilizzo di solventi eutettici, N. IT 102021000025259. Applicant: Noos S.r.l., Roma (IT) Inventors: Moretti G., Mosca L., Federico R., Francioso A. Priority 2021-10-01 • Filed 2021-10-01 • Granted 2023-22-07

 

• Metodo per la preparazione di olio di oliva con caratteristiche qualitative, sensoriali e nutrizionali determinate. N IT 102023000006075. Applicant Active-Italia S.R.L. Roma (IT) Inventors: Federico R, Mosca L, Francioso A, Mattioli R. Priority 2023-03-29 • Filed 2023-03-29

 

• Protezione dalla degradazione dell'RNA mediante l'utilizzo di solventi eutettici. N IT 102023000009447. Applicant Active-Italia S.R.L. Roma (IT) Inventors: Federico R., Mosca L., Mattioli, R., Maggiore A., Francioso A., Miceli E., Berti U. Priority 11-05-2023 • Filed 11-05-2023