Professional Experience

11/2022 – to date

Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. Assistant Professor in Biological Chemistry

06/2022 – 11/2022

Visiting Professor with the International program “Tomas de Iriarte”; Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain

06/2021 – 05/2022

Department of Biochemical Sciences "A. Rossi Fanelli" Sapienza University of Rome, Italy-International Be-for-ERC post-doctoral fellowship. Project acronym: SulPhenOx

01/2021 – to 03/2021

Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain – FEBS grant.

06/2020 – to 05/2021

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship. Title of the project: "Purification of natural bioactive compounds through a green chemistry approach"

01/2020 – 04/2020

Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, Tenerife, Spain – EMBO grant.

12/2018 – 12/2019

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship. Title of the project: "Chemistry and biological activity of organic natural compounds and sulfur-containing metabolites in cellular models of neurodegeneration"

11/2017 – 11/2018

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB-Halle), Halle (Saale), Germany-Leibniz-DAAD post-doctoral fellowship. Title of the project: "Metabolomics-based Elucidation of the Bioactive Principles of Endemic Cuban Medicinal Plants"

02/2017 - 11/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, and "GNOSIS" S.p.a.- Post-doctoral research project: "Analytical investigations on glutathione thioester derivatives and determination of S-Adenosylmethionine in human plasma"

01/2016 – 01/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Post-doctoral fellowship (FILAS project): "Chemical and biological studies on β-hexachlorocyclohexane, a persistent environmental pollutant of Valle del Sacco (ITALY)"

11/2015-11/2017

Department of Biochemical Sciences "Rossi A. Fanelli" Sapienza University of Rome, Italy- Teaching assistant of molecular biology exercises for high school students in "Bioform project 2015-2017" (Foundation for the Advancement of Research in Molecular Medicine - ONLUS)

03/2015- 09/2015

Faculty of Biology, Department of Plant Biology, University of Havana, Cuba - Visiting scientist: Genotoxicity and mutagenicity of 2,4,6-trihydroxyphenantrene; Extraction and characterization of natural products from endemic tropical flora

11/2012- 11/2015

Sapienza University of Rome, Italy- Teaching assistant of Biochemistry at the Department of Biochemical Sciences

10/2010- 10/2012

Pharmaceutical company "NOOS" S.r.l.- Consultant for antioxidants and natural products development

 

Education

2014/2015

PhD in Biochemistry, “Sapienza” University of Rome

2011/2012

MSc in Pharmaceutical Biotechnology, “Sapienza” University of Rome

Results: 110 /110 cum laude

 

Prizes and Awards received.

 

- “Maria Zambrano” International Talents 2022, University of La Laguna, Spain (Ministry of Science and Innovation, Government of Spain)

- “Tomas de Iriarte” Visiting Professor grant 2022, University of La Laguna, Spain

- Be-for ERC grant 2021, “Sapienza” University of Rome, Italy (€ 50000)

- Federation of European Biochemical Societies FEBS grant 2021 (€ 5700)

- Seal of Excellence 2020: Marie Skłodowska-Curie actions (MSCA) in Horizon 2020 (European Commission)

- European Molecular Biology Organization EMBO Research grant 2019 (€ 6000).

- Sapienza Ateneo Starting Grant 2019 – 2020 - 2021. “Sapienza” University of Rome, Italy (€ 2000 each)

- Leibniz-DAAD Research Fellowship 2017-18: University of Halle, Germany (€ 24000).

- FILAS research grant 2016. Regione Lazio, Italy (€ 19000)

- Best Poster presentation” award at BeMM (Biology and Molecular Medicine) PhD Symposium 2015 “Sapienza” University of Rome, Italy

- Sapienza Ateneo Starting Grant 2015. “Sapienza” University of Rome, Italy (€ 2000)

- Sapienza Ateneo Starting Grant 2014. “Sapienza” University of Rome, Italy (€ 2000)

- “Graduated Excellent” AWARD 2013 from the Dean of “Sapienza” University of Rome, Italy

- Scholarship 2012 “Sapienza” University of Rome. Faculty of Pharmacy and Medicine (€ 1095).

 

Memberships of scientific societies and editorial activity

- Member of the Italian Society of Biochemistry (SIB)

- Member of the Italian Society of Chemistry (SCI)

- Topic editor for the scientific journal Seaparations MDPI. Editor for the Special issue “Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds”

- Guest editor for the scientific journal Molecules MDPI. Editor for the Special issue “Resveratrol News & Views: From the Molecular Mechanism to Nutritional and Biomedical Applications”

 

Teaching activity

- Member of the Teaching Board of the PhD Doctoral Course in "Molecular and Cellular Biotechnologies", Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo.

- Member of the Quality Assurance Commission of Degree Course B.Sc. in “Biotechnology”, Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo.

- From a.a. 2022/2023: Course “Structural and Functional Biochemistry” in the B.Sc. “Biotechnology”,  Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo

- From a.a. 2022/2023: Course “Molecular biomarkers in sustainable crop production” in the B.Sc. “Sustainable Intensification Of Quality Horticultural Productions”, Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo

- Teaching assistant in Biochemistry 2021, Faculty of Pharmacy and Medicine, “Sapienza” University of Rome, Italy

- Professor of Chemistry and Biology, Lyceum High School 2019, Roma (Italy).

- Professor of Science, Lyceum High School 2018. Roma (Italy).

- Analytical Biochemistry of Environmental Pollutants, “Sapienza” University of Rome 2017, Rome, Italy (lesson on request)

- Practical Biochemistry and molecular biology for high school students. “Bioform” project 2015-2017, Rome, Italy (Foundation for the Advancement of Research in Molecular Medicine – ONLUS)

- Laboratory of Biochemical Methodologies 2012-2015. Faculty of Pharmacy and Medicine, Department of Biochemical Sciences “Sapienza” University of Rome, Italy

 

Research activity

Antonio Francioso interest in the chemistry and biochemistry of natural products led him to investigate in detail the chemical and photochemical properties of the bioactive natural stilbenoid trans-resveratrol (RSV), in particular its photochemical stability and photochemical reaction mechanisms after UV-light irradiation, identifying for the first time the new photochemical reaction product 2,4,6-trihydroxyphenanthrene (THP). During this project Dr. Francioso moved to Cuba at the "Toxicology" group directed by Prof. Angel Lamar-Sanchez (University of Havana, Cuba) to study the possible toxic effects of this newly characterized resveratrol photoproduct (THP), paying particular attention to the genotoxic risk that this product could pose to human health.

The scientific interest on natural product chemistry brought Dr. Francioso to improve significantly the chemical stability of trans-resveratrol by studying the interactions of this stilbene complexed with a modified natural biopolymer, i.e. carboxymethylated (1,3/1,6)-β-D-glucan (CMG). RSV/CMG association was also evaluated for its biological potential, in particular for its antiviral activity and this new formulation was patented by the research group of Sapienza University of Rome (EP2674155B1). These investigations carried out during the PhD, conceived in full autonomy by Dr. Francioso and conducted in collaboration with different research groups, have been published in high-impact international scientific journals (Org. Chem. 2014,79, 93814; Med. Chem. 2014, 10:237-45;J. Agric. Food Chem. 2014,62:1520–15255; Bioorg. Med. Chem.2015,23: 8, 1671-1683; Antiviral Res. 2015,123, 15-21; Int. J. Mol. Sci. 2017,18(9), 2006; Int. J. Mol. Sci. 2017,18(5), 967; Phytochem. Lett. 2019, 30: 362-366).

Dr. Francioso carried out a scientific project titled: "Metabolomics-based Elucidation of the Bioactive Principles of Endemic Cuban Medicinal Plants” in the context of a Leibniz-DAAD 2017 grant of which he was holder (2017-2018) at the Department of Bioorganic Chemistry of the Leibniz-IPB institute in Halle (Saale), Germany. In collaboration with the group of Prof. Dr. Ludger Wessjohann, Dr Francioso studied the endemic medicinal tropical flora of Cuba and was able to isolate and fully characterize the chemical structure of a novel bioactive natural compound by means of advanced spectrometric techniques. This novel natural product is the major component of Phyllanthus orbicularis medicinal plant and was tested for its anti-inflammatory capacity showing promising pharmacological potential in human monocytes. The new compound, (2R,3R)-(−)-3’,4´,5,7-tetrahydroxydihydroflavonol-8-C-β-D-glucopyranoside (named Fideloside), is a C-glycosyl dihydroflavonol and its discovery represents a very important outcome in the field of phytochemistry and more in general of natural products chemistry. C-linked glycosides, as well as the enzymes involved in their metabolism (C-glycosyltranferases and C-glycosidases), are extremely rare in nature and absent in human metabolism. These features can confer to the molecule a unique pharmacological profile and possible applications in different fields. These modifications of plant secondary metabolites are biochemically and evolutionally not well studied and characterized. Enzymes involved in C-glycosyl bond formation are very little known and only small amounts of C-glycosides are formed as byproduct of O-glycosylation. The elucidation of this new peculiar product from the Cuban endemic Phyllanthus orbicularis can represent a starting point for the study and characterization of novel enzymes involved in C-glycosyl phenolics biosynthesis (Molecules 2019,24 (15), 2855).

Dr Francioso focused his scientific interest also on organic compounds from natural sources other than plants. He studied and characterized the chemical structures of Volatile organic compounds (VOCs) present in the secretion of particular ants belonging to the genus Tapinoma (Dolichoderinae). VOCs are essential for chemical communication in social insects. Ants, for instance, represent a compelling model not only to deal with exocrine products and their ecological functions, but also to gain further insights into the biosynthesis of different natural products. In their anal glands, Tapinoma (Formicidae: Dolichoderinae) ants are able to synthesize a series of volatile compounds as “chemical weapons”, including iridoids and saturated and unsaturated ketones crucial in self-defence and communication. The reservoir of the anal gland of the living animals contains the raw poison in the liquid state. By opening this reservoir in water, the leaking poison floats and releases a typical odor, which is perceived even by crushing the living worker, and which is called “smell of Tapinoma”. The venom of the newly discovered species Tapinoma Darioi was recently characterized by Dr. Francioso and the main biologically relevant compounds (cyclopentanoids and iridoids) were identified and synthesized in laboratory.

The research investigations of Dr. Francioso are also addressed to another interesting class of metabolites, i.e. Olive oil phenolic secoiridoids and sulfur-containing compounds. Sulfur natural products can play a crucial role in the metabolism of several organisms and are often involved as markers and/or as principal players in different biological conditions. Dr. Francioso studies non-canonical natural sulfur compounds with the aim to isolate and characterize the chemical structures of novel key intermediates in the metabolism of organic sulfur, such as sulfane-sulfur species (“zero-valent” sulfur, S0) and heterocyclic sulfur and nitrogen containing compounds. The scientific research on the chemical evolution and the biochemistry of organic sulfur is an essential field of research that is still unexpolored with respect to the knowledge acquired on the biochemistry of other main chemical elements of living organisms, i.e. carbon, oxygen and nitrogen. In the current scientific context of biochemistry, it is extremely important to gain deeper insight and better understand the role of organic sulfur in the metabolism of different species, given the important role that this element covers in primary and fundamental functions of living beings.

 

Publications in peer-reviewed scientific journals 

1. Francioso A*, Jiménez Díaz I A, Pérez Reyes C , González Montelongo C, Pierini M, Villani C, López Bazzocchi I (2024) Isolation and Chemotaxonomic Implications of Tenelloside, a Novel Unusual C-Glycosyl Flavanone from Phyllanthus tenellus Roxb. in Tenerife Island Separations 2024, 11(1), 15, https://doi.org/10.3390/separations11010015. Ranked as Q2 in Analytical Chemistry

2. Mazzoccanti G, Franzini R, Ciogli A, Pierini M, Buonsenso F, Faggi C, Francioso A, Manetto S, and Villani C (2023): Theoretically Predicted and Experimentally Detected Chirality of Dibenzocyclooctynes and Their Triazole Adducts with Azides. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.3c01557. Ranked as Q1 in Organic Chemistry

3. Mattioli R, Maggiore A, Di Risola D, Federico R, D'Erme M, Francioso A, Mosca L (2023): Natural deep eutectic solvents protect RNA from thermal-induced degradation. Archives of Biochemistry and Biophysics, Volume 745, 1 September 2023, 109714 https://doi.org/10.1016/j.abb.2023.109714. Ranked as Q2 in Biochemistry

4. Meshalkina D, Tsvetkova E, Orlova A, Islamova R, Grashina M, Gorbach D, Babakov V, Francioso A, Birkemeyer C, Mosca L, Tarakhovskaya E, Frolov A (2023): First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata. Antioxidants, 12(3), 696; https://doi.org/10.3390/antiox12030696. Ranked as Q1 in Clinical Biochemistry and Q2 in Biochemistry, Cell Biology, Molecular Biology and Physiology
5. Francioso A* (2023): Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds Separations 10 (2), 67. Ranked as Q2 in Analytical Chemistry
6. Orlova A, Kysil E, Tsvetkova E, Meshalkina D, Whaley A, Whaley A, Laub A, Francioso A, Babich O, Wessjohann L, Mosca L, Frolov A, Povydysh M (2022): Phytochemical Characterization of Water Avens (Geum rivale) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents. Plants, 11(21), 2859; https://doi.org/10.3390/plants11212859. Ranked as Q1 in Plant Science; Q1 in Ecology, Evolution, Behaviour and Systematics
7. Di Risola D, Mattioli R, Mazzoccanti G, Manetto S, Trovato M, Fontana M, Mosca L, Francioso A* (2022): Synthesis and Chromatographic Determination of S-Nitrosopantetheine: Exploring Reactivity and Stability in Different Aqueous Solutions. https://doi.org/10.3390/separations9090237. Ranked as Q2 in Analytical Chemistry
8. Mattioli R, Francioso A, Trovato M, (2022): Proline Affects Flowering Time in Arabidopsis by Modulating FLC Expression: A Clue of Epigenetic Regulation? https://doi.org/10.3390/plants11182348. Ranked as Q1 in Plant Science; Q1 in Ecology, Evolution, Behaviour and Systematics
9. Dinarelli S, Longo G, Francioso A, Mosca L, Girasole M (2022): Mechano-Transduction Boosts the Aging Effects in Human Erythrocytes Submitted to Mechanical Stimulation. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms231710180. Ranked as Q1 in Organic Chemistry and Medicine
10. Calcaterra A, Manetto S, Buonsenso F, Francioso A, Pierini M, Villani C (2022): Separation of Monosaccharide Anomers on Photo-Click Cysteine-Based Stationary Phase: The α/β Interconversion Process Studied by Dynamic Hydrophilic Liquid Chromatography. https://doi.org/10.3390/separations9080203. Ranked as Q2 in Analytical Chemistry
11. Di Risola D, Ricci D, Marrocco I, Giamogante F, Grieco M, Francioso A, Vasco-Vidal A, Mancini P, Colotti G, Mosca L, Altieri F (2022): ERp57 Chaperon Protein Protects Neuronal Cells from Aβ-induced toxicity. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15655. Ranked as Q1 in Neurisciences
12. Mattioli R , Di Risola D, Federico R, Ciogli A , Gasparrini F , Villani C , Fontana M , Maggiore A, d’Erme M, Mosca L, and Francioso A* (2022): Effect of Natural Deep Eutectic Solvents on trans-Resveratrol Photo-Chemical Induced Isomerization and 2,4,6-Trihydroxyphenanthrene Electro-Cyclic Formation. https://doi.org/10.3390/molecules27072348. Ranked as Q1 in Chemistry and Pharmaceutical Sciences.
13. Bauduin S, Latini M, Belleggia I, Migliore M, Biancucci M, Mattioli R, Francioso A, Mosca L, Funck D, Trovato M (2022): Interplay between Proline Metabolism and ROS in the Fine Tuning of Root-Meristem Size in Arabidopsis. Plants. 5;11(11):1512. doi: 10.3390/plants11111512. Ranked as Q1 in Plant Sciences; Q1 in Ecology, Evolution, Behaviour and Systematics
14. Di Pietro M, Filardo M, Mattioli R, Francioso A, Raponi G, Mosca L, Sessa R (2022): Extra Virgin Olive Oil-Based Green Formulations With Promising Antimicrobial Activity Against Drug-Resistant Isolates. Frontiers in Pharmacology.3389/fphar.2022.885735. Ranked as Q1 in Pharmacology.
15. Francioso A* and Fontana M (2022): Chemistry of outlandish natural products belonging to sulfur metabolism: Unrevealed green syntheses and separation strategies from the Cavallini’s old school. doi.org/10.3390/separations9020045. Ranked as Q2 in Analytical Chemistry
16. Lopez-Cabeza R and Francioso A* (2022): Chiral pesticides with Asymmetric Sulfur: Extraction, Separation and Determination in different Environmental matrices. doi.org/10.3390/separations9020029. Ranked as Q2 in Analytical Chemistry
17. Mariano A, Bigioni I, D’abusco AS, Conrado AB, Maina S, Francioso A, Mosca L, Fontana M (2022): Pheomelanin effect on UVB radiation-induced oxidation/nitration of L-tyrosine. International Journal of Molecular Sciences, 23(1), 267, 6430. Ranked as Q1 in Organic Chemistry and Medicine
18. Francioso A*, Fanelli S, Maria d’Erme, Lendaro E, Miraglia N, Fontana M, Cavallaro R, Mosca L (2021): Pharmacokinetic properties of a novel formulation of S-adenosyl-l-methionine phytate Amino Acids. doi: 10.1007/s00726-021-03076-7. Ranked as Q1 in Organic Chemistry
19. Francioso A*, Fanelli S, Cavallaro R, Fontana M, Mattioli R, D'erme M, Mosca L (2021): Fluorometric optimized determination of total glutathione in erythrocytes. (2021): Separations, doi.org/ 10.3390/separations8060083. Ranked as Q2 in Analytical Chemistry
20. Zuliani I, Lanzillotta C, Tramutola A, Francioso A, Pagnotta S, Barone E, Perluigi M, Di Domenico F (2021): The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Neurotherapeutics, doi.org/10.1007/s13311-020-00978-4. Ranked as Q1 in Pharmacology and Neurology
21. Francioso A^#, Baseggio Conrado A^#, Mosca L, Fontana M (2020): Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology. Oxidative Medicine and Cellular Longevity, doi.org/10.1155/2020/8294158. Ranked as Q1 in Biochemistry
22. Mardente S*, Aventaggiato M, Mari E, Francioso A, Tafani M, Mosca L, Zicari A, Malyshev I, Kuznetsova L, Valentini F (2020): GO Nanosheets: Promising Nano Carrier for the S29, 1-(2-chloro-2-(4-chlorophenyl-ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d] pyrimidin-4-amine, Therapeutic Agent in Neuroblastoma. International Journal of Molecular Sciences, 21(17), 6430. Ranked as Q1 in Organic Chemistry and Medicine
23. Mattioli R^#, Francioso A^#, Mosca L*, Silva P* (2020): Anthocyanins: A Comprehensive Review Of Their Chemical Properties And Health Effects On Cardiovascular and Neurodegenerative Diseases. Molecules, 25(17), 3809. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
24. Francioso A*, Federico R, Maggiore A, Fontana M, Boffi A, D´Erme M, Mosca L (2020): Green route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil. Molecules, 25(16), 3654. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
25. De Caris G, Grieco M, Maggi M, Francioso A, Armeli F, Mosca L, Pinto A, D'Erme M, Mancini P, Businaro R (2020): Blueberry counteracts BV-2 microglia morphological and functional switch after LPS challenge. Nutrients, 12(6), 1830. Ranked as Q1 in Food Science and and Nutrition and Dietetics
26. Francioso A*, Baseggio Conrado A, Blarzino C, Foppoli C, Montanari E, Dinarelli S, Giorgi A, Mosca L, Fontana M (2020): One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation. Molecules, 25(4) 961. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
27. Francioso A^#, Laštovičková L^#, Mosca L, Boffi A, Bonamore A and Macone A (2019): Gas chromatographic–mass spectrometric method for the simultaneous determination of resveratrol isomers and 2,4,6-trihydroxyphenanthrene in red wines exposed to UV-light. Journal of Agricultural and Food Chemistry, 67(42) acs.jafc.9b05992. Ranked as Q1 in Chemistry, Agricultural and Biological Sciences
28. Francioso A*, Franke K, Villani C, Mosca L, D’Erme M, Frischbutter S, Brandt W, Sanchez-Lamar A and Wessjohann L* (2019): Insights into the Phytochemistry of the Cuban Endemic Medicinal Plant Phyllanthus orbicularis: Fideloside, a Novel Bioactive 8-C-glycosyl 2,3-Dihydroflavonol. Molecules, 24(15), 2855. Ranked as Q1 in Chemistry and Pharmaceutical Sciences
29. Francioso A*, Mosca L, Menéndez-Perdomo I, Fanelli S, Fontana M, D’Erme M, Fuentes-Leon F and Sanchez-Lamar A (2019): 2,4,6-trihydroxyphenanthrene, a trans-resveratrol photoreaction byproduct: first evidences of genotoxic risk. Phytochemistry Letters, 30: 362-366. Ranked as Q2 in Plant Science, Agronomy and Crop Sciences
30. Mattioli R^#, Francioso A^#*, D’Erme M, Trovato M, Mancini P, Piacentini L, Casale A.M., Wessjohann L, Gazzino R, Costantino P and Mosca L (2019). Anti-inflammatory activity of polyphenolic extract from Arabidopsis thaliana in Alzheimer’s disease models. International Journal of Molecular Sciences, 20(3). Ranked as Q1 in Organic Chemistry and Medicine
31. D’Eustacchio D, Centorame M, Fanfani A, Senczuk G, Jiménez-Alemán G, Vasco-Vidal A, Méndez Y, Ehlrich A, Wessjohann L and Francioso A* (2019): Iridoids and volatile pheromones of Tapinoma darioi ant: Chemical differences to the closely related species Tapinoma magnum. Chemoecology pp 1–10. Ranked as Q2 in Ecology, Evolution, Behaviour and Systematics and as Q3 in Biochemistry
32. Baseggio Conrado A, Capuozzo E, Mosca L, Francioso A, Fontana M*(2019): Thiotaurine: from Chemical and Biological Properties to Role in H2S Signaling. Advances in Experimental Medicine and Biology, 1155: 755-771. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
33. Fanelli S, Francioso A, Cavallaro R, D'Erme M, Putignano P, Miraglia N, Mosca L* (2018): Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers. International Journal of Clinical Nutrition & Dietetics, 4(2).
34. Montanari E*, Oates A, Di Meo C, Meade J, Cerrone R, Francioso A, Devine D, Coviello T, Mancini P, Mosca L, Matricardi P (2018): Hyaluronan‐Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes. Advanced Healthcare Material, 1701483. Ranked as Q1 in Biomaterials, Biomedical Engineer and Pharmaceutical Sciences
35. Dinarelli S, Longo G, Dietler G, Francioso A, Mosca L, Pannitteri G, Boumis G, Bellelli A, Girasole M* (2018): Erythrocyte’s aging in microgravity highlights how environmental stimuli shape metabolism and morphology. Scientific Reports, 8 (1) 5277. Ranked as Q1 in Multidisciplinary
36. Francioso A*, Dinarelli S, Girasole M, Cervoni L, d’Erme M, Mura F, Boffi A, Montanari E, Mosca L. (2017): Behind Resveratrol Stabilization by Carboxymethylated (1,3/1,6)-β-d-Glucan: Does the Polyphenol Play a Role in Polymer Structural Organization? International Journal of Molecular Sciences, 18 (9), 2006. Ranked as Q1 in Organic Chemistry and Medicine
37. Francioso A*, Fanelli S, Vigli D, Ricceri L, Cavallaro RA, Baseggio Conrado A, Fontana M, D’Erme M, Mosca L. (2017): HPLC determination of bioactive sulfur compounds, amino acids and biogenic amines in biological specimens. Advances in Experimental Medicine and Biology, Taurine 10, 535-549. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
38. Baseggio A*, Maina S, Moseley H, Francioso A, Mosca L, Capuozzo E, Fontana M. (2017): Carbonate anion radical generated by the peroxidase activity of copper, zinc superoxide dismutase: scavenging of radical and protection of enzyme by hypotaurine and cysteine sulfinic acid. Advances in Experimental Medicine and Biology, Taurine 10, 551-561. Ranked as Q2 in Biochemistry, Genetics and Molecular Biology and as Q3 in Medicine
39. Francioso A*, Cossi R, Fanelli S, Mastromarino P, Mosca L (2017): Studies on Trans-Resveratrol/Carboxymethylated (1, 3/1, 6)-β-D-Glucan Association for Aerosol Pharmaceutical Applications. International Journal of Molecular Sciences. 18 (5), 967. Ranked as Q1 in Organic Chemistry and Medicine
40. Murana E*, Pagani F., Basilico B, Sundukova M, Batti L, Di Angelantonio S, Cortese B, Grimaldi A, Francioso A, Heppenstall P, Bregestovski P, Limatola C, Ragozzino D (2017): ATP release during cell swelling activates a Ca 2+ -dependent Cl- current by autocrine mechanism in mouse hippocampal microglia. Scientific Reports. 7, 4184. Ranked as Q1 in Multidisciplinary
41. Montanari E, Di Meo C, Sennato S, Francioso A, Marinelli AL, Ranzo F, Schippa S, Coviello T, Bordi F, Matricardi P* (2017): Hyaluronan acid-cholesterol nanohydrogels: characterization and effectiveness in carrying Alginate Lyase enzyme. New Biotechnology. 37, 80-89. Ranked as Q1 in Bioengineering, Biotechnology and Molecular Biology
42. Bonamore A*, Gargano M, Calisti L, Francioso A, Mosca L, Boffi A, Federico R (2016): A Novel Direct Method for Determination of Riboflavin in Alcoholic Fermented Beverages. Food Analytical Methods. 9 (4), 840-844. Ranked as Q1 in Safety Research and as Q2 in Analytical Chemistry and Food Science
43. Mastromarino P*, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L. (2015): Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia. Antiviral Research. 123, 15-21. Ranked as Q1 in Pharmacology and Virology
44. Francioso A*, Punzi P, Boffi A, Lori C, Martire S, Giordano C, D’Erme M, Mosca L. (2015): β-Sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis. Bioorganic & Medicinal Chemistry. 23 (8), 1671-1683. Ranked as Q2 in Drug Discovery, Organic Chemistry and Pharmaceutical Science and as Q3 in Molecular Medicine and Biology
45. Lattanzi R*, Congiu C, Onnis V, Deplano A, Salvadori S, Marconi V, Maftei D, Francioso A, Ambrosio C, Casella I, Costa T, Caltabiano G, Matsoukas MT, Balboni G, Negri L (2014): Halogenated triazinediones behave as antagonists of PKR1 : in-vitro and in-vivo pharmacological characterization. International Journal of Pharmaceutical Sciences and Research. 6 (3), 1033-1042.
46. Francioso A*, Boffi A, Villani C., Manzi L, d’Erme M, Macone A, Mosca L (2014): Isolation and identification of 2,4,6-trihydroxyphenanthrene as a byproduct of trans-resveratrol photochemical isomerization and electrocyclization. Journal of Organic Chemistry. 79, 9381-4. Ranked as Q1 in Organic Chemistry
47. Francioso A, Mastromarino P, Restignoli R, Boffi A, d’Erme M, Mosca L* (2014): Improved stability of trans-resveratrol in aqueous solutions by carboxymethylated (1,3/1,6)-β-D-glucan. Journal of Agricultural and Food Chemistry. 62:1520–15255. Ranked as Q1 in Chemistry, Agricultural and Biological Sciences
48. Francioso A*, Mastromarino P, Masci A, d’Erme M, Mosca L. (2014): Chemistry, stability and bioavailability of resveratrol. Medicinal Chemistry. 10, 237-45. Ranked as Q3 in Drug Discovery
49. Aureli C, Cassano T*, Masci A, Francioso A, Martire S., Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d’Erme M, Mosca L (2014): 5-S-Cysteinyldopamine neurotoxicity: influence on the expression of α-Synuclein and of ERp57 in cellular and animal models of Parkinson’s disease. Journal of Neuroscience Research. 92:347-58. Ranked as Q2 in Cellular and Molecular Neuroscience
50. Bertollini C*, Murana E, Mosca L, D’Erme M, Scala F, Francioso A, Catalano M, Limatola C, Bregestovski P, Di Angelantonio S, Ragozzino D (2012): Transient increase in neuronal chloride concentration by neuroactive amino acids released from glioma cells. Frontiers in Molecular Neuroscience. 5:100. Ranked as Q1 in Molecular Biology and Cellular and Molecular Neuroscience

 *= Corresponding author                ^#= Co-authorship

Peer-reviewed conference proceedings

 

• Damianio A, Caioni G, Merola C, Mattioli R, Di Risola D, Piccinini A, Dainese E, Francioso A, Sabatucci A, Amorena M (2024) Toxicological assessment of a green bioactive extra-virgin olive oil extract in the zebrafish model. Best Poster prize, Convegno SIFTVet 2024. 18-19 Aprile, Messina, Italy

 

• Francioso A, Jiménez Diaz I. A, Lopez Bazzocchi I, Mosca L (2022) Resveratrol, a double-edged sword: long life elixir or father of toxic products?. Sustainable and Precision Agriculture Symposium 2022. San Cristobal de La Laguna, Tenerife, Spain. Invited Speaker

 

• Francioso A (2019) C-linked glycosyl polyphenols as promising therapeutic agents: Fideloside, a novel anti-inflammatory 8-C-glycosyl 2,3-dihydroflavonol from the Cuban endemic medicinal plant Phyllanthus orbicularis. PhytoAD symposium, Halle (Saale), Germany. Invited Speaker

 

• Francioso A, Baseggio Conrado A, Capuozzo E, D'Erme M, Mosca L, Fontana M. (2019) Heme catalyzed synthesis of thiotaurine from hypotaurine and hydrogen sulfide: a possible novel biochemical pathway. SIB 2019 60th Congress, Lecce, Italy

 

• Francioso A, Baseggio Conrado A, Capuozzo E, D'Erme M, Mosca L, Fontana M (2019). Reaction of hypotaurine and hydrogen sulfide in the presence of peroxidase: formation of a sulfane sulfur bond (S⁰). Trends in Enzymology and Biocatalysis,  Roma, Italy

 

• Francioso A, Fanelli S, Vigli D, Cavallaro R, Ricceri L, Napoletani G, Fontana M, Baseggio Conrado A, D’Erme M, Mosca L (2016) HPLC method for the determination of sulfur-containing biogenic amines in biological specimens. International Taurine meeting, Seoul, South Korea

 

• Francioso A, Mastromarino P, Capobianco D, Mattia E, De Leo A, Girasole M, Dinarelli S, Boffi A, d’Erme M, Mosca L (2014) Improved Stability of trans-Resveratrol in Aqueous Solutions by Carboxymethylated (1,3/1,6)-β-D-Glucan and Antiviral Properties of this Combination. Nanoscience & Nanotechnology, Istituto Nazionale di Fisica Nucleare, Frascati, Italy

 

• Mastromarino P, Nardis C, Cannata F, De Leo A, Francioso A, Mosca L (2013) Resveratrol Inhibition of Human Rhinovirus Replication. 2nd Antivirals Congress Cambridge, MA, USA

 

• Nardis C, Mattia E, De Leo A, Francioso A, Mosca L, Mastromarino P (2013) Resveratrol Inhibition of Human Rhinovirus Replication. 5th European Congress of Virology Lyon, France

 

• Mosca L, Consalvi V, Chiaraluce R, Martire S, Buoninfante OA, Masci A, Francioso A, d’Erme M (2012) Cellular response to oxidative stress induced by Amyloid β-peptide: in vitro and in vivo studies. Biophysics & Bioeng. Letters Vol. 5(2) Roma, Italy

 

• Mosca L, Aureli C, Masci A, Francioso A, Faraldi M, Gaetani S, Ferraro A, D’Erme M, Cassano T (2011) 5-s-cysteinyldopamine affects the expression of alpha-synuclein and of the thiol oxidoreductase ERp57. V Meeting on the Molecular Mechanisms of Neurodegeneration, Milan, Italy