Studi

2000 Laurea in Chimica e Tecnologia Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Bologna (tesi in Farmacologia, tutor Prof. Romualdi)
2005 Dottore di Ricerca in Farmacologia e Tossicologia, Università degli Studi di Bologna (tutor Prof. Romualdi)
2008 Diploma di studi Post-dottorato presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden (supervisor Prof Terenius)

Carriera Professionale

1999 - 2000 periodo di ricerca per svolgimento tesi di laurea presso la "School of Medicine, National Parkinson Foundation, University of Miami", Miami, FL, USA, supervisor Prof. Izenwasser.
2002 periodo di Ricerca presso il Dipartimento di Farmacologia e Farmacoterapia alla "Semmelweis University", Budapest, Hungary, partecipante progetto intergovernamentale Italia-Ungheria.
2003 - 2004 Ricercatore ospite presso NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA
2006 - 2009 Ricercatore ospite presso il Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden, 

2009 - 2010 Borsista post-dottorato ed assegnista senior dell' Universitá degli Studi di Bologna

da dicembre 2010 Ricercatore Biologia Molecolare (BIO/11), Facoltà di Agraria, Università degli Studi di Teramo

2013-2014 Ricercatore ospite presso il Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden (https://www.cmm.ki.se/en/members/?id=1023)

Novembre 2019 Guest Professor, University of Cordoba, Cordoba, Argentina.

da settembre 2013 Ricercatore affiliato al Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden 

(https://ki.se/en/people/clauda)

da gennaio 2019 Professore Associato di Biologia Molecolare (BIO/11), Facoltà di Bioscienze, Università degli Studi di Teramo

 

Premi Ricevuti

° Vincitore Borse di Studio Marco Polo, Bologna 2003 e 2006
° Miglior Poster XIV SINPF; Bologna. 1-4 Giugno, 2004.
° Miglior Poster Premio "Emilio Marmo". 32° Congresso SIF; Napoli, 1-4 Giugno 2005.
° Vincitore della Borsa di Studio "C.M. Lerici" dell' Istituto di Cultura Italiana a Stoccolma, Settembre 2006,
° Fellowship Award 22nd ECNP Congress; Istanbul, Turkey, 12 -16 September 2009
° Miglior Poster INNOPSY09; Milano, 18-20 Novembre, 2009
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, ricevuto a WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.

° Miglior Poster ricerca clinica XVII SINPF; Cagliari 22-25 Settembre 2010.

° Vincitore della "C.M. Lerici" per ricercatori' Istituto di Cultura Italiana a Stoccolma, Settembre 2013,

 

Membro delle seguenti società scientifiche

 

Societ. Italiana di Farmacologia; European College of Neuropsychopharmacology; Societ. Italiana di

Neuropscicofarmacologia; Mediterranean Neuroscience Society; Society for Neuroscience; Epigenetic Society; Societ.

Italiana di Biochimica e Biologia Molecolare

Conoscenze Linguistiche

- Inglese
- Svedese base

 

Responsabilità di studi e ricerche scientifiche come PI o coPI

 

2013-2017 National Coordinator of the Project FIRB (Fondo per gli Investimenti della Ricerca di Base, Italian Ministry

of University and Research) entitled: “Epigenetic modulation of eating disorders and obesity: searching for new

pharmacotherapies” (Code: RBFR12DELS_001)

2016-2017 PI of the project entitled “Eating disorders and obesity: Impact of vegetal extracts on development,

progression and genes transcription regulation”.

2016-2017 coPI of the project entitled “Brain Derived Neuratrophic Factor (BDNF) Promotors-I, IX Methylation

Patterns in early onset Bipolar Disorder Patients: Methylation Markers of age at onset, and Interaction with Val66Met

Variance”, financed by Mayo-Karolinska innovation platform

2017-2018 PI of the project entitled “Epigenetic regulation of target genes in peripheral blood mononuclear cells of

Frontotemporal Dementia subjects by selected phytocannabinoids”.

2016-2020 coPI and Tutor Early Stage Researcher in the REPEAT EU project Horizon 2020 Marie Skłodowska-Curie

grant agreement No 713714 http://repeat.unite.it/About_us

2021-2023 coPI progetto FISR, Italian Ministry of University and Research. “Disturbi Indotti dall’Esposizione prenatale

al THC: Approccio Multidisciplinare ed Effetti di Integratori nella dieta materna”

2023-2025 co PI  progetto PNRR-MAD-2022-12376693 - BipOlAR Disorder Integrative stagiNG: incorporating the role of biomarkers into Progression AcrosS Stages (BOARDING-PASS), Ministero della Salute.

2023-2025 coPI progetto  “Maternal exposure to the non-psychoactive phytocannabinoid cannabidiol: a multidisciplinary and longitudinal approach toassess its impact on maternal behaviour and progeny neurodevelopment”, PRIN, Ministero dell'Università e della Ricerca

2023-2025 coPI progetto dal titolo “Valutazione di trattamenti che possano inibire gli effetti negativi dovuti ad esposizione prenatale ad alcol” finanziato da CUIA - CONICET 2022 progetti di cooperazione bilaterale Italia-Argentina

 

Partecipazione come relatore a più di 92 convegni (di cui in 20 come invited speaker) di carattere scientifico in Italia o

all'estero (10 AWARDS) dal 01-01-2000 

 

 

Documenti: 115 (Citazioni: 3050) h-index: 32 (al 27 Luglio 2024)

https://www.scopus.com/authid/detail.uri?authorId=6505862291

 

Partecipazione a comitati editoriali di riviste

 

• Partecipazione a Volume: Molecular Aspects of Alcohol and Nutrition, Volume in the Molecular Nutrition

Series, Edited by:Vinood B. Patel ISBN: 978-0-12-800773-0. Chapter 21 - Alcohol and Epigenetic.

Modulations, Pages 261-273, http://www.sciencedirect.com/science/book/9780128007730

• Partecipazione a Volume: In: Endocannabinoid Signaling. Methods in Molecular Biology, vol 1412.

Humana Press, New York, NY Assessing Gene Expression of the Endocannabinoid System. Methods Mol

Biol. (2016) 1412:237-46.

• Partecipazione a Volume: L’epigenetica. I radicali liberi e la loro rilevanza in biomedicine (2016). Appendice

B

• Guest Associate Editor for Neuroenergetics, Nutrition and Brain Health. Research Topic "Molecular Clues to

Food Addiction-like Behavior"

 

Attività di revisione

 

- per riviste internazionali indicizzate: Alcohol Research & Health, Biological Psychiatry, Brain, Behavior and

Immunity, British Journal of Pharmacology, Cannabis & Cannabinoids, European Neuropsycopharmacology,

Journal of Alzheimer Disease, Neuroscience & Biobehavioral Reviews, Phytotherapy, PLoS One, Scientific

Reports, Translational Psychiatry,

- per valutazione di progetti di ricerca internazionali: Parkinson's Disease Society of the United Kingdom; the

Croatian Science Foundation; Israel Science Foundation; Poland National Science Centre.

 

Risultati ottenuti nel trasferimento tecnologico in termini di partecipazione alla commercializzazione di brevetti

 

- Brevetto d'invenzione "METODO PER DETERMINARE IL DEFICIT DI ATTENZIONE CON IPERATTIVIT."

depositato al n. 102016000129938 dal 10-02-2017

- Brevetto d'invenzione “Composizione per la prevenzione e trattamento della dermatite atopica” depositato al n.

102019000003325 dal 07-03-2019

Education

2000 Degree in Chemistry and Pharmaceutical Technology, Faculty of Pharmacy at the University of Bologna, Italy

2005 PhD in Pharmacology and Toxicology, University of Bologna, Italy (supervisor Prof. Romualdi)

2008 Diploma Post-doc Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sweden (supervisor Prof. Lars Terenius)

Experience and Occupations


1999 - 2000 period of research in the School of Medicine, National Parkinson Foundation, University of Miami, USA, joining Prof. Izenwasser laboratory.
2002 Period of Research in the Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary, as an Italian participant of the Italian-Hungarian Intergovernmental S&T Project.
2003 - 2004 Guest Researcher at NIH/NIDA/IRP Molecular Neurobiology Branch in Baltimore (MD), USA. 
2006 - 2009 Postdoc fellow at Department of Clinical Neuroscience - Karolinska Institutet, Stockholm (Sweden).
2009 - 2010 Postdoctoral senior fellow at Department of Pharmacology, University of Bologna, Italy

since december 2010 Researcher in Molecular Biology at the University of Teramo

November 2019 Guest Professor, University of Cordoba, Cordoba, Argentina

2013-2014 Guest Researcher Karolinska Institute, Center of Molecular Medicine, Stockholm, Sweden

since september 2013 Affiliated Reseacher Department of Clinical Neuroscience, Karolinksa Institute, Stockholm, Sweden

since January 2019 Associate Professor of Molecular Biology, University of Teramo

Awards

° Best Poster XIV SINPF; 1-4 June, 2004, Bologna, Italy.
° Best Poster Price "Emilio Marmo". 32° Congress of the Italian Society of Pharmacology; 1-4 June 2005, Napoli, Italy.
° Research Fellowship Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2006.
° Research Fellowship of the University of Bologna "Marco Polo" for the promotion in foreign country of young researcher (2003 and 2006).
° Fellowship Award 22nd ECNP Congress. 12 -16 September 2009 Istanbul, Turkey.
° Best Poster INNOPSY09; 18-20 Novembe 2009, Milano, Italy
° Travel Award INRC 2010; July 11 - 16, 2010, Malmö, Sweden
° EPHAR Young Investigator Award 2010, WorldPharma2010 Copenhagen
° Travel Award 23nd ECNP Congress. 28 August - 1 September 2010. Amsterdam, The Netherlands.

° Best poster Clinical Research XVII SINPF; 20-24 September, 2010, Cagliari, Italy.

° Research Award from the Italienska Kulturinstitutet "C.M. Lerici", Stockholm, Sweden, 2013.

Languages

- Mother tongue: italian
- English
- Basic Swedish

 

Pubblicazioni scientifiche su riviste internazionali con Imapct Factor:

List of Peer-reviewed Publications

 

 

Romualdi P, D'Addario C, Ferri S, Cox BM, Izenwasser S. Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. Eur. J. Pharmacol. 2001;413: 207-212

 

Collins SL, D'Addario C, Izenwasser S. Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. Eur J Pharmacol. 2001; 426: 25-34.

 

Collins SL, Gerdes RM, D'Addario C, Izenwasser S. Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity. Behav Pharmacol. 2001 Jul; 12(4):237-45.

 

Collins S, D'Addario C, Romualdi P, Candeletti S, Izenwasser S. Regulation of dynorphin gene expression by kappa-opioid agonist treatment. Neuroreport. 2002; 13: 107-109.

 

Romualdi P, Landuzzi D, D'Addario C, Candeletti S. Modulation of proorphaninFQ/N gene expression by morphine in the rat mesocorticolimbic system. Neuroreport. 2002;13(5):645-8.

 

Bregola G, Zucchini S, Candeletti S, Rodi D, Binaschi A, D'Addario C, Landuzzi D, Reinscheid R, Romualdi P, Simonato M. Involvement of the Neuropeptide Nociceptin/Orphanin FQ in Kainate Seizures. J. of Neuroscience. 2002; 22: 10030-10038.

 

Di Benedetto M, D'Addario C, Collins S, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. J. Mol. Neurosci. 2004; 22: 213-222.

 

D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Differential time course of the effects of Kappa-Opioid agonist treatment on dynorphin A levels and on Kappa-Opioid receptor density. J. Mol. Neurosci. 2004; 24: 307-314.

 

Di Benedetto M, D'Addario C, Feliciani D, Izenwasser S, Candeletti S, Romualdi P. Effects of the selective norepinephrine uptake inhibitor on the prodynorphin gene expression in rat CNS. Mol. Brain Res. 2004; 127: 115-120.

 

D'Addario C, Di Benedetto M, Candeletti S, Romualdi P, Effects of MDMA administration on the prodynorphin system activity in the rat brain, Neuroscience 2006; 137: 187-196.

 

Drgon T, D'Addario C, Uhl GR, Linkage Disequilibrium and haplotype analysis of polymorphisms in the GABA receptor cluster on chromosome 4: association study, Am J Med Genet B Neuropsychiatr Genet. 2006; 141: 854-860.

 

Király KP, Riba P, D'Addario C, Di Benedetto M, Candeletti S, Romualdi P and Furst, Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxy-metopon and oxycodone-6-oxime, Brain Res. Bull, 2006; 70: 233-239.

 

D'Addario C, Di Benedetto M, Izenwasser S, Candeletti S, Romualdi P. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS, Neuroscience 2007; 144: 157-164.

 

Di Benedetto M, D'Addario C, Candeletti S, Romualdi P, Alterations of CREB and DARPP-32 activation following cocaine and monoaminergic uptake inhibitors, Brain Res. 2007; 1128: 33-39.

 

D'Addario C, Di Benedetto M, Candeletti S, Romualdi P. The k-opioid receptor agonist U-69593 prevents cocaine-induced DARPP-32 activation in the rat brain, Brain Res. Bull, 2007; 73: 34-9.

 

Romualdi P, Di Benedetto M, D'Addario C, Collins SL, Wade D, Candeletti S, Izenwasser S, Chronic cocaine produces decreases in nociceptin in select brain regions. J Mol Neurosci. 2007; 31: 159-164

 

Vukojevic V, Ming Y, D'Addario C, Johansson B, Rigler R, Terenius L. Fluorescence Correlation Spectroscopy (FCS) study of mu-opioid receptor dynamics in live cells; FEBS JOURNAL Volume: 274 Pages: 107-107, 2007.

 

D'Addario C^§, Ming Y, Ögren SO, Terenius L, Effects of Ethanol and Role of Acetaldehyde on the Expression of endogenous opioid System Genes in SH-SY5Y Cells. FASEB J, 2008; 22: 662-670. ^§ corresponding author

 

Vukojević V, Ming Y, D'Addario C, Rigler R, Johansson B, Terenius L. Ethanol/naltrexone interactions at the mu-opioid receptor. CLSM/FCS study in live cells. PLoS One. 2008;3(12):e4008.

 

Vukojević V, Ming Y, D'Addario C, Hansen M, Langel U, Schulz R, Johansson B, Rigler R, Terenius L. Mu-opioid receptor activation in live cells. FASEB J. 2008 Oct;22(10):3537-48.

 

Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O. The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res. 2008 Dec 16;195(1):54-77.

 

Di Benedetto M, Cavina C, D'Addario C, Leoni G, Candeletti S, Cox BM, Romualdi P. Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats. Neuropharmacology. 2009 Mar;56(4):761-77.

 

D'Addario C^§, Johansson S, Romualdi P, Ogren SO, Terenius L, Ekstrom TJ. Epigenetic effects of ethanol and acetaldehyde exposure in the prodynorphin gene promoter in a human neuroblastoma cell line. FASEB J 2011 Mar;25(3):1069-75. ^§ corresponding author

 

Di Benedetto M, Bastías Candia SC, D'Addario C Porticella E, Cavina C, Candeletti S and Romualdi P.Regulation of opioid genes expression in the rat brainstem by 3,4-Methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade Naunyn-Schmiedeberg Archives of Pharmacology 2011383(2):169-78.

 

D'Addario C^§, Caputi FF, Candeletti S, Rimondini R, Romualdi P. Different Alcohol exposures induce selective alterations on the expression of Dynorphin and Nociceptin Systems Related Genes in Rat Brain. Addiction Biology 18(3):425-33. ^§ corresponding author

 

D'Addario, C^§; Caputi, FF; Candeletti, S; et al. A role for epigenetic mechanisms in the regulation of prodynorphin expression by alcohol. Pharmacological Reports 2011; 63: 208-209. ^§ corresponding author

 

Di Benedetto, M; D'Addario, C^§; Dell'Osso, B; et al. Investigation on DNA methylation status of opioid peptides promoters in PBMCs of subjects with bipolar disorder Pharmacological Reports 2011; 63: 263-264. ^§ corresponding author

 

Arosio B*, Bulbarelli A, Bastias Candia S, Lonati E, Mastronardi L, Romualdi P, Candeletti S, Gussago  C, Galimberti D, Scarpini E, Dell’Osso B, Altamura AC, Maccarrone M, Bergamaschini L, D’Addario C*, Mari D. Pin1 Contribution to Alzheimer’s Disease: Transcriptional and Epigenetic Mechanisms in Patients with Late-Onset Alzheimer’s Disease. * equal contribution. Neurodegenerative Dis 2012; 10: 207-211.

 

D'Addario C^§, Dell'Osso B, Palazzo MC, Benatti B, Lietti L, Cattaneo E, Galimberti D, Fenoglio C,  Cortini F, Scarpini E, Arosio B, Di Francesco A, Di Benedetto M,  Romualdi P, Candeletti S, Mari D, Bergamaschini L, Bresolin N, Maccarrone M, Altamura AC. Selective DNA methylation of BDNF promoter in Bipolar Disorder: differences among patients with BDI and BDII. Neuropsychopharmacology 2012 37: 1647-1655. ^§ corresponding author

 

D'Addario C^§, Di Francesco A, Arosio B, Gussago C, Dell'osso B, Bari M, Galimberti D, Scarpini E, Altamura AC, Mari D, Maccarrone M^§. Epigenetic regulation of Fatty Acid amide hydrolase in Alzheimer disease. PLoS One. 2012;7(6):e39186. ^§ corresponding author

 

Maccarrone M*, D’Addario C*, Di Francesco A, Trabace L, Finazzi Agrò A, Cuomo V Modulation of the endocannabinoid system in Alzheimer’s disease. * equal contribution. European J of Neurodeg dis 1, 67-78.

 

Galimberti D, D'Addario C, Dell'osso B, Fenoglio C, Marcone A, Cerami C, Cappa SF, Palazzo MC, Arosio B, Mari D, Maccarrone M, Bresolin N, Altamura AC, Scarpini E. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Neurol Sci. 2013 Jun;34(6):899-903

 

D'Addario C^§, Caputi FF, Ekström TJ, Di Benedetto M, Maccarrone M, Romualdi P, Candeletti S. Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci. 2013; 49(2):312-9. ^§ corresponding author

 

D’Addario C^§, Dell’Osso B^§, Galimberti D, Palazzo MC, Benatti B, Di Francesco A, Altamura AC, Maccarrone M. Epigenetic Modulation of BDNF gene in Patients with Major Depressive Disorder. Biol Psych 2013 Jan 15;73(2):e6-7. ^§ corresponding authors

 

D'Addario C^§, Di Francesco A, Pucci M, Finazzi Agrò A, Maccarrone M^§. Epigenetic mechanisms and endocannabinoid signalling. FEBS J. 2013 May; 280(9):1905-17. ^§ corresponding author

 

Di Francesco A, Arosio B, Gussago C, Dainese E, Mari D, D'Addario C^§, Maccarrone M*. J Alzheimers Dis. 2013;37(1):3-8. Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation. ^§ corresponding authors

 

Pucci M, Rapino C, Di Francesco A, Dainese E, D'Addario C^§, Maccarrone M^§. Epigenetic control of skin differentiation genes by phytocannabinoids. Br J Pharmacol. 2013 Oct;170(3):581-91. ^§ corresponding authors

 

Caputi FF, Di Benedetto M, Carretta D, Bastias del Carmen Candia S, D'Addario C, Cavina C, Candeletti S, Romualdi P. Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:36-46.

 

Bastías-Candia S, Di Benedetto M, D'Addario C, Candeletti S, Romualdi P. Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease. Environ Toxicol. 2013 Dec 23. doi: 10.1002/tox.21943.

 

D' Addario C^§, Di Francesco A, Trabace L, Finazzi Agro' A, Cuomo V, Maccarrone M^§. Endocannabinoid signaling in Alzheimer’s disease: current knowledge and future directions. J Biol Regul Homeost Agents. 2013 Apr-Jun;27(2 Suppl):61-73. ^§ corresponding authors

 

Arosio B*, D'Addario C*, Gussago C, Casati M, Tedone E, Ferri E, Nicolini P, Rossi PD, Maccarrone M, Mari D. Peripheral blood mononuclear cells as alaboratory to study dementia in the elderly. Biomed Res Int. 2014;2014:169203. * equal contribution

 

Dell'Osso B*^§, D'Addario C*^§, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Di Francesco A, Maccarrone M, Altamura AC. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord. 2014 Sep;166:330-3. * equal contribution ^§ corresponding authors

 

D'Addario C^§, Micioni Di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M^§. Endocannabinoid signaling and food addiction. Neurosci Biobehav Rev. 2014 Aug 27;47C:203-224. ^§ corresponding authors

 

Di Francesco A, Falconi A, Di Germanio C, Micioni Di Bonaventura MV, Costa A, Caramuta S, Del Carlo M, Compagnone D, Dainese E, Cifani C, Maccarrone M, D'Addario C^§. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J Nutr Biochem. 2015 Mar;26(3):250-8. ^§ corresponding authors

 

Di Francesco A, Arosio B, Falconi A, Micioni Di Bonaventura MV, Karimi M, Mari D, Casati M, Maccarrone M, D'Addario C^§. Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells. Brain Behav Immun. 2015 Mar;45:139-44. ^§ corresponding authors

 

Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P. Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015 Oct 1;155:68-75.

 

Cifani C, Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Di Francesco A, Maccarrone M, D'Addario C^§. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? Front Neurosci. 2015 Jun 8;9:187. ^§ corresponding authors

 

Mancino S, Burokas A, Gutiérrez-Cuesta J, Gutiérrez-Martos M, Martín-García E, Pucci M, Falconi A, D'Addario C, Maccarrone M, Maldonado R. Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior. Neuropsychopharmacology. 2015 May 6. doi: 10.1038/npp.2015.129.

 

Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D'Addario C^§. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addict Biol. 2016, 21(6):1168-1185. ^§ corresponding authors

 

Caputi FF, Palmisano M, D'Addario C, Candeletti S, Romualdi P.Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. Drug Alcohol Depend. 2015; 155: 68-75.

 

Pucci M, D'Addario C^§. Assessing Gene Expression of the Endocannabinoid System. Methods Mol Biol. 2016;1412:237-46. ^§ corresponding authors

 

Ferri E, Arosio B, D'Addario C, Galimberti D, Gussago C, Pucci M, Casati M, Fenoglio C, Abbate C, Rossi PD, Scarpini E, Maccarrone M, Mari D. Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. J Neurol Sci. 2016 Mar 15;362:283-6.

 

Catanzaro G, Pucci M, Viscomi MT, Lanuti M, Feole M, Angeletti S, Grasselli G, Mandolesi G, Bari M, Centonze D, D'Addario C^§, Maccarrone M. Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis. J Neuroimmunol. 2016 May 15;294:32-40. ^§ corresponding authors

 

Zoratto F, Romano E, Pascale E, Pucci M, Falconi A, Dell'Osso B, Maccarrone M, Laviola G, D'Addario C, Adriani W. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. Neuroscience. 2017 Jan 6;340:101-116.

 

D'Addario C^§, Shchetynsky K, Pucci M, Cifani C, Gunnar A, Vukojević V, Padyukov L, Terenius L. Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Mar 21;76:195-203. ^§ corresponding author

 

Adriani W, Romano E, Pucci M, Pascale E, Cerniglia L, Cimino S, Tambelli R, Curatolo P, Granstrem O, Maccarrone M, Laviola G, D'Addario C. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. Eur Child Adolesc Psychiatry. 2018 Feb;27(2):241-252.

 

D'Addario C^§, Micale V, Di Bartolomeo M, Stark T, Pucci M, Sulcova A, Palazzo M, Babinska Z, Cremaschi L, Drago F, Carlo Altamura A, Maccarrone M, Dell'Osso B. A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia. Schizophr Res. 2017 Jan 17. pii: S0920-9964(17)30031-2. ^§ corresponding author

 

D'Addario C^§, Candia SB, Arosio B, Di Bartolomeo M, Abbate C, Casè A, Candeletti S, Romualdi P, Damanti S, Maccarrone M, Bergamaschini L, Mari D. Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer's disease, a case report. J Neurol Sci. 2017 Jan 15;372:211-216. doi: 10.1016/j.jns.2016.11.052. ^§ corresponding author

 

Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, D'Addario C^§, Pautassi RM. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. ^§ corresponding author

 

D'Addario C^§, Palazzo MC, Benatti B, Grancini B, Pucci M, Di Francesco A, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Altamura AC, Maccarrone M, Dell'Osso B. Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:314-321. ^§ corresponding author

 

Cimino S, Cerniglia L, Ballarotto G, Marzilli E, Pascale E, D'Addario C, Adriani W, Tambelli R. DNA Methylation at the DAT Promoter and Risk for Psychopathology: Intergenerational Transmission between School-Age Youths and Their Parents in a Community Sample. Front Psychiatry. 2018 Jan 10;8:303.

 

Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia. Neuropharmacology. 2019 Mar 1;146:212-221.

 

Pucci M, Micioni Di Bonaventura MV, Wille-Bille A, Fernández MS, Maccarrone M, Pautassi RM, Cifani C, D'Addario C^§. Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. Neurosci Biobehav Rev. 2018 Jul 11. pii: S0149-7634(18)30108-8.

 

Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, Miranda-Morales RS, Pucci M, Bellia F, D'Addario C^§, Pautassi RM.  Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88.

 

Pucci M, Micioni Di Bonaventura MV, Zaplatic E, Bellia F, Maccarrone M, Cifani C, D'Addario C^§. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. Int J Eat Disord. 2018 Dec 22. doi: 10.1002/eat.22989.

 

Wille-Bille A, Bellia F, Jiménez García AM, Miranda-Morales RS, D'Addario C^§, Pautassi RM. Early exposure to environmental enrichment modulates the effects of prenatal ethanol exposure upon opioid gene expression and adolescent ethanol intake. Neuropharmacology. 2020 Mar 15;165:107917.

 

Fernández MS, Bellia F, Ferreyra A, Chiner F, Jiménez García AM, D'Addario C^§, Pautassi RM. Short-term selection for high and low ethanol intake during adolescence exerts lingering effects in stress-induced ethanol drinking and yields an anxiety-prone phenotype. Behav Brain Res. 2020 Feb 17;380:112445.

 

Ginés I, Gil-Cardoso K, D'Addario C, Falconi A, Bellia F, Blay MT, Terra X, Ardévol A, Pinent M, Beltrán-Debón R. Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats. Biomolecules. 2019 Dec 12;9(12). pii: E865

 

Falconi A, Bonito-Oliva A, Di Bartolomeo M, Massimini M, Fattapposta F, Locuratolo N, Dainese E, Pascale E, Fisone G, D'Addario C^§. On the Role of Adenosine A2A Receptor Gene Transcriptional Regulation in Parkinson's Disease. Front Neurosci. 2019 Jul 10;13:683

 

Cimino S, Cerniglia L, Ballarotto G, Marzilli E, Pascale E, D'Addario C, Adriani W, Maremmani AGI, Tambelli R. Children's DAT1 Polymorphism Moderates the Relationship Between Parents' Psychological Profiles, Children's DAT Methylation, and Their Emotional/Behavioral Functioning in a Normative Sample. Int J Environ Res Public Health. 2019 Jul 18;16(14). pii: E2567.

 

Dufrusine B, Di Francesco A, Oddi S, Scipioni L, Angelucci CB, D'Addario C, Serafini M, Häfner AK, Steinhilber D, Maccarrone M, Dainese E. Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation. Front Immunol. 2019 Jun 28;10:1347. doi: 10.3389/fimmu.2019.01347. eCollection 2019.

 

Pucci M, Micioni Di Bonaventura MV, Vezzoli V, Zaplatic E, Massimini M, Mai S, Sartorio A, Scacchi M, Persani L, Maccarrone M, Cifani C, D'Addario C^§. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Front Genet. 2019 Jun 14;10:523.

 

Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C^§, Cifani C. Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. J Psychopharmacol. 2019 Dec;33(12):1550-1561.

 

D'Addario C^§, Bellia F, Benatti B, Grancini B, Vismara M, Pucci M, De Carlo V,  Viganò C, Galimberti D, Fenoglio C, Scarpini E, Maccarrone M, Dell'Osso B. Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder. J Psychiatr Res. 2019 Jul;114:17-23.

 

Nassan M, Veldic M, Winham S, Frye MA, Larrabee B, Colby C, Biernacka J, Bellia F, Pucci M, Terenius L, Vukojevic V, D'Addario C^§. Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder. J Affect Disord. 2020 Apr 15;267:96-102.

 

Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C, Dell'Osso B, Pariante CM, Perretti M, D'Acquisto F. Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Brain Behav Immun. 2020 Feb 29:S0889-1591(19)31560-0.

 

D'Addario C^§, Zaplatic E, Giunti E, Pucci M, Micioni Di Bonaventura MV, Scherma M, Dainese E, Maccarrone M, Nilsson IA, Cifani C, Fadda P. Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa. Int J Eat Disord. 2020 Apr 10. doi: 10.1002/eat.23271.

 

Vismara M, Cirnigliaro G, Piccoli E, Giorgetti F, Molteni L, Cremaschi L, Fumagalli GG, D'addario C, Dell'Osso B. Crossing Borders Between Frontotemporal Dementia and Psychiatric Disorders: An Updated Overview. J Alzheimers Dis. 2020 Apr 16. doi: 10.3233/JAD-191333.

 

Lambacher G, Pascale E, Pucci M, Mangiapelo S, D'Addario C, Adriani W. Search for an epigenetic biomarker in ADHD diagnosis, based on the DAT1 gene 5'-UTR methylation: a new possible approach. Psychiatry Res. 2020;291:113154.

 

Tonelli E, Pascale E, Troianiello M, D'Addario C, Adriani W. DAT1 Gene Methylation as an Epigenetic Biomarker in Attention Deficit Hyperactivity Disorder: A Commentary. Front Genet. 2020;11:444. doi: 10.3389/fgene.2020.00444.

 

Bellia F, Fernández MS, Fabio MC, Pucci M, Pautassi RM, D'Addario C^§. Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence. Drug Alcohol Depend. 2020;212:108025.

 

Sabatucci A, Berchet V, Bellia F, Maccarrone M, Dainese E, D'Addario C^§, Pucci M. A new methodological approach for in vitro determination of the role of DNA methylation on transcription factor binding using AlphaScreen® analysis: Focus on CREB1 binding at hBDNF promoter IV. J Neurosci Methods. 2020;341:108720.

 

Rubino A, D'Addario C, Di Bartolomeo M, Michele Salamone E, Locuratolo N, Fattapposta F, Vanacore N, Pascale E. DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients. Acta Neurol Scand. 2020. doi: 10.1111/ane.13279.

 

Stark T, Di Bartolomeo M, Di Marco R, Drazanova E, Platania CBM, Iannotti FA, Ruda-Kucerova J, D'Addario C, Kratka L, Pekarik V, Piscitelli F, Babinska Z, Fedotova J, Giurdanella G, Salomone S, Sulcova A, Bucolo C, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, Micale V. Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. Biochem Pharmacol. 2020;177:114004.

 

^§ corresponding author

 

 

 

Capitoli Libri

 

Pucci, M., D'Addario, C. Assessing Gene Expression of the Endocannabinoid System. Methods Mol Biol. (2016) 1412:237-46.

 

D’Addario, C., Maccarrone, M., Alcohol and epigenetic modulations. Molecular Aspects of Alcohol and Nutrition. A Volume in the Molecular Nutrition Series (2016) Chapter 21. ISBN: 978-0-12-800773-0

 

D’Addario, C L’epigenetica. I radicali liberi e la loro rilevanza in biomedicine (2016). Appendice B

 

D’Addario C, Pucci M. Basi di epigenetica: focus sullo studio della metilazione del DNA gene-specifica. Metodologie Biochimiche e Biomolecolari. Zanichelli, 2019.

 

Elenco partecipazione a Congressi nazionali ed internazionali ultimi 10 anni

 

1. Claudio D’Addario Epigenetic regulation in alcoholism: preclinical and clinical evidence. 7th MNS Conference 23-27 June 2019, Marrakech, Morocco. INVITED SPEAKER
2. Claudio D’Addario Epigenetic regulation of BDNF in Bipolar Disorder: link between gene and environment. 7th MNS Conference 23-27 June 2019, Marrakech, Morocco. INVITED SPEAKER
3. Claudio D’Addario Transcriptional Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes  in Obesity: preclinical and clinical evidence. 60° Congresso della Società Italiana di Biochimica e Biologia Molecolare (SIB), 18-20 Settembre 2019, Lecce, Italy. INVITED SPEAKER
4. Claudio D'Addario, Fabio Bellia, AranzaWille-Bille, Klementy Shchetynsky, Mariangela Pucci, Leonid Padyukov, Ricardo Marcos Pautassi, Lars Terenius. Transcriptional regulation of prodynorphin gene in alcohol dependence: preclinical and clinical evidence. 39° Congresso nazionale SIF, 20-23 Novembre 2019, Firenze, Italy. INVITED SPEAKER
5. Bellia F, Wille-Bille A, Pucci M, Miranda-Morales RS, Pautassi RM, D’Addario C. Alcohol consumption during pregnancy induces altered transcriptional regulation in mothers and offspring partially counteracted by environment enrichment. 39th National Congress of the SIF. November 20.23, 2019 – Firenze, Italy
6. Bellia F, Wille-Bille A, Pucci M, Miranda-Morales RS, Pautassi RM, D’Addario C.

Alcohol consumption during pregnancy induces altered transcriptional regulation in mothers and offspring partially counteracted by environment enrichment. 17th ESBRA – European Society for Biomedical Research on Alcoholism. September 21-24, 2019 – Lille, France.

1. Bellia F, Benatti B, Grancini B, Vismara M, Pucci M, De Carlo V, Galimberti D, Fenoglio C, Scarpini E, Maccarrone M, Dell’Osso B, D’Addario C.

On the role of DNA methylation and hydroxymethylation in Obsessive Compulsive Disorder: focus on BDNF.32nd ECNP Congress. September 7-10, 2019 – Copenaghen, Denmark.

1. Bellia F, Wille-Bille A, Pucci M, Miranda-Morales RS, Pautassi RM, D’Addario C.
2. Alcohol consumption during pregnancy induces altered transcriptional regulation in mothers and offspring partially counteracted by environment enrichment. 50th International Narcotics Research Conference, July 7-11, 2019 – New York, NY, USA
3. Bellia F, Benatti B, Grancini B, De Carlo V, Vismara M, Galimberti D, Pucci M, Maccarrone M, Dell’Osso B, D’Addario C. DNA methylation and hydroxymethylation in OCD: preliminary findings. 7th Medittanean Neuroscience conference. June 23-27, 2019 – Marrakech, Morocco.
4. Bellia F, Wille-Bille A, Pucci M, Miranda-Morales RS, Maccarrone M, Pautassi RM, D’Addario C.
5. Prenatal alcohol exposure and postpartum alcohol use patterns: preliminary data on the effects of environmental enrichment on transcriptional regulation of relevant key genes. 1st International Conference “Perinatal Origins of Neuropsychiatric Disorders: from molecular mechanisms to therapeutic perspectives. May 29-31, 2019 – Palermo, Italy
6. Bellia F, Dell’Osso B, Vismara M, Galimberti D, Pucci M, Maccarrone M, Vukojević V, Terenius L, D’Addario C. Epigenetic regulation of Oxytocin receptor: parallel alterations in Alcoholism and Obsessive Compulsive Disorder.Annual Meeting of Cellular and Molecular Biotechnologies Doctoral Programmes. February 15, 2019 - Teramo, Italy
7. Martina Di Bartolomeo, Tibor Stark, Mariangela Pucci, Filippo Drago, Martin Kuchar, Mauro Maccarrone, Vincenzo Micale, Claudio D'Addario. Selective regulation of cb1 and d2 receptor genes transcription by prenatal delta-9-tetrahydrocannabinol exposure. ECNP Workshop, 7-10 Marzo 2019, Nizza, Francia
8. Claudio D’Addario, Mariangela Pucci, Aranza Willie-Billie, Vladana Vukojević, Leonid Padyukov, Carlo Cifani, Ricardo Pautassi, Lars Terenius. On the role of dynorphin gene in alcoholism: preclinical and clinical evidence. 39th IMAG Conference The International Meeting on Alcohol and Global Health, 24th and 25th September 2018 in Leuven, Belgium
9. Claudio D’Addario Ruolo dei meccanismi epigenetici nei disturbi psichiatrici. XIII Convegno Nazionale SINDEM Firenze, 19-21 aprile 2018. INVITED SPEAKER
10. Claudio D’Addario Regolazione epigenetica del Sistema degli Endocannabinoidi nelle Psicosi Maggiori, XXII CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA

DI PSICOPATOLOGIA, 21-24/02/2018, Roma, Italy. INVITED SPEAKER

1. F. Bellia, B. Benatti, B. Grancini, V. De Carlo, M. Vismara, D. Galimberti, M. Maccarrone, B. Dell'Osso, C. D'Addario. Transcriptional regulation of BDNF and Oxytocin receptor genes in Obsessive Compulsive Disorder. 31st ECNP Congress. October 6-9, 2018 - Barcelona, Spain.
2. Martina Di Bartolomeo, Tibor Stark, Mariangela Pucci, Filippo Drago, Martin Kuchar, Mauro Maccarrone, Vincenzo Micale, Claudio D'Addario. Effects of perinatal cannabis exposure on transcriptional regulation of dopamine receptor d2 and cannabinoid receptor 1 in rats at adulthood.  31st ECNP Congress, 6-9 Ottobre 2018, Barcellona Spagna
3. Bellia F, Dell’Osso B, Vismara M, Galimberti D, Maccarrone M, Vukojević V, Terenius L, D’Addario C. Epigenetic regulation of oxytocin receptor: possible marker of the early stages of Alcoholism onset?. XXI SIF Seminar. September 19-22, 2018 – Bresso (MI), Italy
4. F.Bellia, B. Benatti, V. De Carlo, M. Vismara, M. Maccarrone, B. Dell'Osso, C. D'Addario. Exploring epigenetic mechanisms in OCD. 11th FENS Forum of Neuroscience. July 7-11, 2018 - Berlin, Germany.
5. F. Bellia, A. Sabatucci, M. Pucci, C. D’Addario. Development of an innovative assay to analyze the influence of DNA methylation at BDNF gene promoter on CREB binding. Annual Meeting of Cellular and Molecular Biotechnologies Doctoral Programmes. February 23, 2018 - L'Aquila, Italy
6. Claudio D’Addario, Klementy Shchetynsky, Mariangela Pucci, Carlo Cifani, Agneta Gunnar, Vladana Vukojević, Leonid Padyukov, Lars Terenius. DNA methylation patterns at prodynorphin gene promoter in alcoholism. Alcoholism and Stress: A Framework for Future Treatment Strategies May 9 - 12, 2017. Volterra, Italy.
7. M. Di Bartolomeo, V. Micale, T. Stark, M. Pucci , A. Sulcova, M. Palazzo, Z. Babinska, L. Cremaschi , F. Drago, A.C. Altamura, M. Maccarrone, B. Dell’Osso, C. D'Addario.  Schizophrenia and Cannabinoid receptor type1 gene regulation: a preclinical and clinical study. 6 th Conference 2017 Mediterranean Neuroscience Society, Malta 12-25/06/2017.
8. Claudio D’Addario. Epigenetic regulation of CnR1 gene in schizophrenia. 38° Congresso nazionale SIF, Rimini 25-28 Ottobre 2017. INVITED SPEAKER
9. Giusepponi  M.E., Kern M., Micioni Di Bonaventura M.V., Polidori C., D’Addario C., Schon M., Dietrich A., Bluher M., Kloting N., Cifani C. Olfactory receptor 984 a new target for obesity in rats and humans? 38° Congresso nazionale SIF, Rimini 25-28 Ottobre 2017.
10. Claudio D’Addario. Interplay between epigenetic regulation of BDNF and Prodynorphin genes in Bipolar Disorder. 19th Annual Conference of the International Society for Bipolar Disorders, Washington DC (USA) 4-7 May 2017. INVITED SPEAKER
11. D’Addario Claudio, Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Valeria Vezzoli, Massimo Scacchi, Luca Persani, Mauro Maccarrone, Carlo Cifani. Synergistic interactions between opioid and cannabinoid systems in obesity. 6th Conference of the Mediterranean Neuroscience Society (MNS). Malta, June 12 – 15, 2017. INVITED SPEAKER
12. Claudio D’Addario. EATING DISORDERS AND ALCOHOL ABUSE: GENES AND GENDER. Workshop ADDICTION: A NEUROBIOLOGICAL AND COGNITIVE BRAIN DISORDER March 28 - 29, 2017 Strasbourg (France) INVITED SPEAKER
13. Di Bartolomeo M., Stark T., Pucci M., Ruda-Kucerova J., Pekarik V., Drago F., Sulcova A., Mechoulam R., Maccarrone M., Altamura A.C., Micale V., Dell’Osso B., D’Addario C. Preclinical  and  clinical  evidence  of  selective  cannabinoid   receptor type 1 gene regulation in schizofrenia. XIX CONGRESSO NAZIONALE  SINPF Il farmaco e le neuroscienze Acireale (CT), 11-14 ottobre 2016.
14. Pucci M., Micioni Di Bonaventura M.V., Vezzoli V., Scacchi M., Persani L., Mai S., Maccarrone M., Cifani C., D’Addario C. Regolazione epigenetica sesso dipendente di CNR1 nell’obesità. XIX CONGRESSO NAZIONALE  SINPF Il farmaco e le neuroscienze Acireale (CT), 11-14 ottobre 2016. AWARD BEST POSTER
15. M. Di Bartolomeo, T. Stark, B. Dell’Osso, M. Pucci, J. Ruda-Kucerova, V. Pekarik, F. Drago, A. Sulcova, R. Mechoulam, A.C. Altamura, M. Maccarrone, V. Micale, C. D’Addario. 29 th ECNP (European College Of Neuropsychopharmacology) Congress, Vienna, Austria. 17-20/09/16.
16. Benatti  B.,  Dell’Osso  B.,  D’Addario  C.,  Palazzo  M.C.,  Pucci  M.,   Falconi  A.,  Camuri  G.,  Galimberti  D.,  Scarpini  E.,  Maccarrone  M.,  Altamura A.C Trascrizione  del  gene  della  prodinorfina  nel  Disturbo  Bipolare:  interazione  con  la  regolazione  epigenetica  del  Brain  Derived Neurotrophic Factor. XIX CONGRESSO NAZIONALE  SINPF Il farmaco e le neuroscienze Acireale (CT), 11-14 ottobre 2016.
17. C. D’Addario, M. Pucci, M.V. Micioni Di Bonaventura, M. Maccarrone, C. Cifani- ENDOGENOUS OPIOID SYSTEM GENES REGULATION EXPRESSION IN OBESITY. International Narcotics Research Conference (INRC) 2016 10 - 14 July 2016, Bath (UK).
18. C. Cifani, M.V. Micioni Di Bonaventura, M. Pucci, M.E. Giusepponi, C. Lambertucci, R. Volpini, M. Maccarrone, C. D'Addario. EPIGENETIC REGULATION OF ADENOSINE A2A RECEPTOR GENE TRANSCRIPTION ON COMPULSIVE FOOD CONSUMPTION. 10th FENS Forum of Neuroscience. July 2-6, 2016, Copenhagen, Denmark.
19. M.V. Micioni Di Bonaventura, T. Lutz, A. Romano, C. D'Addario, L. Asarian, C. Cifani. ESTRADIOL-DEPENDENT DECREASES IN EMOTIONAL BINGE-LIKE EATING ARE ASSOCIATED WITH DECREASED BRAIN PERK EXPRESSION IN OVARIECTOMIZED RATS. 10th FENS Forum of Neuroscience. July 2-6, 2016, Copenhagen, Denmark.
20. Francesca Zoratto, Emilia Romano, Esterina Pascale, Mauro Maccarrone, Walter Adriani, Claudio D’Addario, Giovanni Laviola. Experience of stakes in a rat gambling task induces selective gene down-regulation in serotonin and dopamine systems: a possible role for epigenetic mechanism in gambling proneness? European Brain and Behavior Society meeting, 12-15 September 2015, Verona, Italy.
21. Pucci M., Micioni Di Bonaventura M.V., Vezzoli V., Scacchi M., Persani L., Mai S., Di Francesco A., Maccarrone M., Cifani C.,·D'Addario C. P.1.a.021 Genetic and epigenetic regulation of cannabinoid receptor type-1 in obesity. 28th ECNP Congress, 29 August-1 September 2015, Amsterdam, The Netherlands.
22. A. Falconi, B. Dell'Osso, A. Di Francesco, M.C. Palazzo, B. Benatti, B. Galimberti, A.C. Altamura, M. Maccarrone, C. D'Addario. Catechol-O-methyltransferase gene expression regulation in Major Depressive Disorder and Bipolar disorder. ECNP Workshop for Junior Scientist in Europe il 12-15 March 2015 a Nice, France.
23. Claudio D'Addario. Transcriptional Regulation of Endocannabinoid System Genes in Mental Disorders.  Cannabinoid Function in the CNS Gordon Research Conference “From Molecules to Disease Mechanisms”. May 24 - 29, 2015. Lucca (Barga), IT INVITED SPEAKER
24. Claudio D’Addario, Vladana Vukojevic, Agneta Gunnar, Klementy Shchetynsky, Leonid Padyukov, Mauro Maccarrone, Lars Terenius. Genetic association between variations in prodynorpin gene and alcoholism points up epigenetic regulation of gene activity. 5th Conference of the Mediterranean Neuroscience Society (MNS). Pula (CA), Sardinia, Italy, 12-15 June 2015. INVITED SPEAKER
25. C D’Addario, MV Micioni Di Bonaventura, M Pucci, ME Giusepponi, A Di Francesco, M Maccarrone, C Cifani. EPIGENETIC REGULATION OF HYPOTHALAMIC NEUROPEPTIDES GENE EXPRESSION IN DIET INDUCED OBESITY RESISTANT RATS. The 2015 Obesity Summit, 14-16 April 2015, London, UK.
26. Claudio D'ADDARIO, Bernardo DELL'OSSO, Mariacarlotta PALAZZO, Mariangela PUCCI, Anastasia FALCONI, Mariavittoria DI BONAVENTURA, Carlo CIFANI, Carlo A. ALTAMURA, Mauro MACCARRONE. Transcriptional regulation of endocannabinoid system genes in psychiatric disorders. Society for Neuroscience meeting, October 17-21, Chicago, USA.
27. A. Falconi, B. Dell'Osso, A. Di Francesco, M.C. Palazzo, B. Benatti, B. Galimberti, A.C. Altamura, M. Maccarrone, E. Dainese, C. D'Addario. Affective disorders and epigenetics: study of possible mechanisms and biological targets. 27th ECNP Congress, 18-21 October 2014 Berlin, Germany.
28. M.C. Palazzo, B. Dell'Osso, B. Benatti, G. Camuri, C. D'Addario, D. Galimberti, C. Fenoglio, E. Scarpini, A. Di Francesco, M. Maccarrone, A.C. Altamura. Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. 27th ECNP Congress, 18-21 October 2014 Berlin, Germany.
29. Mauro Maccarrone, Andrea Di Francesco, Bernardo Dell ́Osso, Daniela Galimberti, A. Carlo Altamura and Claudio D’Addario. EPIGENETIC REGULATION OF THE ENDOCANNABINOID SYSTEM IN HUMAN PSYCHIATRIC DISORDERS. 24th ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY BAVENO ITALY. June 28 – July 3, 2014.
30. Micioni Di Bonaventura M.V., Cifani C., Pucci M., Lambertucci C., Volpini R., Maccarrone M., D'Addario C. P.1.024 Epigenetic regulation of A2A gene transcription in a model of binge eating in the amygdala complex of female rats. 27th ECNP Congress, 18-21 October 2014, Berlin, Germany.
31. Micioni Di Bonaventura M. V., Pucci M., Giusepponi M.E., Lambertucci C., Volpini R., Maccarrone M., D'Addario C.,Cifani C. P.1.a.028 Epigenetic regulation of adenosine A2A and dopamine D2 receptor gene transcription on compulsive food consumption. 27th ECNP Congress, 18-21 October 2014, Berlin, Germany.·
32. Tijana Jovanović-Talisman, Steven J. Tobin, Eliedonna E. Cacao, Daniel Wing Wo Hong, Claudio D’Addario, Lars Terenius, Vladana Vukojević. Cellular and molecular mechanisms of ethanol action at the nanoscopic level. Alcoholism and Stress: A Framework for Future Treatment Strategies Volterra, Italy May 6 – 9, 2014.
33. Claudio D´Addario, Vladana Vukojević, Mirko Tantimonaco, Agneta Gunnar, Mauro Maccarrone, Lars Terenius. New strategies to study endogenous opioid system regulation in alcoholism: evaluation of ethanol mechanisms by molecular imaging, genetic and epigenetic analysis.  Alcoholism and Stress: A Framework for Future Treatment Strategies Volterra, Italy May 6 – 9, 2014.
34. C. Cifani, M. V. Micioni Di Bonaventura, M. Pucci, M. E. Giusepponi, C. Lambertucci, R. Volpini, A. Romano, S. Gaetani, M. Massi, M. Maccarrone, C. D’Addario. EPIGENETIC REGULATION OF A2A GENE TRANSCRIPTION IN A MODEL OF BINGE EATING IN THE AMYGDALA COMPLEX OF FEMALE RATS. XVIII CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI NEUROPSICOFARMACOLOGIA, Torino, 3-6 Giugno 2014.
35. D´Addario C, Dell´Osso B, Di Francesco A, Falconi A, Maccarrone M, Altamura AC. Affective disorders and epigenetics: searching for novel biomarkers and treatment targets. XVIII CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI NEUROPSICOFARMACOLOGIA, Torino, 3-6 Giugno 2014.
36. S. Mancino, A. Burokas, J. Gutiérrez-Cuesta, M. Gutiérrez-Martos, E. Martín-García, M. Pucci , C. D’Addario, M. Maccarrone and R. Maldonado. BEHAVIOURAL MODEL OF FOOD ADDICTION IN MICE. The 2014 Obesity Summit, 1-3 April 2014, London, UK.
37. D´Addario C, Dell´Osso B, Di Francesco A, Falconi A, Maccarrone M, Altamura AC. Disturbi affettivi ed epigenetica: alla ricerca di nuovi biomarcatori e bersagli terapeutici. 18° CONGRESSO della Società Italiana di Psicopatologia, Torino, 12-15 febbraio 2014.
38. Pucci M., Micioni Di Bonaventura M.V., Ciccocioppo R., Maccarrone M., Cifani C., D'Addario C. P.1.a.026 Different regulation of endogenous neuropeptides gene expression in resistance to diet-induced obesity. 26th ECNP Congress, 5-9 October 2013, Barcelona, Spain.
39. Di Francesco A., Arosio B., Gussago C., Dainese E., Mari D., D'Addario C., Maccarrone M. Aletred DNA methylation at faah and alox5 genes as a basis for the dysregulated endocannabinoid-eicosanoid network in Alzheimer’s Disease. 36° Congresso Nazionale della Società Italiana di Farmacologia. Torino, 23-26 ottobre 2013
40. M.V. Micioni Di Bonaventura, M. Pucci, M. Maccarrone, V. Cuomo, R. Ciccocioppo, S. Gaetani, C. Cifani, C. D’Addario. Resistance to diet-induced obesity is associated to selective epigenetic regulation of hypothalamic neuropeptides gene expression. 36° Congresso Nazionale della Società Italiana di Farmacologia. Torino, 23-26 ottobre 2013
41. M. Pucci, M.V. Micioni Di Bonaventura, M. Maccarrone, V. Cuomo, R. Ciccocioppo, S. Gaetani, C. D’Addario, C. Cifani. Regulation of nociceptin/orphanin FQ system gene expression in binge eating episodes. 36° Congresso Nazionale della Società Italiana di Farmacologia. Torino, 23-26 ottobre 2013
42. E Dainese, A Di Francesco, C D'Addario, S Oddi, M Maccarrone Iron activates 5-lipoxygenase and induces its nuclear translocation: implications for the pathogenesis of Alzheimer. Federation of European Biochemical Societies CONGRESS 2013 “Mechanisms in Biology”. July 6th - 11th 2013, St. Petersburg. Published on FEBS JOURNAL Volume 280 Pagine 431-431.
43. Di Francesco A, Dell’Osso B, Falconi A, Palazzo MC, Benatti B, Galimberti D, Arosio B, Altamura AC, Maccarrone M, D’Addario C. Possible interplay between BDNF and Dhynorphin in bipolar disorder: role of epigenetic mechanism. 26th ECNP Congress a Barcellona 5-9 Ottobre 2013.
44. B Dell'Osso, C D'Addario, C Altamura. Differences between major depressive disorder and bipolar disorder in selective methylation of brain derived neurotrophic factor (BDNF) gene promoter. 10 th International Conference on Bipolar Disorders, June 13-16, 2013. Miami Beach, Florida, USA. Published on BIPOLAR DISORDERS Volume 15 Pagine 70-71. AWARD BEST POSTER
45. A Di Francesco, B Dell'Osso, MC Palazzo, B Benatti, D Galimberti, B Arosio, AC Altamura, M Maccarrone, C D'Addario. Increased DNA methylation of the prodynorphin gene promoter in peripheral blood mononuclear cells from patients with bipolar disorder. 26th ECNP Congress 2013, Barcelona, Spain. Published on European Neuropsychopharmacology Volume 23 Numero Supplement 2 Pagine S163-S164; Elsevier. AWARD BEST POSTER
46. M Pucci, MV Micioni Di Bonaventura, R Ciccocioppo, M Maccarrone, C Cifani, C D'Addario. Different regulation of endogenous neuropeptides gene expression in resistance to diet-induced obesity. European Opioid Conference, 10th - 12th April 2013, Guildford, UK. Published on European Neuropsychopharmacology Volume 23 Numero Supplement 2. Elsevier. AWARD BEST POSTER
47. C. D’Addario, A. Di Francesco, B. Arosio, C. Gussago, B. Dell’Osso, M. Barie, D. Galimberti, E. Scarpini, C.A. Altamura, D. Mari and M. Maccarrone. Epigenetic mechanisms inAlzheimer Disease. Role of fatty acid amide hidrolase in late-onset AD subjects and in a rare ase of monozygotic twins discordant for AD. First joint Spanish-Italian meeting on cannabinoid research. XIII REUNIÓN ANUAL SEIC, Madrid, November 29th- December 1st 2012.
48. C. D’Addario, A. Di Francesco, B. Arosio, C. Gussago, B. Dell’Osso, M. Barie, D. Galimberti, E. Scarpini, C.A. Altamura, D. Mari and M. Maccarrone . Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease. Convegno Monotematico “Cannabinoidi: presente e futuro” Ferrara 14 Settembre/15 Settembre 2012 INVITED SPEAKER
49. B Dell’Osso, C D’Addario, M Palazzo, B Benatti, L Lietti, E Cattaneo, D Galimberti, C Fenoglio, F Cortini, C Dobrea, E Scarpini, B Arosio, M Di Benedetto, P Romualdi, S Candeletti, D Mari, M Mari, M Maccarrone, AC Altamura Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients vs controls and potential influence of pharmacological treatments. 20th European Congress of Psychiatry, Prague, Czech Republic, from 3-6 March, 2012. Published on European Psychiatry Volume 27 pagine 1.
50. C D'Addario, B Dell'Osso, A Di Francesco, MC Palazzo, B Benatti, D Galimberti, B Arosio, AC Altamura, M Maccarrone. DNA methylation is selectively altered in bipolar disorder and linked to DNA methyltransferases and histone deacetylases mRNAs levels. 25th ECNP Congress Vienna, Austria 13–17 October 2012. Published on European Neuropsychopharmacology. Volume 22 Pagine S285-S286. Elsevier. AWARD BEST POSTER
51. C D'Addario, B Arosio, A Di Francesco, C Abbate, A Case, L Bergamaschini, D Mari, M Maccarrone. Epigenetic mechanisms in a rare case of monozygotic twins discordant for Alzheimer's disease. 16th Congress of the EFNS, Stockholm, Sweden, September 2012. Published on EUROPEAN JOURNAL OF NEUROLOGY Volume 19 Pagine 474-474 Editore WILEY-BLACKWELL.
52. B Benatti, B Dell'Osso, C D'Addario, L Lietti, D Galimberti, E Scarpini, MC Palazzo, F Cortini, M Maccarrone, AC Altamura Selective methylation of brain derived neurotrophic factor gene promoter in bipolar disorder: differences between patients and controls. ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe Nice, France 15–18 March 2012. Published on European Neuropsychopharmacology Volume 22 Pagine S16; Elsevier
53. B Dell'Osso, C D'Addario, B Benatti, E Cattaneo, L Lietti, D Galimberti, F Cortini, E Scarpini, P Romualdi, AC Altamura. Selective DNA methylation of brain derived neurotrophic factor promoter and nociceptin gene in bipolar disorder. 24 ECNP Congress Paris, France 3–7 September 2011. European Neuropsychopharmacology Volume 21 Pagine S434; Elsevier.
54. Claudio D’Addario, Francesca Felicia Caputi, Sanzio Candeletti, Sven Ove Ogren, Lars Terenius, Tomas Ekstrom, Mauro Maccarrone, Patrizia Romualdi. A role for epigenetic mechanisms in the regulation of prodynorphin expression by alcohol. European Opioid Conference, Krakow (Poland) April 13-15, 2011. Published on Pharmacological Reports, Volume 63, Numero 1, Pagine 208-209; Elsevier. INVITED SPEAKER
55. C D’Addario, M Palazzo, E Cattaneo, D Galimberti, E Scarpini, N Bresolin, B Arosio, L Bergamaschini, S Candeletti, P Romualdi, AC Altamura. Selective DNA methylation of BDNF promoter and nociceptin gene in bipolar disorder. 19th European Congress of Psychiatry, EPA 2011, Vienna, Austria, 12-15 March, 2011. Published on European Psychiatry Volume 26 Pagine 200; Elsevier Masson.

1. D’Addario C, Caputi FF, Candeletti S, Rimondini R, Romualdi P. Epigenetic insight for mechanisms of opioid gene regulation induced by alcohol. XVII Congresso Nazionale della Società Italiana di NeuroPsicoFarmacologia Cagliari, 22-25 settembre 2010, P79 page 110.
2. D’Addario C, Dell’Osso B, Cattaneo E, Palazzo M, Galimberti D, Fenoglio C, Scarpini E, Arosio B, Bergamaschini L, Candeletti S, Romualdi P, Altamura AC. DNA hypermethylation of BDNF promoter in patients with bipolar disorder type II XVII Congresso Nazionale della Società Italiana di NeuroPsicoFarmacologia Cagliari, 22-25 settembre 2010, P17 page 82 AWARD BEST POSTER
3. D’Addario C, Caputi FF, Candeletti S, Rimondini R, Romualdi P. Alcohol exposures induce selective alterations on endogenous opioid system genes regulation in rat amygdala: possible epigenetic mechanisms; 23^nd European College of Neuropsychopharmacology Congress, 28 Agosto - 1 Settembre 2010, Amsterdam 6.b.007: TRAVEL AWARD
4. D'Addario C, Dell'Osso B, Galimberti D, Scarpini E, Arosio B, Bergamaschini L, Fenoglio C, Candeletti S, Romualdi P, Altamura AC. Selective DNA methylation of BDNF promoter in bipolar disorder; 23^nd European College of Neuropsychopharmacology Congress, 28 Agosto - 1 Settembre 2010, Amsterdam2.f.002.
5. D’Addario C, Caputi FF, Candeletti S, Romualdi P Different Alcohol exposures induce selective alterations on the expression of the endogenous opioid system genes: possible epigenetic mechanisms; WorldPharma 2010 17-23 July, 2010, Copenaghen INVITED SPEAKER
6. Terenius L, Vukojevic V, Ming Y, Johansson B, D’Addario C, Rigler R. Ethanol/Naltrexone interactions at the opioid receptor. CLSM/FCS study in live cells, 72nd Meeting of the College on Problems of Drug Dependence, Fairmont Scottsdale, Arizona, June 12-17, 2010
7. D’Addario C, Caputi FF, Candeletti S, Rimondini R, Romualdi P. ALCOHOL EXPOSURES INDUCE SELECTIVE ALTERATIONS ON ENDOGENOUS OPIOID SYSTEM GENES REGULATION IN RAT AMYGDALA: POSSIBLE EPIGENETIC MECHANISMS. INRC 2010 Malmö, Sweden July 11-16, 2010N 29, pp 87.