Prof. PUCCI Mariangela
Prof. PUCCI Mariangela

Email: mpucci@unite.it

Telefono: -

Facoltà di appartenenza: BIOSCIENZE E TECNOLOGIE AGRO-ALIMENTARI E AMBIENTALI


 
 
 
 

Curriculum accademico

 

Curriculum english version

 

Assistant Professor of Molecular Biology (BIO/11),  

MS in Biological Science at the University of L'Aquila, Italy; Ph.D. degree in Reproductive Biotechnology, at the University of Teramo, Italy;

Post-doctoral Fellow at the Department of Biosciences and Nutrition, Karolinska Institute, Stockholm (SE);

 

Scientific interests:

  • neurobiology and molecular mechanisms underlying human eating disorders and obesity;
  • development of new model for human binge eating behaviors in the worm C. elegans;
  • bioactive lipids and the molecular mechanisms of G protein-coupled receptor signalling;

 

Pubblicazioni

 
  1. Sabatuccia A, Berchet V, Bellia F, Maccarrone M, Dainese E, D'Addario C, Pucci M. A new methodological approach for in vitro determination of the role of DNA methylation on Transcription Factor binding using AlphaScreen® analysis: focus on CREB1 binding at hBDNF promoter IV. Journal of Neuroscience Methods Accepted/ In press.
  2. D'Addario C, Zaplatic E, Giunti E, Pucci M, Micioni Di Bonaventura MV, Scherma M, Dainese E, Maccarrone M, Nilsson IA, Cifani C, Fadda P. Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa. Int J Eat Disord. 2020 Apr 10. doi: 10.1002/eat.23271. [Epub ahead of print]
  3. Nassan M, Veldic M, Winham S, Frye MA, Larrabee B, Colby C, Biernacka J, Bellia F, Pucci M, Terenius L, Vukojevic V, D Addario C. Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder. J Affect Disord. 2020 Feb 3;267: 96-102. doi: 10.1016/j.jad.2020.02.002
  4. Micioni Di Bonaventura MV, Pucci M*, Giusepponi ME, (...), D’Addario C, Cifani C Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. Journal of Psychopharmacology. 2019; 33(12). 1550-1561
  5. Pucci M, Micioni Di Bonaventura MV, Wille-Bille A, (...), Cifani C, D'Addario, C. Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulationPucci Neuroscience and Biobehavioral Reviews 2019; 106, 165-181
  6. D'Addario C, Bellia F, Benatti B, Grancini B, Vismara M, Pucci M, (…), Maccarrone M, Dell'Osso B. Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder. Journal of Psychiatric Research, 2019, 114, 17-23
  7. Pucci M, Micioni Di Bonaventura MV, Zaplatic E, Bellia F, Maccarrone M, Cifani C, D'Addario C. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. Int J Eat Disord. 2018 Dec 22. doi: 10.1002/eat.22989. [Epub ahead of print]
  8. Giusepponi ME, Kern M, Chakaroun R, Wohland T, Kovacs P, Dietrich A, Schön MR, Krohn K, Pucci M, Polidori C, Micioni Di Bonaventura MV, Stumvoll M, Blüher M, Cifani C, Klöting N. Gene expression profiling in adipose tissue of Sprague Dawley rats identifies olfactory receptor 984 as a potential obesity treatment target. Biochem Biophys Res Commun. 2018 Nov 2;505(3):801-806. doi: 10.1016/j.bbrc.2018.09.137.
  9. Pucci M, Micioni Di Bonaventura MV, Wille-Bille A, Fernández MS, Maccarrone M, Pautassi RM, Cifani C, D'Addario C. Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation. Neurosci Biobehav Rev. 2018 Jul 11. pii: S0149-7634(18)30108-8. doi: 10.1016/j.neubiorev.2018.07.004
  10. Wille-Bille, A., Miranda-Morales, R.S., Pucci, M., Bellia, F., D'Addario, C., Pautassi, R.M. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. (2018) Prog Neuropsychopharmacol Biol Psychiatry. 85:77-88.
  11. D'Addario, C., Palazzo, MC, Benatti, B., Grancini, B., Pucci, M., Di Francesco, A., Camuri, G., Galimberti, D., Fenoglio, C., Scarpini, E., Altamura, A.C., Maccarrone, M., Dell'Osso, B. Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor. (2018) Prog Neuropsychopharmacol Biol Psychiatry. 82:314-321.
  12. Adriani, W., Romano, E., Pucci, M., Pascale, E., Cerniglia, L., Cimino, S., Tambelli, R., Curatolo, P., Granstrem, O., Maccarrone, M., Laviola, G., D'Addario, C. Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. (2017) Eur Child Adolesc Psychiatry. 27(2):241-252.
  13. D'Addario, C., Shchetynsky, K., Pucci, M., Cifani, C., Gunnar, A., Vukojević, V., Padyukov, L., Terenius, L. Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. (2017) Prog Neuropsychopharmacol Biol Psychiatry. doi: 10.1016/j.pnpbp.2017.03.012.
  14. Micioni Di Bonaventura, M.V., Lutz, T.A., Romano, A., Pucci, M., Geary, N., Asarian, L., Cifani, C. Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats. (2017) Int J Eat Disord. doi: 10.1002/eat.22687
  15. D'Addario, C., Micale, V., Di Bartolomeo, M., Stark, T., Pucci, M., Sulcova, A., Palazzo, M., Babinska, Z., Cremaschi, L., Drago, F., Altamura, A., Maccarrone, M., Dell'Osso, B. A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia. (2017) Schizophr Res. doi: 10.1016/j.schres.2017.01.022.
  16. Zoratto, F., Romano, E., Pascale, E., Pucci, M., Falconi, A., Dell'Osso, B., Maccarrone, M., Laviola, G., D'Addario, C., Adriani, W. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. (2016) Neuroscience doi: 10.1016/j.neuroscience.2016.10.041.
  17. Pucci, M., D'Addario, C. Assessing Gene Expression of the Endocannabinoid System. (2016) Methods Mol Biol.1412:237-46. doi: 10.1007/978-1-4939-3539-0_24.
  18. Catanzaro, G., Pucci, M.*, Viscomi, M.T., Lanuti, M., Feole, M., Angeletti, S., Grasselli, G., Mandolesi, G., Bari, M., Centonze, D., D'Addario, C., Maccarrone, M. Epigenetic modifications of Dexras 1 along the nNos pathway in an animal model of multiple sclerosis. (2016) J Neuroimmunol. 2016 294:32-40. doi: 10.1016/j.jneuroim.2016.03.009.
  19. Ferri, E., Arosio, B., D'Addario, C., Galimberti, D., Gussago, C., Pucci, M., Casati, M., Fenoglio, C., Abbate, C., Dionigi Rossi, P., Scarpini, E., Maccarrone, M., Mari, D. Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease. (2016) Journal of the Neurological Sciences 362: 283–286.
  20. Pucci M., Micioni Di Bonaventura M.V., Giusepponi M.E., Romano A., Filaferro M., Maccarrone M., Ciccocioppo R., Cifani C., D'Addario C. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. (2015) Addict Biol. doi: 10.1111/adb.12303.
  21. Cifani C., Micioni Di Bonaventura M.V., Pucci M., Giusepponi M.E., Romano A., Di Francesco A., Maccarrone M., D'Addario C. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? (2015) Front Neurosci. 2015 8;9:187
  22. Mancino S., Burokas A., Gutiérrez-Cuesta J., Gutiérrez-Martos M., Martín-García E., Pucci M., Falconi A., D'Addario C., Maccarrone M., Maldonado R. Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior.(2015) Neuropsychopharmacology. 40(12):2788-800.
  23. D'Addario, C., Micioni Di Bonaventura, M.V., Pucci, M., Romano, A., Gaetani, S., Ciccocioppo, R., Cifani, C., Maccarrone, M. Endocannabinoid signaling and food addiction. (2014) Neurosci Biobehav Rev. 47:203-24.
  24. Pucci,, Rapino, C., Di Francesco, A., Dainese, E., D'Addario, C., Maccarrone, M. Epigenetic control of skin differentiation genes by phytocannabinoids. (2013) British Journal of Pharmacology 170 (3) , pp. 581-591
  25. D'Addario, C., Di Francesco, A., Pucci, M., Finazzi Agrò, A., MacCarrone, M. Epigenetic mechanisms and endocannabinoid signalling. (2013) FEBS Journal 280 (9) , pp. 1905-1917
  26. Grimaldi, P., Pucci, M.*, Di Siena, S., Di Giacomo, D., Pirazzi, V., Geremia, R., Maccarrone, M. The faah gene is the first direct target of estrogen in the testis: Role of histone demethylase LSD1. (2012) Cellular and Molecular Life Sciences 69 (24) , pp. 4177-4190
  27. Lewis, S.E.M., Rapino, C., Di Tommaso, M., Pucci, M., Battista, N., Paro, R., Simon, L., (...), Maccarrone, M. Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men. (2012) PLoS ONE 7 (10), art. no. e47704
  28. Pucci, M., Pasquariello, N., Battista, N., Di Tommaso, M., Rapino, C., Fezza, F., Zuccolo, M., (...), Maccarrone, M. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. (2012) Journal of Biological Chemistry 287 (19), pp. 15466-15478
  29. Gironi, M., Pasquariello, N., Franchi, S., Pucci, M., Martinelli-Boneschi, F., Solaro, C., Centonze, D., (...), Maccarrone, M. Comment on "Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis". (2012) Brain pathology 22 (1), pp. 79
  30. Pucci, M., Pirazzi, V., Pasquariello, N., Maccarrone, M. Endocannabinoid signaling and epidermal differentiation. (2011) European Journal of Dermatology 21, pp. 29-34
  31. Catanzaro, G., Battista, N., Rossi, G., Di Tommaso, M., Pucci, M., Pirazzi, V., Cecconi, S., Maccarrone, M. Effect of capacitation on the endocannabinoid system of mouse sperm. (2011) Molecular and Cellular Endocrinology 343 (1-2), pp. 88-92
  32. Bari, M., Tedesco, M., Battista, N., Pasquariello, N., Pucci, M., Gasperi, V., Scaldaferri, M.L., (...), Maccarrone, M. Characterization of the endocannabinoid system in mouse embryonic stem cells. (2011) Stem Cells and Development 20 (1), pp. 139-147
  33. Oddi, S., Fezza, F., Catanzaro, G., De Simone, C., Pucci, M., Piomelli, D., Finazzi-Agrò, A., Maccarrone, M. Pitfalls and solutions in assaying anandamide transport in cells. (2010) Journal of Lipid Research 51 (8), pp. 2435-2444

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Ultimo aggiornamento: 10-06-2019
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